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Version 2014-12-22
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Details for thiol-dependent ubiquitinyl hydrolase activity
3.4.19.12
Gene ontology ID
GO:0036459
Definition
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin
Comment
20160208: Renamed to thiol-dependent ubiquitinyl hydrolase activity
Synonyms
1. ubiquitin C-terminal hydrolase
2. ubiquitinyl hydrolase 1 activity
3. ubiquitinyl hydrolase activity
References
1. EC 3.4.19.12
2. GOC: bf
3. GOC: ka
4. Reactome: R-HSA-3640872 "USP34 deubiquitinates AXIN1,AXIN2"
5. Reactome: R-HSA-5688797 "ATXN3 family cleave Ub chains"
6. Reactome: R-HSA-5688837 "ATXN3 deubiquitinates polyUb-PARK2"
7. Reactome: R-HSA-5689950 "USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN"
8. Reactome: R-HSA-5689972 "USP2 deubiquitinates MDM2,MDM4"
9. Reactome: R-HSA-5689973 "USP10,USP24,USP42 deubiquitinate TP53"
10. Reactome: R-HSA-5690080 "USP3,SAGA deubiquitinate Histone H2A,H2B"
11. Reactome: R-HSA-5690152 "USP5 cleaves polyubiquitin"
12. Reactome: R-HSA-5690157 "USP16,USP21 deubiquitinate Histone H2A"
13. Reactome: R-HSA-5690159 "USP21 deubiquitinates RIPK1,DDX58"
14. Reactome: R-HSA-5690196 "USP8 deubiquitinates RNF128"
15. Reactome: R-HSA-5690319 "UCHL1, UCHL3 cleave ubiquitin adducts"
16. Reactome: R-HSA-5690759 "BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1"
17. Reactome: R-HSA-5690790 "Histone H2A is dubiquitinated by the PR-DUB complex"
18. Reactome: R-HSA-5691381 "MYSM1 deubiquitinates Histone H2A"
19. Reactome: R-HSA-5696534 "USP18 deubiquitinates TAK1:TAB1"
20. Reactome: R-HSA-5696564 "USP25 deubiquitinates DDX58"
21. Reactome: R-HSA-5696600 "USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1"
22. Reactome: R-HSA-5696605 "USP12, USP26 deubiquitinate AR"
23. Reactome: R-HSA-5696627 "CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG"
24. Reactome: R-HSA-5696872 "USP30 deubiquitinates Ub-MOM proteins"
25. Reactome: R-HSA-5696914 "USP28 deubiquitinates CLSPN and MYC"
26. Reactome: R-HSA-5696945 "USP33 deubiquitinates CCP110,ARRB"
27. Reactome: R-HSA-5696947 "USP47 deubiquitinates POLB"
28. Reactome: R-HSA-5696958 "USP44 deubiquitinates CDC20"
29. Reactome: R-HSA-5696960 "USP49 deubiquitinates H2B"
30. Reactome: R-HSA-5696968 "USP20, USP33 deubiquitinate ADRB2"
31. Reactome: R-HSA-5696997 "USP24 deubiquitinates DDB2"
32. Reactome: R-HSA-5697009 "USP37:RUVLB1:PSMC5 deubiquitinates CCNA1,CCNA2"
33. Reactome: R-HSA-6781764 "USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1"
34. Reactome: R-HSA-6781779 "USP13 deubiquitinates BECN1,USP10"
35. Reactome: R-HSA-6781814 "USP19 deubiquitinates RNF123"
36. Reactome: R-HSA-6781897 "USP11 deubiquitinates NFKBIA"
37. Reactome: R-HSA-6782106 "USP10 deubiquitinates SNX3, CFTR"
38. Reactome: R-HSA-6782628 "USP8 deubiquitinates STAM2:HGS"
39. Reactome: R-HSA-6782820 "USP17 deubiquitinates SUDS3"
40. Reactome: R-HSA-6783177 "USP21 deubiquitinates GATA3,IL33"
41. Reactome: R-HSA-870437 "USP9X (FAM) deubiquitinates SMAD4"
42. Reactome: R-HSA-8862184 "USP48 cleaves polyubiquitin"
43. Reactome: R-HSA-8865182 "OTUD7A hydrolyses K11diUb"
44. Reactome: R-HSA-8869456 "USP4 deubiquitinate TRAF2,TRAF6"
45. Reactome: R-HSA-8873946 "OTUD3 deubiquitinates PTEN"
46. Reactome: R-HSA-9033478 "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin"
47. Reactome: R-HSA-9033491 "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin"
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// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
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