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Gene ontology
Version 2014-12-22
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Details for prostaglandin-endoperoxide synthase activity
1.14.99.1
Gene ontology ID
GO:0004666
Definition
Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O
Synonyms
1. (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity
2. (PG)H synthase activity
3. fatty acid cyclooxygenase activity
4. PG synthetase activity
5. prostaglandin endoperoxide synthetase activity
6. prostaglandin G/H synthase activity
7. prostaglandin synthase activity
8. prostaglandin synthetase activity
References
1. EC 1.14.99.1
2. MetaCyc PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN
3. Reactome: R-HSA-140355 "Arachidonic acid is oxidised to PGG2 by PTGS1"
4. Reactome: R-HSA-2309787 "Arachidonic acid is oxidised to PGG2 by PTGS2"
5. RHEA: 23728
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