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Gene ontology
Version 2014-12-22
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Details for DNA N-glycosylase activity
3.2.2
Gene ontology ID
GO:0019104
Definition
Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site
Synonyms
1. DNA glycosylase activity
2. endonuclease VIII activity
References
1. GOC: elh
2. PMID 11554296
3. EC 3.2.2
4. Reactome: R-HSA-110218 "Cleavage of uracil by TDG glycosylase"
5. Reactome: R-HSA-110219 "Cleavage of thymine by TDG glycosylase"
6. Reactome: R-HSA-110231 "Cleavage of uracil by MBD4 glycosylase"
7. Reactome: R-HSA-110232 "Cleavage of thymine by MBD4 glycosylase"
8. Reactome: R-HSA-110234 "Cleavage of ethenocytosine by TDG glycosylase"
9. Reactome: R-HSA-110246 "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH"
10. Reactome: R-HSA-110248 "Cleavage of 3-methyladenine by MPG glycosylase"
11. Reactome: R-HSA-110250 "Cleavage of ethenoadenine by MPG glycosylase"
12. Reactome: R-HSA-110251 "Cleavage of hypoxanthine by MPG glycosylase"
13. Reactome: R-HSA-5220959 "TDG excises 5-formylcytosine"
14. Reactome: R-HSA-5221061 "TDG excises 5-carboxylcytosine"
15. Reactome: R-HSA-5649658 "NEIL1 cleaves DHU from damaged DNA"
16. Reactome: R-HSA-5649664 "NEIL1 cleaves FapyG from damaged DNA"
17. Reactome: R-HSA-5649673 "NEIL1 cleaves FapyA from damaged DNA"
18. Reactome: R-HSA-5649681 "NEIL2 cleaves 5-OHU from damaged DNA"
19. Reactome: R-HSA-9629149 "NEIL1 cleaves thymine glycol from damaged DNA"
20. Reactome: R-HSA-9629216 "NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA"
21. Reactome: R-HSA-9629470 "NEIL3 cleaves 5-guanidinohydantoin"
22. Reactome: R-HSA-9629483 "NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA"
23. Reactome: R-HSA-9629492 "NEIL3 cleaves spiroiminodihydantoin"
24. Reactome: R-HSA-9629497 "NEIL3 cleaves thymine glycol from telomeric DNA"
25. Reactome: R-HSA-9629499 "NEIL3 cleaves thymine glycol"
26. Reactome: R-HSA-9635996 "NEIL3 resolves psoralen-induced ICLs"
27. Reactome: R-HSA-9636008 "NEIL3 resolves abasic site-induced ICLs"
Legend
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is a part of the parent element
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// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
catalytic activity, acting on DNA is a
DNA N-glycosylase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
5'-deoxyribose-5-phosphate lyase activity is a
deoxyribodipyrimidine endonucleosidase activity is a
DNA alpha-glucosyltransferase activity is a
DNA beta-glucosyltransferase activity is a
DNA N-glycosylase activity is a
DNA nucleotidylexotransferase activity is a
DNA photolyase activity is a
DNA-(apurinic or apyrimidinic site) endonuclease activity is a
DNA-deoxyinosine glycosylase activity is a
DNA/RNA helicase activity is a
phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands is a
transposase activity is a
tyrosyl-DNA phosphodiesterase activity is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
Atg8 ligase activity is a
CDP-alcohol phosphotransferase activity is a
glucanosyltransferase activity is a
Kdo transferase activity is a
mannosylphosphate transferase activity is a
molybdopterin molybdotransferase activity is a
transferase activity, transferring acyl groups is a
transferase activity, transferring aldehyde or ketonic groups is a
transferase activity, transferring alkyl or aryl (other than methyl) groups is a
transferase activity, transferring glycosyl groups is a
transferase activity, transferring nitrogenous groups is a
amidinotransferase activity is a
dATP(dGTP)-DNA purinetransferase activity is a
oximinotransaminase activity is a
pyridoxine 5'-phosphate synthase activity is a
transaminase activity is a
(R)-3-amino-2-methylpropionate-pyruvate transaminase activity is a
(S)-3-amino-2-methylpropionate transaminase activity is a
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity is a
2,5-diaminovalerate transaminase activity is a
2-aminoadipate transaminase activity is a
2-aminoethylphosphonate-pyruvate transaminase activity is a
2-aminohexanoate transaminase activity is a
2-keto-4-methylthiobutyrate aminotransferase activity is a
2-oxo-5-methylthiopentanoate aminotransferase activity is a
2-oxo-6-methylthiohexanoate aminotransferase activity is a
4-amino-4-deoxychorismate synthase activity is a
4-aminobutyrate transaminase activity is a
4-hydroxyglutamate transaminase activity is a
5-aminovalerate transaminase activity is a
6-aminohexanoate transaminase activity is a
acetyldiaminopimelate aminotransferase activity is a
adenosylmethionine-8-amino-7-oxononanoate transaminase activity is a
alanine-glyoxylate transaminase activity is a
alanine-oxo-acid transaminase activity is a
alanine-oxomalonate transaminase activity is a
aminolevulinate transaminase activity is a
aromatic-amino-acid-glyoxylate transaminase activity is a
aromatic-amino-acid:2-oxoglutarate aminotransferase activity is a
asparagine-oxo-acid transaminase activity is a
aspartate-2-keto-4-methylthiobutyrate transaminase activity is a
aspartate-phenylpyruvate transaminase activity is a
aspartate-prephenate aminotransferase activity is a
beta-alanine-pyruvate transaminase activity is a
branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity is a
branched-chain-amino-acid transaminase activity is a
butane-1,4-diamine:2-oxoglutarate aminotransferase activity is a
cephalosporin-C transaminase activity is a
cysteine-conjugate transaminase activity is a
D-4-hydroxyphenylglycine transaminase activity is a
D-alanine:2-oxoglutarate aminotransferase activity is a
D-lysine transaminase activity is a
D-methionine-pyruvate transaminase activity is a
diamine transaminase activity is a
diaminobutyrate-2-oxoglutarate transaminase activity is a
diaminobutyrate-pyruvate transaminase activity is a
dihydroxyphenylalanine transaminase activity is a
diiodotyrosine transaminase activity is a
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity is a
dTDP-4-amino-4,6-dideoxygalactose transaminase activity is a
gamma-aminobutyrate transaminase (glyoxylate dependent) activity is a
GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity is a
glutamate-prephenate aminotransferase activity is a
glycine-oxaloacetate transaminase activity is a
glycine:2-oxoglutarate aminotransferase activity is a
histidinol-phosphate transaminase activity is a
homotaurine:2-oxoglutarate aminotransferase activity is a
L,L-diaminopimelate aminotransferase activity is a
L-aspartate:2-oxoglutarate aminotransferase activity is a
L-cysteine:2-oxoglutarate aminotransferase activity is a
L-glutamine aminotransferase activity is a
L-histidine:2-oxoglutarate aminotransferase activity is a
L-leucine:2-oxoglutarate aminotransferase activity is a
L-lysine 6-transaminase activity is a
L-lysine alpha-aminotransferase is a
L-phenylalanine aminotransferase activity is a
L-tryptophan aminotransferase activity is a
L-tyrosine aminotransferase activity is a
lysine-pyruvate 6-transaminase activity is a
methionine-glyoxylate transaminase activity is a
methionine-oxo-acid transaminase activity is a
N2-acetyl-L-lysine aminotransferase activity is a
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity is a
N6-acetyl-beta-lysine transaminase activity is a
nicotianamine aminotransferase activity is a
O-phospho-L-serine:2-oxoglutarate aminotransferase activity is a
ornithine(lysine) transaminase activity is a
ornithine-oxo-acid transaminase activity is a
pyridoxamine-oxaloacetate transaminase activity is a
pyridoxamine-phosphate transaminase activity is a
pyridoxamine-pyruvate transaminase activity is a
serine-glyoxylate transaminase activity is a
serine-pyruvate transaminase activity is a
succinyldiaminopimelate transaminase activity is a
succinylornithine transaminase activity is a
taurine-2-oxoglutarate transaminase activity is a
taurine-pyruvate aminotransferase activity is a
thyroid-hormone transaminase activity is a
tryptophan-phenylpyruvate transaminase activity is a
tyrosine:phenylpyruvate aminotransferase activity is a
UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity is a
UDP-4-amino-4-deoxy-L-arabinose aminotransferase is a
valine-3-methyl-2-oxovalerate transaminase activity is a
valine-pyruvate transaminase activity is a
transferase activity, transferring one-carbon groups is a
transferase activity, transferring phosphorus-containing groups is a
transferase activity, transferring selenium-containing groups is a
transferase activity, transferring sulfur-containing groups is a
UDP-L-rhamnose synthase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a