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BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
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Details for mutator focus
Gene ontology ID
GO:1990633
Definition
A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules
References
1. GOC: kmv
2. PMID 22713602
3. PMID 25635455
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