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Gene ontology
Version 2014-12-22
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Details for 2-oxoglutarate-dependent dioxygenase activity
1.14.11
Gene ontology ID
GO:0016706
Definition
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor
Synonyms
1. 2-oxoglutarate dioxygenase activity
2. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
References
1. GOC: mah
2. EC 1.14.11
3. Reactome: R-HSA-1234164 "Cytosolic HIF1AN (FIH1) hydroxylates asparagine residues of Hypoxia-inducible Factor Alpha (HIF1A,HIF2A)"
4. Reactome: R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)"
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