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Gene ontology
Version 2014-12-22
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Details for dihydrofolate reductase activity
1.5.1.3
Gene ontology ID
GO:0004146
Definition
Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
Synonyms
1. 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity
2. 7,8-dihydrofolate reductase activity
3. DHFR
4. dihydrofolate reductase:thymidylate synthase activity
5. dihydrofolate reduction
6. dihydrofolic acid reductase activity
7. dihydrofolic reductase activity
8. folic acid reductase activity
9. folic reductase activity
10. NADPH-dihydrofolate reductase activity
11. pteridine reductase:dihydrofolate reductase activity
12. tetrahydrofolate dehydrogenase activity
13. thymidylate synthetase-dihydrofolate reductase activity
References
1. EC 1.5.1.3
2. MetaCyc DIHYDROFOLATEREDUCT-RXN
3. Reactome: R-HSA-1497794 "Salvage - BH2 is reduced to BH4 by DHFR"
4. RHEA: 15009
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