Ontology explorer

Gene ontology

Change ontology: Version 2014-12-22

Term or Synonym: use AND (NOT) or OR

Definition: use AND (NOT) or OR

restrict to BRENDA links:

Localization

Enzyme

1 different search results found

Details for beta-catenin destruction complex

Gene ontology ID

GO:0030877

Definition

A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome

Comment

Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.

Synonyms

1. 23S APC complex
2. APC-Axin-1-beta-catenin complex
3. Axin-APC-beta-catenin-GSK3B complex
4. BDC
5. beta-catenin degradation complex

References

1. PMID 14600025

Legend

is an element of the parent element

is a part of the parent element

is related to the parent element

derives from the parent element

/

/

at least 1 tissue/ enzyme/ localization link in this branch

/

/

tissue/ enzyme/ localization link to BRENDA

Condensed Tree View

Gene ontology

cellular_component is a

is a

cellular anatomical entity is a

is a

is a

425 BRENDA localization in branch, click for list of all

beta-catenin destruction complex part of

part of

part of

72 BRENDA localization in branch, click for list of all

Tree view

Gene ontology

biological_process is a

is a

cellular_component is a

is a

is a

cellular anatomical entity is a

is a

is a

698 BRENDA localization in branch, click for list of all

is a

acrosomal matrix is a

is a

695 BRENDA localization in branch, click for list of all

actin body is a

is a

is a

694 BRENDA localization in branch, click for list of all

actin filament branch point is a

is a

actin filament bundle is a

is a

actin fusion focus is a

is a

actomyosin is a

is a

688 BRENDA localization in branch, click for list of all

actomyosin contractile ring, distal actin filament layer is a

is a

actomyosin contractile ring, intermediate layer is a

is a

actomyosin contractile ring, proximal layer is a

is a

alae of collagen and cuticulin-based cuticle extracellular matrix is a

is a

annular furrow extracellular matrix is a

is a

annuli extracellular matrix is a

is a

apical complex is a

is a

687 BRENDA localization in branch, click for list of all

apical cytoplasm is a

is a

apical lamina of hyaline layer is a

is a

apical part of cell is a

is a

682 BRENDA localization in branch, click for list of all

ascus epiplasm is a

is a

is a

axon collateral is a

is a

680 BRENDA localization in branch, click for list of all

axon hillock is a

is a

679 BRENDA localization in branch, click for list of all

axon initial segment is a

is a

678 BRENDA localization in branch, click for list of all

axonemal basal plate is a

is a

axonemal central apparatus is a

is a

axonemal outer doublet is a

is a

is a

673 BRENDA localization in branch, click for list of all

bacterial biofilm matrix surface is a

is a

bacterial-type flagellum basal body is a

is a

bacterial-type flagellum filament is a

is a

bacterial-type flagellum hook is a

is a

bacterial-type flagellum hook-filament junction is a

is a

basal labyrinth is a

is a

basal layer of collagen and cuticulin-based cuticle extracellular matrix is a

is a

basal part of cell is a

is a

basolateral cytoplasm is a

is a

bilobe structure is a

is a

blood microparticle is a

is a

bridge contact site is a

is a

Casparian strip is a

is a

is a

668 BRENDA localization in branch, click for list of all

cell division site is a

is a

666 BRENDA localization in branch, click for list of all

cell junction is a

is a

661 BRENDA localization in branch, click for list of all

cell leading edge is a

is a

cell periphery is a

is a

644 BRENDA localization in branch, click for list of all

cell plate is a

is a

467 BRENDA localization in branch, click for list of all

is a

466 BRENDA localization in branch, click for list of all

cell projection is a

is a

cell septum is a

is a

459 BRENDA localization in branch, click for list of all

cell surface is a

is a

458 BRENDA localization in branch, click for list of all

is a

cell trailing edge is a

is a

cellular bud is a

is a

central element is a

is a

456 BRENDA localization in branch, click for list of all

central plaque of spindle pole body is a

is a

centriolar satellite is a

is a

centrosomal corona is a

is a

is a

455 BRENDA localization in branch, click for list of all

is a

454 BRENDA localization in branch, click for list of all

chromosomal region is a

is a

435 BRENDA localization in branch, click for list of all

is a

compact myelin is a

is a

429 BRENDA localization in branch, click for list of all

concave side of sperm head is a

is a

cone matrix sheath is a

is a

contact site is a

is a

428 BRENDA localization in branch, click for list of all

contractile ring is a

is a

427 BRENDA localization in branch, click for list of all

cortical layer of collagen and cuticulin-based cuticle extracellular matrix is a

is a

is a

cytoophidium is a

is a

426 BRENDA localization in branch, click for list of all

is a

425 BRENDA localization in branch, click for list of all

acetolactate synthase complex part of

part of

177 BRENDA localization in branch, click for list of all

acetyl-CoA carboxylase complex part of

part of

acidocalcisome part of

part of

176 BRENDA localization in branch, click for list of all

ADPG pyrophosphorylase complex part of

part of

alkyl hydroperoxide reductase complex part of

part of

175 BRENDA localization in branch, click for list of all

alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) part of

part of

anaerobic ribonucleoside-triphosphate reductase complex part of

part of

anammoxosome part of

part of

174 BRENDA localization in branch, click for list of all

anthranilate synthase complex part of

part of

173 BRENDA localization in branch, click for list of all

APC-tubulin-IQGAP1 complex part of

part of

Atg1/ULK1 kinase complex part of

part of

Atg12-Atg5-Atg16 complex part of

part of

beta-catenin destruction complex part of

part of

calpain complex part of

part of

carbamoyl-phosphate synthase complex part of

part of

CBM complex part of

part of

Cdc42 GTPase complex part of

part of

citrate lyase complex part of

part of

172 BRENDA localization in branch, click for list of all

contractile fiber part of

part of

CRD-mediated mRNA stability complex part of

part of

crystalloid part of

part of

163 BRENDA localization in branch, click for list of all

CUGBP1-eIF2 complex part of

part of

Cvt complex part of

part of

cysteine synthase complex part of

part of

162 BRENDA localization in branch, click for list of all

cytoplasmic chromosome part of

part of

cytoplasmic cyclin-dependent protein kinase holoenzyme complex part of

part of

cytoplasmic exosome (RNase complex) part of

part of

cytoplasmic microtubule part of

part of

cytoplasmic microtubule bundle part of

part of

cytoplasmic region is a

is a

155 BRENDA localization in branch, click for list of all

cytoplasmic ribonucleoprotein granule part of

part of

cytoplasmic transcription factor complex part of

part of

cytoplasmic transcriptional repressor complex part of

part of

cytoplasmic U snRNP body part of

part of

cytoplasmic ubiquitin ligase complex part of

part of

cytoplasmic vesicle part of

part of

150 BRENDA localization in branch, click for list of all

part of

128 BRENDA localization in branch, click for list of all

dense body part of

part of

DNA gyrase complex part of

part of

DNA topoisomerase IV complex part of

part of

part of

120 BRENDA localization in branch, click for list of all

electron transfer flavoprotein complex part of

part of

endoplasmic reticulum-Golgi intermediate compartment part of

part of

eukaryotic translation elongation factor 1 complex part of

part of

eukaryotic translation initiation factor 2 complex part of

part of

eukaryotic translation initiation factor 2B complex part of

part of

eukaryotic translation initiation factor 3 complex part of

part of

eukaryotic translation initiation factor 4F complex part of

part of

FHF complex part of

part of

part of

118 BRENDA localization in branch, click for list of all

G-protein beta/gamma-Btk complex part of

part of

G-protein beta/gamma-Raf-1 complex part of

part of

G-protein beta/gamma-subunit complex part of

part of

glutamate-cysteine ligase complex part of

part of

glutamate-tRNA ligase complex part of

part of

glycerol-3-phosphate dehydrogenase complex part of

part of

117 BRENDA localization in branch, click for list of all

glycine cleavage complex part of

part of

116 BRENDA localization in branch, click for list of all

glycine reductase complex part of

part of

115 BRENDA localization in branch, click for list of all

glycine-tRNA ligase complex part of

part of

glycogen granule part of

part of

114 BRENDA localization in branch, click for list of all

glycolate oxidase complex part of

part of

goblet cell theca part of

part of

histone mRNA stem-loop binding complex part of

part of

homodimeric decaprenyl diphosphate synthase complex part of

part of

homomeric SMAD protein complex part of

part of

HSP90-CDC37 chaperone complex part of

part of

hydrogenosome part of

part of

113 BRENDA localization in branch, click for list of all

imidazoleglycerol-phosphate synthase complex part of

part of

keratohyalin granule part of

part of

membrane coat part of

part of

methane-oxidizing organelle part of

part of

methionyl glutamyl tRNA synthetase complex part of

part of

methylosome part of

part of

part of

108 BRENDA localization in branch, click for list of all

mitochondrial cloud part of

part of

99 BRENDA localization in branch, click for list of all

mitochondrion part of

part of

98 BRENDA localization in branch, click for list of all

part of

81 BRENDA localization in branch, click for list of all

mitotic spindle assembly checkpoint MAD1-MAD2 complex part of

part of

monolayer-surrounded lipid storage body outer lipid monolayer part of

part of

multi-eIF complex part of

part of

Myo2p-Vac17p-Vac8p transport complex part of

part of

N-terminal protein acetyltransferase complex part of

part of

nascent polypeptide-associated complex part of

part of

neurofilament part of

part of

80 BRENDA localization in branch, click for list of all

is a

79 BRENDA localization in branch, click for list of all

ornithine carbamoyltransferase complex part of

part of

PAN complex part of

part of

Par3-APC-KIF3A complex part of

part of

paraferritin complex part of

part of

perinuclear region of cytoplasm part of

part of

periphagosomal region of cytoplasm part of

part of

PHA granule part of

part of

78 BRENDA localization in branch, click for list of all

phagophore part of

part of

77 BRENDA localization in branch, click for list of all

phagophore assembly site part of

part of

phenylalanine-tRNA ligase complex part of

part of

phosphoenolpyruvate-dependent sugar phosphotransferase complex part of

part of

phosphopantothenoylcysteine decarboxylase complex part of

part of

phosphoribosylaminoimidazole carboxylase complex part of

part of

phosphorylase kinase complex part of

part of

76 BRENDA localization in branch, click for list of all

phragmoplast part of

part of

75 BRENDA localization in branch, click for list of all

phragmosome part of

part of

74 BRENDA localization in branch, click for list of all

pICln-Sm protein complex part of

part of

pirellulosome part of

part of

plasma membrane-derived chromatophore part of

part of

part of

72 BRENDA localization in branch, click for list of all

amyloplast is a

is a

39 BRENDA localization in branch, click for list of all

apicoplast is a

is a

37 BRENDA localization in branch, click for list of all

chloroplast is a

is a

36 BRENDA localization in branch, click for list of all

chromoplast is a

is a

19 BRENDA localization in branch, click for list of all

is a

17 BRENDA localization in branch, click for list of all

is a

15 BRENDA localization in branch, click for list of all

gerontoplast is a

is a

11 BRENDA localization in branch, click for list of all

leucoplast is a

is a

9 BRENDA localization in branch, click for list of all

nucleomorph part of

part of

8 BRENDA localization in branch, click for list of all

phenyloplast is a

is a

7 BRENDA localization in branch, click for list of all

plastid envelope part of

part of

6 BRENDA localization in branch, click for list of all

plastid mRNA editing complex part of

part of

plastid pyruvate dehydrogenase complex part of

part of

4 BRENDA localization in branch, click for list of all

plastid stroma part of

part of

3 BRENDA localization in branch, click for list of all

plastid thylakoid part of

part of

plastid-encoded plastid RNA polymerase complex part of

part of

proplastid is a

is a

1 BRENDA localization in branch, click for list of all

part of

starch grain part of

part of

31 BRENDA localization in branch, click for list of all

pole plasm is a

is a

30 BRENDA localization in branch, click for list of all

part of

polyketide synthase complex part of

part of

preprophase band part of

part of

28 BRENDA localization in branch, click for list of all

procentriole part of

part of

procentriole replication complex part of

part of

protein body part of

part of

27 BRENDA localization in branch, click for list of all

protein farnesyltransferase complex part of

part of

protein phosphatase type 1 complex part of

part of

protein-N(PI)-phosphohistidine-sugar phosphotransferase complex part of

part of

pyruvate dehydrogenase (lipoamide) phosphatase complex part of

part of

pyruvate dehydrogenase complex part of

part of

26 BRENDA localization in branch, click for list of all

Rab-protein geranylgeranyltransferase complex part of

part of

RasGAP-Fyn-Lyn-Yes complex part of

part of

RAVE complex part of

part of

25 BRENDA localization in branch, click for list of all

ribulose bisphosphate carboxylase complex part of

part of

sarcoplasm is a

is a

24 BRENDA localization in branch, click for list of all

sarcosine oxidase complex part of

part of

SCAR complex part of

part of

scintillon part of

part of

23 BRENDA localization in branch, click for list of all

Scrib-APC complex part of

part of

Scrib-APC-beta-catenin complex part of

part of

serine-pyruvate aminotransferase complex part of

part of

Sid2-Mob1 complex part of

part of

signal recognition particle part of

part of

22 BRENDA localization in branch, click for list of all

Ski complex part of

part of

21 BRENDA localization in branch, click for list of all

SMN-Sm protein complex part of

part of

SNARE complex part of

part of

20 BRENDA localization in branch, click for list of all

spectrosome part of

part of

sulfate adenylyltransferase complex (ATP) part of

part of

thioglucosidase complex part of

part of

translation initiation complex part of

part of

19 BRENDA localization in branch, click for list of all

translation initiation ternary complex part of

part of

translation preinitiation complex part of

part of

translation release factor complex part of

part of

transnitrosylase complex part of

part of

tricarboxylic acid cycle enzyme complex part of

part of

type I site-specific deoxyribonuclease complex part of

part of

type II site-specific deoxyribonuclease complex part of

part of

type III site-specific deoxyribonuclease complex part of

part of

type IV site-specific deoxyribonuclease complex part of

part of

UFD1-NPL4 complex part of

part of

urease complex part of

part of

17 BRENDA localization in branch, click for list of all

vacuolar transporter chaperone complex part of

part of

part of

16 BRENDA localization in branch, click for list of all

VCP-NSFL1C complex part of

part of

viral assembly compartment part of

part of

viral assembly intermediate part of

part of

WASH complex part of

part of

part of

deep fiber is a

is a

dense fibrillar component is a

is a

245 BRENDA localization in branch, click for list of all

dense nuclear body is a

is a

dinoflagellate antapex is a

is a

dinoflagellate apex is a

is a

dinoflagellate epicone is a

is a

dinoflagellate hypocone is a

is a

DNA replication termination region is a

is a

is a

244 BRENDA localization in branch, click for list of all

endonuclear canal is a

is a

243 BRENDA localization in branch, click for list of all

endospore core is a

is a

ensheathing process is a

is a

is a

242 BRENDA localization in branch, click for list of all

epicuticle of collagen and cuticulin-based cuticle extracellular matrix is a

is a

extra-invasive hyphal space is a

is a

extracellular matrix is a

is a

241 BRENDA localization in branch, click for list of all

extracellular region is a

is a

226 BRENDA localization in branch, click for list of all

extrachromosomal circular DNA is a

is a

208 BRENDA localization in branch, click for list of all

extrachromosomal DNA is a

is a

207 BRENDA localization in branch, click for list of all

extrinsic component of membrane is a

is a

fibrillar center is a

is a

Flemming body is a

is a

gas vesicle shell is a

is a

is a

205 BRENDA localization in branch, click for list of all

granular component is a

is a

204 BRENDA localization in branch, click for list of all

half bridge of spindle pole body is a

is a

host cellular component is a

is a

incipient cellular bud site is a

is a

inclusion body is a

is a

189 BRENDA localization in branch, click for list of all

inner membrane pellicle complex is a

is a

inner plaque of spindle pole body is a

is a

intermediate layer of spindle pole body is a

is a

intracellular immature spore is a

is a

intrinsic component of membrane is a

is a

investment cone is a

is a

lateral element is a

is a

lateral loop is a

is a

lateral part of cell is a

is a

leaflet of membrane bilayer is a

is a

is a

180 BRENDA localization in branch, click for list of all

median body is a

is a

is a

179 BRENDA localization in branch, click for list of all

membrane-enclosed lumen is a

is a

metaphase plate is a

is a

119 BRENDA localization in branch, click for list of all

microtubule bundle is a

is a

microtubule end is a

is a

118 BRENDA localization in branch, click for list of all

microtubule organizing center is a

is a

116 BRENDA localization in branch, click for list of all

is a

110 BRENDA localization in branch, click for list of all

myelin sheath is a

is a

109 BRENDA localization in branch, click for list of all

neck portion of tanycyte is a

is a

is a

108 BRENDA localization in branch, click for list of all

nucleus lagging edge is a

is a

nucleus leading edge is a

is a

oral apparatus is a

is a

106 BRENDA localization in branch, click for list of all

is a

105 BRENDA localization in branch, click for list of all

is a

17 BRENDA localization in branch, click for list of all

periplasmic space is a

is a

16 BRENDA localization in branch, click for list of all

photoreceptor inner segment is a

is a

15 BRENDA localization in branch, click for list of all

polar tube is a

is a

14 BRENDA localization in branch, click for list of all

postsynapse is a

is a

presynapse is a

is a

site of polarized growth is a

is a

somatodendritic compartment is a

is a

sperm head is a

is a

12 BRENDA localization in branch, click for list of all

sperm head-tail coupling apparatus is a

is a

sporoplasm is a

is a

supramolecular complex is a

is a

11 BRENDA localization in branch, click for list of all

is a

10 BRENDA localization in branch, click for list of all

is a

9 BRENDA localization in branch, click for list of all

tail portion of tanycyte is a

is a

is a

2 BRENDA localization in branch, click for list of all

is a

intracellular is a

is a

70 BRENDA localization in branch, click for list of all

other organism part is a

is a

protein-containing complex is a

is a

46 BRENDA localization in branch, click for list of all

is a

8 BRENDA localization in branch, click for list of all

molecular_function is a

is a