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Version 2014-12-22
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Details for polypeptide N-acetylgalactosaminyltransferase activity
2.4.1.41
Gene ontology ID
GO:0004653
Definition
Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis
Synonyms
1. glycoprotein acetylgalactosaminyltransferase activity
2. polypeptide-N-acetylgalactosamine transferase activity
3. protein-UDP acetylgalactosaminyltransferase activity
4. UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
5. UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity
6. UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity
7. UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity
8. UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity
9. UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity
10. UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity
11. UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity
12. UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity
13. UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity
14. UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity
15. uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity
References
1. EC 2.4.1.41
2. ISBN 0879695595
3. MetaCyc 2.4.1.41-RXN
4. Reactome: R-HSA-5096532 "Defective GALNT12 does not transfer GalNAc to mucins"
5. Reactome: R-HSA-5096537 "Defective GALNT3 does not transfer GalNAc to mucins"
6. Reactome: R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23"
7. Reactome: R-HSA-913675 "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens"
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