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Gene ontology
Version 2014-12-22
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Details for acireductone synthase activity
3.1.3.77
Gene ontology ID
GO:0043874
Definition
Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate
Comment
This function is involved in the process of methionine salvage.
Synonyms
1. 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)
2. E-1
3. E-1 enolase-phosphatase
References
1. EC 3.1.3.77
2. RHEA: 21700
3. MetaCyc 3.1.3.77-RXN
4. Reactome: R-HSA-1237129 "Acireductone is created"
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