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Gene ontology
Version 2014-12-22
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Details for interleukin-27 complex
Gene ontology ID
GO:0070744
Definition
A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space
Comment
Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits.
Synonyms
1. EBI3
2. IL-27 complex
3. IL27
4. p28
References
1. GOC: add
2. PMID 15999093
3. PMID 19161428
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