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Version 2014-12-22
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Details for guanyl-nucleotide exchange factor activity
Gene ontology ID
GO:0005085
Definition
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase
Comment
Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
Synonyms
1. GDP-dissociation stimulator activity
2. GDS
3. GEF
4. GNRP
5. guanyl-nucleotide release factor activity
6. guanyl-nucleotide releasing factor
References
1. GOC: kd
2. GOC: mah
3. MIPS funcat: 18.02.03
4. Reactome: R-HSA-114544 "p115-RhoGEF activation of RHOA"
5. Reactome: R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP"
6. Reactome: R-HSA-1433415 "Activation of RAC1"
7. Reactome: R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity"
8. Reactome: R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1"
9. Reactome: R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1"
10. Reactome: R-HSA-187746 "RIT/RIN are activated"
11. Reactome: R-HSA-2029445 "Activation of CDC42 by unknown mechanism"
12. Reactome: R-HSA-2029451 "Activation of RAC1 by VAV"
13. Reactome: R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO"
14. Reactome: R-HSA-203977 "SAR1 Activation And Membrane Binding"
15. Reactome: R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor"
16. Reactome: R-HSA-2424476 "Activation of RAC1 by VAV2/3"
17. Reactome: R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt"
18. Reactome: R-HSA-2730840 "Activation of RAC1 by VAV"
19. Reactome: R-HSA-354173 "Activation of Rap1 by cytosolic GEFs"
20. Reactome: R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs"
21. Reactome: R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11"
22. Reactome: R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi"
23. Reactome: R-HSA-389348 "Activation of Rac1 by pVav1"
24. Reactome: R-HSA-389350 "Activation of Cdc42 by pVav1"
25. Reactome: R-HSA-392195 "Gi activation by P2Y purinoceptor 12"
26. Reactome: R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it"
27. Reactome: R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it"
28. Reactome: R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it"
29. Reactome: R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it"
30. Reactome: R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it"
31. Reactome: R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it"
32. Reactome: R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA"
33. Reactome: R-HSA-392870 "Gs activation by prostacyclin receptor"
34. Reactome: R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange"
35. Reactome: R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq"
36. Reactome: R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it"
37. Reactome: R-HSA-416530 "GPR40:fatty acid activates Gq"
38. Reactome: R-HSA-418579 "Gq activation by P2Y purinoceptor 1"
39. Reactome: R-HSA-420883 "Opsins act as GEFs for G alpha-t"
40. Reactome: R-HSA-428750 "Gq activation by TP receptor"
41. Reactome: R-HSA-428917 "G13 activation by TP receptor"
42. Reactome: R-HSA-442273 "VAV1 is a GEF for Rho/Rac family GTPases"
43. Reactome: R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases"
44. Reactome: R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases"
45. Reactome: R-HSA-445064 "Activation of Rac1 by VAV2"
46. Reactome: R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism"
47. Reactome: R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1"
48. Reactome: R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it"
49. Reactome: R-HSA-5694409 "Nucleotide exchange on RAB1"
50. Reactome: R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange"
51. Reactome: R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange"
52. Reactome: R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz"
53. Reactome: R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13"
54. Reactome: R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange"
55. Reactome: R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex"
56. Reactome: R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18"
57. Reactome: R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1"
58. Reactome: R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET"
59. Reactome: R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET"
60. Reactome: R-HSA-8875568 "RAPGEF1 activates RAP1"
61. Reactome: R-HSA-8875591 "DOCK7 activates RAC1"
62. Reactome: R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated"
63. Reactome: R-HSA-8982637 "Opsins binds G alpha-t"
64. Reactome: R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)"
65. Reactome: R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs"
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// tissue/ enzyme/ localization link to BRENDA
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