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Version 2014-12-22
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Details for thyroxine 5'-deiodinase activity
1.21.99.4
Gene ontology ID
GO:0004800
Definition
Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2
Comment
Note that this was EC:3.8.1.4.
Synonyms
1. acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)
2. diiodothyronine 5'-deiodinase activity
3. iodothyronine 5'-deiodinase activity
4. iodothyronine outer ring monodeiodinase activity
5. L-thyroxine iodohydrolase (reducing) activity
6. outer ring-deiodinating pathway
7. thyroxine 5' deiodinase activity
8. thyroxine deiodinase activity
9. type I iodothyronine deiodinase activity
10. type II iodothyronine deiodinase activity
References
1. EC 1.21.99.4
2. MetaCyc THYROXINE-DEIODINASE-RXN
3. Reactome: R-HSA-209772 "Thyroxine is deiodinated to triiodothyronine"
4. Reactome: R-HSA-350869 "Thyroxine is deiodinated to reverse triiodothyronine (RT3)"
5. RHEA: 19745
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