Gene ontology ID
GO:1990788
Definition
A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins
Comment
An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay).
References
1. GOC: bhm
2. PMID 243115973. IntAct: EBI-10170144
4. IntAct: EBI-10828915
5. IntAct: EBI-10828948
6. IntAct: EBI-10828976
7. IntAct: EBI-10828997
8. IntAct: EBI-10829035
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
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at least 1 tissue/ enzyme/ localization link in this branch
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tissue/ enzyme/ localization link to BRENDA