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Gene ontology
Version 2014-12-22
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Details for beta-catenin destruction complex
Gene ontology ID
GO:0030877
Definition
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome
Comment
Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'.
Synonyms
1. 23S APC complex
2. APC-Axin-1-beta-catenin complex
3. Axin-APC-beta-catenin-GSK3B complex
4. BDC
5. beta-catenin degradation complex
References
1. PMID 14600025
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Gene ontology
cellular_component is a
cellular anatomical entity is a
peg and socket contact is a
inner dense plaque of desmosome part of
cytoplasm is a413 BRENDA localization in branch, click for list of all
beta-catenin destruction complex part of
osmiophilic body is a
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex is a