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Gene ontology
Version 2014-12-22
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Details for endopeptidase activity
Gene ontology ID
GO:0004175
Definition
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain
Synonyms
1. elastase activity
2. endoprotease activity
3. proteasome endopeptidase activity
4. proteinase
References
1. http merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE
2. MetaCyc RXN0-5195
3. Reactome: R-HSA-1168640 "Ubiquitinated IkB is degraded"
4. Reactome: R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha"
5. Reactome: R-HSA-1236935 "Proteasomal cleavage of substrate"
6. Reactome: R-HSA-1236970 "Proteasomal clevage of exogenous antigen"
7. Reactome: R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex"
8. Reactome: R-HSA-1433374 "Processing of SCF isoform 1"
9. Reactome: R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome"
10. Reactome: R-HSA-174058 "Degradation of multiubiquitinated Cdh1"
11. Reactome: R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins"
12. Reactome: R-HSA-174202 "Degradation of multiubiquitinated Securin"
13. Reactome: R-HSA-174203 "SCF-mediated degradation of Emi1"
14. Reactome: R-HSA-174255 "Degradation multiubiquitinated Cyclin A"
15. Reactome: R-HSA-180573 "Degradation of ubiquitinated CD4"
16. Reactome: R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G"
17. Reactome: R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome"
18. Reactome: R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2"
19. Reactome: R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain"
20. Reactome: R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex"
21. Reactome: R-HSA-211715 "Proteasome mediated degradation of PAK-2p34"
22. Reactome: R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome"
23. Reactome: R-HSA-2213200 "Release of endostatin-like peptides"
24. Reactome: R-HSA-264458 "Proteasome mediated degradation of COP1"
25. Reactome: R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex"
26. Reactome: R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome"
27. Reactome: R-HSA-3928656 "gamma-secretase cleaves EPHB2"
28. Reactome: R-HSA-450466 "AUF1:mRNA complex is destroyed"
29. Reactome: R-HSA-4608855 "PRICKLE1 is degraded by the proteasome"
30. Reactome: R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome"
31. Reactome: R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome"
32. Reactome: R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors"
33. Reactome: R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage"
34. Reactome: R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome"
35. Reactome: R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome"
36. Reactome: R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex"
37. Reactome: R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB"
38. Reactome: R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor"
39. Reactome: R-HSA-5610757 "GLI2 is degraded by the proteasome"
40. Reactome: R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP"
41. Reactome: R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH"
42. Reactome: R-HSA-5635854 "GLI2,3 are degraded by the proteasome"
43. Reactome: R-HSA-5635868 "ub-GLI is degraded by the proteasome"
44. Reactome: R-HSA-5658430 "NF1 is degraded by the proteasome"
45. Reactome: R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3"
46. Reactome: R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK"
47. Reactome: R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome"
48. Reactome: R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)"
49. Reactome: R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer"
50. Reactome: R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer"
51. Reactome: R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome"
52. Reactome: R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome"
53. Reactome: R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome"
54. Reactome: R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A"
55. Reactome: R-HSA-74730 "Insulin degradation"
56. Reactome: R-HSA-75825 "Proteasome mediated degradation of Cyclin D1"
57. Reactome: R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin"
58. Reactome: R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN"
59. Reactome: R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53"
60. Reactome: R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7"
61. Reactome: R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7"
62. Reactome: R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome"
63. Reactome: R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome"
64. Reactome: R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin"
65. Reactome: R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2"
66. Reactome: R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome"
67. Reactome: R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH"
68. Reactome: R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2"
69. Reactome: R-HSA-9008475 "Proteasome degrades polyubiquitinated RUNX2"
70. Reactome: R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2"
71. Reactome: R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)"
72. Reactome: R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1"
73. Reactome: R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4"
74. Reactome: R-HSA-983150 "Proteasomal cleavage of substrate"
75. Reactome: R-HSA-983158 "Trimming of peptides in ER"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
metabolic process is a
nitrogen compound metabolic process is a
organonitrogen compound metabolic process is a
protein metabolic process is a
proteolysis is a
peptidase activity part of
peptidase activity, acting on L-amino acid peptides is a
endopeptidase activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
aldoxime metabolic process is a
ammonia oxidation is a
ammonium ion metabolic process is a
betaine aldehyde metabolic process is a
nitrogen cycle metabolic process is a
organonitrogen compound metabolic process is a
alkaloid metabolic process is a
amine metabolic process is a
aminoglycan metabolic process is a
N',N'',N'''-triacetylfusarinine C metabolic process is a
nitrile metabolic process is a
primary amino compound metabolic process is a
protein metabolic process is a
amyloid precursor protein metabolic process is a
cytochrome metabolic process is a
cytokine metabolic process is a
insulin metabolic process is a
lipoprotein metabolic process is a
protein activation cascade is a
protein maturation is a
protein modification process is a
proteolysis is a
membrane protein proteolysis is a
peptidase activity part of
isopeptidase activity is a
oligopeptidase activity is a
peptidase activity, acting on D-amino acid peptides is a
peptidase activity, acting on L-amino acid peptides is a
aspartic-type peptidase activity is a
ATP-dependent peptidase activity is a
cysteine-type peptidase activity is a
endopeptidase activity is a
exopeptidase activity is a
glutamic-type peptidase activity is a
metallopeptidase activity is a
serine-type peptidase activity is a
threonine-type peptidase activity is a
self proteolysis is a
wybutosine metabolic process is a
reactive nitrogen species metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
beta-alanyl-dopamine hydrolase activity is a
beta-alanyl-histamine hydrolase activity is a
coenzyme F390-A hydrolase activity is a
coenzyme F390-G hydrolase activity is a
deacetylase activity is a
deaminase activity is a
hydrolase activity, acting on acid anhydrides is a
hydrolase activity, acting on acid carbon-carbon bonds is a
hydrolase activity, acting on acid carbon-phosphorus bonds is a
hydrolase activity, acting on acid halide bonds is a
hydrolase activity, acting on acid phosphorus-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-nitrogen bonds is a
hydrolase activity, acting on acid sulfur-sulfur bonds is a
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is a
hydrolase activity, acting on carbon-sulfur bonds is a
hydrolase activity, acting on ester bonds is a
aspartyl esterase activity is a
carboxylic ester hydrolase activity is a
DNA-3'-diphospho-5'-guanosine diphosphatase is a
enterochelin esterase activity is a
indole-3-acetyl-beta-1-D-glucose hydrolase activity is a
indole-3-acetyl-beta-4-D-glucose hydrolase activity is a
lipase activity is a
phosphoric ester hydrolase activity is a
sulfuric ester hydrolase activity is a
thiolester hydrolase activity is a
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity is a
2-oxoglutaryl-CoA thioesterase activity is a
3-isopropylbut-3-enoyl-CoA thioesterase activity is a
3-oxo-dodecanoyl-ACP hydrolase activity is a
3-oxo-myristoyl-ACP hydrolase activity is a
3-oxo-myristoyl-CoA hydrolase activity is a
3-oxo-palmitoyl-ACP hydrolase activity is a
3-oxoacyl-CoA hydrolase activity is a
acyl-[acyl-carrier-protein] hydrolase activity is a
CoA hydrolase activity is a
(S)-methylmalonyl-CoA hydrolase activity is a
1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity is a
3-hydroxyisobutyryl-CoA hydrolase activity is a
4-hydroxybenzoyl-CoA thioesterase activity is a
acetoacetyl-CoA hydrolase activity is a
acetyl-CoA hydrolase activity is a
acyl-CoA hydrolase activity is a
bile-acid-CoA hydrolase activity is a
choloyl-CoA hydrolase activity is a
formyl-CoA hydrolase activity is a
hydroxymethylglutaryl-CoA hydrolase activity is a
phenylacetyl-CoA hydrolase activity is a
succinyl-CoA hydrolase activity is a
glutathione thiolesterase activity is a
hydroxyacylglutathione hydrolase activity is a
myristoyl-CoA hydrolase activity is a
S-formylglutathione hydrolase activity is a
S-succinylglutathione hydrolase activity is a
[citrate-(pro-3S)-lyase] thiolesterase activity is a
versiconal hemiacetal acetate esterase activity is a
hydrolase activity, acting on ether bonds is a
hydrolase activity, acting on glycosyl bonds is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a