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Gene ontology
Version 2014-12-22
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Details for necroptotic signaling pathway
Gene ontology ID
GO:0097527
Definition
A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered
Comment
Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality.
Synonyms
1. necroptosis signaling
2. necroptosis signaling pathway
3. necroptotic signal transduction
4. necroptotic signalling pathway
References
1. GOC: mtg apoptosis
2. PMID 20823910
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Gene ontology
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signal transduction is a
necroptotic signaling pathway is a
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biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
positive regulation of biological process is a
regulation of action potential is a
regulation of asexual reproduction is a
regulation of biomineralization is a
regulation of carbohydrate utilization is a
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regulation of cellular process is a
cell redox homeostasis is a
modulation by symbiont of host cellular process is a
regulation of actin filament-based process is a
regulation of binding of sperm to zona pellucida is a
regulation of cartilage condensation is a
regulation of cell activation is a
regulation of cell adhesion molecule production is a
regulation of cell aging is a
regulation of cell communication is a
regulation of cell cycle is a
regulation of cell death is a
regulation of cell differentiation is a
regulation of cell division is a
regulation of cell killing is a
regulation of cell population proliferation is a
regulation of cell wall organization or biogenesis is a
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regulation of cellular metabolic process is a
regulation of cellular pH reduction is a
regulation of cellular response to alcohol is a
regulation of cellular response to alkaline pH is a
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regulation of cellular response to gamma radiation is a
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regulation of cellular response to insulin stimulus is a
regulation of cellular response to macrophage colony-stimulating factor stimulus is a
regulation of cellular response to manganese ion is a
regulation of cellular response to oxidopamine is a
regulation of cellular response to stress is a
regulation of cellular response to testosterone stimulus is a
regulation of cellular response to thapsigargin is a
regulation of cellular response to tunicamycin is a
regulation of cellular response to very-low-density lipoprotein particle stimulus is a
regulation of cellular response to X-ray is a
regulation of chromosome segregation is a
regulation of conjugation is a
regulation of cytolysis is a
regulation of establishment or maintenance of cell polarity is a
regulation of horizontal cell localization is a
regulation of membrane depolarization is a
regulation of microtubule-based process is a
regulation of myelination is a
regulation of peroxidase activity is a
regulation of phenotypic switching is a
regulation of protein folding is a
regulation of response to cell cycle checkpoint signaling is a
regulation of secretion by cell is a
regulation of single-species biofilm formation is a
regulation of stomatal movement is a
regulation of transmembrane transport is a
regulation of transposition is a
regulation of vacuolar transport is a
regulation of vesicle-mediated transport is a
signal transduction is a
apoptotic signaling pathway is a
bile acid signaling pathway is a
calmodulin dependent kinase signaling pathway is a
carbohydrate mediated signaling is a
cell surface receptor signaling pathway is a
chloroplast-nucleus signaling pathway is a
dopamine receptor signaling pathway is a
endoplasmic reticulum unfolded protein response is a
ER-nucleus signaling pathway is a
extracellular ATP signaling is a
G protein-coupled receptor signaling pathway is a
hormone-mediated signaling pathway is a
hydrogen peroxide mediated signaling pathway is a
hypoxia-inducible factor-1alpha signaling pathway is a
immune response-regulating signaling pathway is a
intracellular receptor signaling pathway is a
intracellular signal transduction is a
ligand-gated ion channel signaling pathway is a
lipoprotein particle mediated signaling is a
mitochondria-nucleus signaling pathway is a
necroptotic signaling pathway is a
neuronal signal transduction is a
osmosensory signaling pathway is a
pattern recognition receptor signaling pathway is a
peptidoglycan recognition protein signaling pathway is a
phototransduction is a
postsynaptic signal transduction is a
presynaptic signal transduction is a
receptor ligand activity part of
red or far-red light signaling pathway is a
regulation of blood pressure by chemoreceptor signaling pathway is a
regulation of floral organ abscission by signal transduction is a
salicylic acid mediated signaling pathway is a
serotonin receptor signaling pathway is a
signal transduction by conformational transition is a
signal transduction by protein phosphorylation is a
signal transduction in absence of ligand is a
signal transduction involved in cellular response to ammonium ion is a
signal transduction involved in filamentous growth is a
signal transduction involved in regulation of gene expression is a
sphingolipid mediated signaling pathway is a
regulation of circadian rhythm is a
regulation of developmental pigmentation is a
regulation of developmental process is a
regulation of estrogen receptor binding is a
regulation of growth is a
regulation of guanyl-nucleotide exchange factor activity is a
regulation of hemostasis is a
regulation of immune system process is a
regulation of interspecies interactions between organisms is a
regulation of localization is a
regulation of locomotion is a
regulation of membrane hyperpolarization is a
regulation of metabolic process is a
regulation of multi-organism process is a
regulation of multicellular organismal process is a
regulation of nitrogen utilization is a
regulation of phosphorus utilization is a
regulation of plasma lipoprotein particle levels is a
regulation of reproductive process is a
regulation of response to stimulus is a
regulation of signaling is a
regulation of sulfur utilization is a
regulation of biological quality is a
regulation of molecular function is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
aspartyl esterase activity is a
carboxylic ester hydrolase activity is a
DNA-3'-diphospho-5'-guanosine diphosphatase is a
enterochelin esterase activity is a
indole-3-acetyl-beta-1-D-glucose hydrolase activity is a
indole-3-acetyl-beta-4-D-glucose hydrolase activity is a
lipase activity is a
phosphoric ester hydrolase activity is a
sulfuric ester hydrolase activity is a
thiolester hydrolase activity is a
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity is a
2-oxoglutaryl-CoA thioesterase activity is a
3-isopropylbut-3-enoyl-CoA thioesterase activity is a
3-oxo-dodecanoyl-ACP hydrolase activity is a
3-oxo-myristoyl-ACP hydrolase activity is a
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3-oxo-palmitoyl-ACP hydrolase activity is a
3-oxoacyl-CoA hydrolase activity is a
acyl-[acyl-carrier-protein] hydrolase activity is a
CoA hydrolase activity is a
(S)-methylmalonyl-CoA hydrolase activity is a
1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity is a
3-hydroxyisobutyryl-CoA hydrolase activity is a
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acetoacetyl-CoA hydrolase activity is a
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phenylacetyl-CoA hydrolase activity is a
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ligase activity is a
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peptidoglycan muralytic activity is a
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nutrient reservoir activity is a
protein tag is a
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transporter activity is a