6.3.2.3Gene ontology ID
GO:0004363
Definition
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate
Synonyms
1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. glutathione synthetase activity
3. GSH synthetase activity
References
1. EC 6.3.2.32. RHEA: 13557
3. KEGG REACTION: R00497
4. MetaCyc GLUTATHIONE-SYN-RXN5. Reactome: R-HSA-174394 "GSS:Mg2+ dimer synthesizes GSH"
6. Reactome: R-HSA-5602901 "Defective GSS does not synthesize GSH"
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derives from the parent element
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