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Version 2014-12-22
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Details for malate dehydrogenase (decarboxylating) (NADP+) activity
1.1.1.40
Gene ontology ID
GO:0004473
Definition
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+
Comment
For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'.
Synonyms
1. 'malic' enzyme
2. (S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
3. L-malate:NADP oxidoreductase activity
4. malate dehydrogenase (decarboxylating, NADP)
5. malate dehydrogenase (NADP, decarboxylating)
6. NADP-linked decarboxylating malic enzyme
7. NADP-malic enzyme activity
8. NADP-specific malate dehydrogenase activity
9. NADP-specific malic enzyme
References
1. EC 1.1.1.40
2. KEGG REACTION: R00216
3. MetaCyc MALIC-NADP-RXN
4. Reactome: R-HSA-9012036 "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR"
5. Reactome: R-HSA-9012349 "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR"
6. RHEA: 18253
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