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Gene ontology
Version 2014-12-22
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Details for metallopeptidase activity
Gene ontology ID
GO:0008237
Definition
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions
Synonyms
1. metalloprotease activity
2. metalloproteinase activity
References
1. GOC: mah
2. http merops.sanger.ac.uk/about/glossary.htm#CATTYPE
3. Reactome: R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2"
4. Reactome: R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1"
5. Reactome: R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain"
6. Reactome: R-HSA-2022368 "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)"
7. Reactome: R-HSA-2022393 "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)"
8. Reactome: R-HSA-2022396 "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)"
9. Reactome: R-HSA-2022399 "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)"
10. Reactome: R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants"
11. Reactome: R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding"
12. Reactome: R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580 K2555) is cleaved to produce NEXT1"
13. Reactome: R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding"
14. Reactome: R-HSA-3928660 "ADAM10 cleaves EFNAs"
15. Reactome: R-HSA-5211340 "Anthrax LF cleaves target cell MAP2K1 (MEK1)"
16. Reactome: R-HSA-5211356 "Anthrax LF cleaves target cell MAP2K2 (MEK2)"
17. Reactome: R-HSA-5211387 "Anthrax LF cleaves target cell MAP2K7 (MEK7)"
18. Reactome: R-HSA-5211391 "Anthrax LF cleaves target cell MAP2K4 (MEK4)"
19. Reactome: R-HSA-5211400 "Anthrax LF cleaves target cell MAP2K3 (MEK3)"
20. Reactome: R-HSA-5211405 "Anthrax LF cleaves target cell MAP2K6 (MEK6)"
21. Reactome: R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)"
22. Reactome: R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3"
23. Reactome: R-HSA-9604264 "ADAM10 cleaves NOTCH4"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
metabolic process is a
nitrogen compound metabolic process is a
organonitrogen compound metabolic process is a
protein metabolic process is a
proteolysis is a
peptidase activity part of
peptidase activity, acting on L-amino acid peptides is a
metallopeptidase activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
aldoxime metabolic process is a
ammonia oxidation is a
ammonium ion metabolic process is a
betaine aldehyde metabolic process is a
nitrogen cycle metabolic process is a
organonitrogen compound metabolic process is a
alkaloid metabolic process is a
amine metabolic process is a
aminoglycan metabolic process is a
N',N'',N'''-triacetylfusarinine C metabolic process is a
nitrile metabolic process is a
primary amino compound metabolic process is a
protein metabolic process is a
amyloid precursor protein metabolic process is a
cytochrome metabolic process is a
cytokine metabolic process is a
insulin metabolic process is a
lipoprotein metabolic process is a
protein activation cascade is a
protein maturation is a
protein modification process is a
proteolysis is a
membrane protein proteolysis is a
peptidase activity part of
isopeptidase activity is a
oligopeptidase activity is a
peptidase activity, acting on D-amino acid peptides is a
peptidase activity, acting on L-amino acid peptides is a
aspartic-type peptidase activity is a
ATP-dependent peptidase activity is a
cysteine-type peptidase activity is a
endopeptidase activity is a
exopeptidase activity is a
glutamic-type peptidase activity is a
metallopeptidase activity is a
serine-type peptidase activity is a
threonine-type peptidase activity is a
self proteolysis is a
wybutosine metabolic process is a
reactive nitrogen species metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
aspartyl esterase activity is a
carboxylic ester hydrolase activity is a
DNA-3'-diphospho-5'-guanosine diphosphatase is a
enterochelin esterase activity is a
indole-3-acetyl-beta-1-D-glucose hydrolase activity is a
indole-3-acetyl-beta-4-D-glucose hydrolase activity is a
lipase activity is a
phosphoric ester hydrolase activity is a
sulfuric ester hydrolase activity is a
thiolester hydrolase activity is a
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity is a
2-oxoglutaryl-CoA thioesterase activity is a
3-isopropylbut-3-enoyl-CoA thioesterase activity is a
3-oxo-dodecanoyl-ACP hydrolase activity is a
3-oxo-myristoyl-ACP hydrolase activity is a
3-oxo-myristoyl-CoA hydrolase activity is a
3-oxo-palmitoyl-ACP hydrolase activity is a
3-oxoacyl-CoA hydrolase activity is a
acyl-[acyl-carrier-protein] hydrolase activity is a
CoA hydrolase activity is a
(S)-methylmalonyl-CoA hydrolase activity is a
1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity is a
3-hydroxyisobutyryl-CoA hydrolase activity is a
4-hydroxybenzoyl-CoA thioesterase activity is a
acetoacetyl-CoA hydrolase activity is a
acetyl-CoA hydrolase activity is a
acyl-CoA hydrolase activity is a
bile-acid-CoA hydrolase activity is a
choloyl-CoA hydrolase activity is a
formyl-CoA hydrolase activity is a
hydroxymethylglutaryl-CoA hydrolase activity is a
phenylacetyl-CoA hydrolase activity is a
succinyl-CoA hydrolase activity is a
glutathione thiolesterase activity is a
hydroxyacylglutathione hydrolase activity is a
myristoyl-CoA hydrolase activity is a
S-formylglutathione hydrolase activity is a
S-succinylglutathione hydrolase activity is a
[citrate-(pro-3S)-lyase] thiolesterase activity is a
versiconal hemiacetal acetate esterase activity is a
hydrolase activity, acting on ether bonds is a
hydrolase activity, acting on glycosyl bonds is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a