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Version 2014-12-22
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Details for 4-amino-4-deoxychorismate synthase activity
2.6.1.85
Gene ontology ID
GO:0046820
Definition
Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate
Comment
Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate.
References
1. EC 2.6.1.85
2. RHEA: 11675
3. KEGG: R01716
4. MetaCyc PABASYN-RXN
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