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Gene ontology
Version 2014-12-22
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Details for regulation of molecular function, epigenetic
Gene ontology ID
GO:0040030
Definition
Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya
Synonyms
1. regulation of protein activity, epigenetic
References
1. GOC: dph
2. GOC: ems
3. GOC: tb
4. PMID 10611975
5. PMID 11050225
6. PMID 11447696
7. PMID 11685242
8. PMID 11782551
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is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
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Condensed Tree View
Gene ontology
biological_process is a
biological regulation is a
regulation of molecular function is a
regulation of molecular function, epigenetic is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
regulation of biological quality is a
regulation of molecular function is a
modulation by symbiont of host molecular function is a
molecular function regulator part of
negative regulation of molecular function is a
positive regulation of molecular function is a
regulation of binding is a
regulation of catalytic activity is a
regulation of molecular function, epigenetic is a
regulation of RNA binding transcription factor activity is a
regulation of transporter activity is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
Atg8 ligase activity is a
CDP-alcohol phosphotransferase activity is a
glucanosyltransferase activity is a
Kdo transferase activity is a
mannosylphosphate transferase activity is a
molybdopterin molybdotransferase activity is a
transferase activity, transferring acyl groups is a
transferase activity, transferring acyl groups other than amino-acyl groups is a
(Z)-3-hexen-1-ol acetyltransferase activity is a
13-hydroxylupinine O-tigloyltransferase activity is a
2,3-diaminopropionate N-oxalyltransferase activity is a
2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity is a
2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity is a
2-alpha-hydroxytaxane 2-O-benzoyltransferase activity is a
2-ketobutyrate formate-lyase activity is a
2-methylhexanoyl-CoA C-acetyltransferase activity is a
2-phenylethanol acetyltransferase activity is a
3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity is a
3-hydroxybutyryl-CoA thiolase activity is a
3-keto-5-aminohexanoate cleavage activity is a
3-ketopimelyl-CoA thiolase activity is a
3-oxo-arachidoyl-CoA synthase activity is a
3-oxo-cerotoyl-CoA synthase activity is a
3-oxo-lignoceronyl-CoA synthase activity is a
3-oxoadipyl-CoA thiolase activity is a
4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity is a
4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity is a
4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity is a
4-coumaroylhexanoylmethane synthase activity is a
4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity is a
5-pentadecatrienylresorcinol synthase activity is a
6'-deoxychalcone synthase activity is a
6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity is a
6-methylsalicylic acid synthase activity is a
8-amino-7-oxononanoate synthase activity is a
acetoacetyl-ACP synthase activity is a
acetyl-coenzyme A:acetyl alcohol acetyltransferase activity is a
acetyltransferase activity is a
acridone synthase activity is a
acrylate:acyl-coA CoA transferase activity is a
acyl coenzyme A: isopenicillin N acyltransferase activity is a
acyl-phosphate glycerol-3-phosphate acyltransferase activity is a
agmatine N4-coumaroyltransferase activity is a
alcohol O-cinnamoyltransferase activity is a
anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity is a
anthocyanin 5-aromatic acyltransferase activity is a
anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity is a
anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity is a
anthocyanin 6''-O-malonyltransferase activity is a
anthranilate N-benzoyltransferase activity is a
arachidoyl-CoA:1-dodecanol O-acyltransferase activity is a
benzoyl acetate-CoA thiolase activity is a
beta-glucogallin O-galloyltransferase activity is a
beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity is a
beta-ketoacyl-acyl-carrier-protein synthase II activity is a
beta-ketoacyl-acyl-carrier-protein synthase III activity is a
biphenyl synthase activity is a
bisdemethoxycurcumin synthase activity is a
butanoyltransferase activity is a
butyryl-CoA 2-C-propionyltransferase activity is a
C-acyltransferase activity is a
caffeoyl-CoA: alcohol caffeoyl transferase activity is a
caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity is a
caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity is a
caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity is a
chalcone synthase activity is a
CO-methylating acetyl-CoA synthase activity is a
curcumin synthase activity is a
cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity is a
cyanidin 3-O-glucoside 6''-O-malonyltransferase activity is a
cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity is a
cyanidin 3-O-glucoside-p-coumaroyltransferase activity is a
cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity is a
cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity is a
cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity is a
cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity is a
cysteine-S-conjugate N-malonyl transferase activity is a
decanoyltransferase activity is a
delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity is a
delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity is a
demethoxycurcumin synthase is a
demethoxycurcumin synthase activity is a
demethoxycurcumin synthase activity from feruloylacetyl-CoA is a
diacylglycerol transacylase activity is a
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity is a
erythronolide synthase activity is a
fatty acid synthase activity is a
fatty-acyl-[acp] elongase/decarboxylase activity is a
flavonol-3-O-triglucoside O-coumaroyltransferase activity is a
gamma-linolenate elongase activity is a
glutamine N-phenylacetyltransferase activity is a
glycero-3-phosphocholine acyltransferase activity is a
glycerophospholipid acyltransferase (CoA-dependent) activity is a
glycerophospholipid arachidonoyl-transferase (CoA-independent) activity is a
glycine N-benzoyltransferase activity is a
glycine N-choloyltransferase activity is a
heptadecanoyl-[acp] elongase/decarboxylase activity is a
hexanoyltransferase activity is a
hydroxycinnamoyltransferase activity is a
icosanoyl-CoA synthase activity is a
isocitrate O-dihydroxycinnamoyltransferase activity is a
keto acid formate lyase activity is a
lauroyltransferase activity is a
lecithin:11-cis retinol acyltransferase activity is a
lipoyl(octanoyl) transferase activity is a
lipoyltransferase activity is a
lovastatin nonaketide synthase activity is a
lysophospholipid acyltransferase activity is a
malonyl-malonyl acyl carrier protein-condensing enzyme activity is a
malonyltransferase activity is a
methione N-acyltransferase activity is a
mycocerosate synthase activity is a
mycothiol synthase activity is a
myristoyltransferase activity is a
N(6)-L-threonylcarbamoyladenine synthase activity is a
N-acyltransferase activity is a
naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity is a
naringenin-chalcone synthase activity is a
norsolorinate anthrone synthase activity is a
O-acyltransferase activity is a
1-acylglycerophosphocholine O-acyltransferase activity is a
1-alkenylglycerophosphocholine O-acyltransferase activity is a
1-alkenylglycerophosphoethanolamine O-acyltransferase activity is a
1-alkyl-2-acetylglycerol O-acyltransferase activity is a
1-alkylglycerophosphocholine O-acyltransferase activity is a
2-acylglycerophosphocholine O-acyltransferase activity is a
acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity is a
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity is a
acylglycerol O-acyltransferase activity is a
alcohol O-acyltransferase activity is a
carnitine O-acyltransferase activity is a
diacylglycerol-sterol O-acyltransferase activity is a
dolichol O-acyltransferase activity is a
ecdysone O-acyltransferase activity is a
galactolipid O-acyltransferase activity is a
galactosylacylglycerol O-acyltransferase activity is a
glucosaminyl-phosphatidylinositol O-acyltransferase activity is a
glycerol-3-phosphate 2-O-acyltransferase activity is a
glycerol-3-phosphate O-acyltransferase activity is a
indoleacetylglucose-inositol O-acyltransferase activity is a
long-chain-alcohol O-fatty-acyltransferase activity is a
O-linoleoyltransferase activity is a
O-octanoyltransferase activity is a
O-palmitoyltransferase activity is a
myelin-proteolipid O-palmitoyltransferase activity is a
O-sinapoyltransferase activity is a
O-succinyltransferase activity is a
phosphatidate-sterol O-acyltransferase activity is a
phosphatidylcholine-dolichol O-acyltransferase activity is a
phosphatidylcholine-retinol O-acyltransferase activity is a
phosphatidylcholine-sterol O-acyltransferase activity is a
phosphatidylethanolamine-sterol O-acyltransferase activity is a
serine O-acyltransferase activity is a
sterol O-acyltransferase activity is a
triglyceride-sterol O-acyltransferase activity is a
octanoyltransferase activity is a
omega-hydroxypalmitate O-sinapoyl transferase activity is a
ornithine N-benzoyltransferase activity is a
ornithine N-delta-acetyltransferase activity is a
p-coumaroyltriacetic acid lactone synthase activity is a
p-coumaroyltriacetic acid synthase activity is a
palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity is a
palmitoleoyltransferase activity is a
palmitoyl-[acp] elongase/decarboxylase activity is a
palmitoyltransferase activity is a
phenylacetyl-coenzyme A:glycine N-acyltransferase activity is a
phenylpropanoyltransferase activity is a
phloroisovalerophenone synthase activity is a
phosphate butyryltransferase activity is a
phosphate:acyl-[acyl carrier protein] acyltransferase activity is a
phosphinothricin N-acetyltransferase activity is a
pinosylvin synthase activity is a
piperidine N-piperoyltransferase activity is a
plasmalogen synthase activity is a
propionyl-CoA C2-trimethyltridecanoyltransferase activity is a
pyruvyltransferase activity is a
rosmarinate synthase activity is a
S-acyltransferase activity is a
sinapoyltransferase activity is a
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity is a
stearoyl-[acp] elongase/decarboxylase activity is a
succinyltransferase activity is a
tetrahydroxybenzophenone synthase activity is a
tetraketide alpha-pyrone synthase activity is a
trehalose O-mycolyltransferase activity is a
trihydroxybenzophenone synthase activity is a
trihydroxystilbene synthase activity is a
tyramine N-feruloyltransferase activity is a
UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity is a
very-long-chain 3-ketoacyl-CoA synthase activity is a
vinorine synthase activity is a
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer is a
transferase activity, transferring aldehyde or ketonic groups is a
transferase activity, transferring alkyl or aryl (other than methyl) groups is a
transferase activity, transferring glycosyl groups is a
transferase activity, transferring nitrogenous groups is a
transferase activity, transferring one-carbon groups is a
transferase activity, transferring phosphorus-containing groups is a
transferase activity, transferring selenium-containing groups is a
transferase activity, transferring sulfur-containing groups is a
UDP-L-rhamnose synthase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a