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Gene ontology
Version 2014-12-22
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Details for trimethyllysine dioxygenase activity
1.14.11.8
Gene ontology ID
GO:0050353
Definition
Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate
Synonyms
1. 6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
2. epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity
3. N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
4. TML dioxygenase activity
5. TML hydroxylase activity
6. TML-alpha-ketoglutarate dioxygenase activity
7. TMLD activity
8. trimethyllysine alpha-ketoglutarate dioxygenase activity
9. trimethyllysine,2-oxoglutarate dioxygenase activity
References
1. EC 1.14.11.8
2. RHEA: 14181
3. KEGG REACTION: R03451
4. MetaCyc TRIMETHYLLYSINE-DIOXYGENASE-RXN
5. Reactome: R-HSA-71241 "TMLHE dimer dioxygenates TMLYS and 2OG to form HTMLYS and SUCCA"
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