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Gene ontology
Version 2014-12-22
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Details for CAAX-box protein maturation
Gene ontology ID
GO:0080120
Definition
A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase
Synonyms
1. CAAX-box protein processing
2. farnesylated protein maturation
References
1. PMID 12039957
2. PMID 17114793
3. PMID 18641086
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is a part of the parent element
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Condensed Tree View
Gene ontology
biological_process is a
cellular process is a
cellular metabolic process is a
cellular macromolecule metabolic process is a
cellular protein metabolic process is a
CAAX-box protein maturation is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
actin filament-based process is a
cell activation is a
cell adhesion molecule production is a
cell aggregation is a
cell communication is a
cell cycle is a
cell death is a
cell division is a
cell growth is a
cell killing is a
cell population proliferation is a
cell recognition is a
cell wall organization or biogenesis is a
cell-cell fusion is a
cellular component organization or biogenesis is a
cellular detoxification is a
cellular developmental process is a
cellular localization is a
cellular metabolic process is a
bioluminescence is a
cellular alcohol metabolic process is a
cellular aldehyde metabolic process is a
cellular alkane metabolic process is a
cellular alkene metabolic process is a
cellular alkyne metabolic process is a
cellular aromatic compound metabolic process is a
cellular biosynthetic process is a
cellular carbohydrate metabolic process is a
cellular catabolic process is a
cellular ketone body metabolic process is a
cellular ketone metabolic process is a
cellular lipid metabolic process is a
cellular macromolecule metabolic process is a
cellular protein metabolic process is a
CAAX-box protein maturation is a
cellular protein modification process is a
ferredoxin metabolic process is a
mitochondrial protein processing is a
Notch receptor processing is a
prosthetic group metabolic process part of
protein repair is a
rhodopsin metabolic process is a
signal peptide processing is a
vacuolar protein processing is a
glycoprotein metabolic process is a
hemoglobin metabolic process is a
macromolecule methylation is a
poly-gamma-glutamate metabolic process is a
receptor metabolic process is a
cellular metabolic compound salvage is a
cellular modified amino acid metabolic process is a
cellular nitrogen compound metabolic process is a
cellular organohalogen metabolic process is a
chemosynthesis is a
cofactor metabolic process is a
drug metabolic process is a
generation of precursor metabolites and energy is a
heterocycle metabolic process is a
hydroperoxide metabolic process is a
metabolite repair is a
mucilage metabolic process is a
one-carbon metabolic process is a
organic acid metabolic process is a
organometal metabolic process is a
phosphorus metabolic process is a
photosynthesis is a
prenylation is a
reactive oxygen species metabolic process is a
selenium compound metabolic process is a
sulfur compound metabolic process is a
toxin metabolic process is a
xenobiotic metabolic process is a
cellular pigmentation is a
cellular process involved in reproduction in multicellular organism is a
cellular response to stimulus is a
chromosome segregation is a
cytolysis is a
DNA clamp unloading is a
ensheathment of neurons is a
establishment or maintenance of cell polarity is a
establishment or maintenance of cell type involved in phenotypic switching is a
export from cell is a
intercellular transport is a
intermediate filament-based process is a
light absorption is a
localization of cell is a
membrane docking is a
microtubule organizing center localization is a
microtubule-based process is a
movement of cell or subcellular component is a
multi-organism cellular process is a
phenotypic switching is a
plasmid maintenance is a
process utilizing autophagic mechanism is a
protein folding is a
protein unfolding is a
RNA folding is a
signaling receptor ligand precursor processing is a
stomatal movement is a
syncytium formation is a
transmembrane transport is a
transposition is a
vacuolar transport is a
vesicle-mediated transport is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
Atg8 ligase activity is a
CDP-alcohol phosphotransferase activity is a
glucanosyltransferase activity is a
Kdo transferase activity is a
mannosylphosphate transferase activity is a
molybdopterin molybdotransferase activity is a
transferase activity, transferring acyl groups is a
transferase activity, transferring acyl groups other than amino-acyl groups is a
(Z)-3-hexen-1-ol acetyltransferase activity is a
13-hydroxylupinine O-tigloyltransferase activity is a
2,3-diaminopropionate N-oxalyltransferase activity is a
2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity is a
2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity is a
2-alpha-hydroxytaxane 2-O-benzoyltransferase activity is a
2-ketobutyrate formate-lyase activity is a
2-methylhexanoyl-CoA C-acetyltransferase activity is a
2-phenylethanol acetyltransferase activity is a
3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity is a
3-hydroxybutyryl-CoA thiolase activity is a
3-keto-5-aminohexanoate cleavage activity is a
3-ketopimelyl-CoA thiolase activity is a
3-oxo-arachidoyl-CoA synthase activity is a
3-oxo-cerotoyl-CoA synthase activity is a
3-oxo-lignoceronyl-CoA synthase activity is a
3-oxoadipyl-CoA thiolase activity is a
4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity is a
4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity is a
4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity is a
4-coumaroylhexanoylmethane synthase activity is a
4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity is a
5-pentadecatrienylresorcinol synthase activity is a
6'-deoxychalcone synthase activity is a
6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity is a
6-methylsalicylic acid synthase activity is a
8-amino-7-oxononanoate synthase activity is a
acetoacetyl-ACP synthase activity is a
acetyl-coenzyme A:acetyl alcohol acetyltransferase activity is a
acetyltransferase activity is a
acridone synthase activity is a
acrylate:acyl-coA CoA transferase activity is a
acyl coenzyme A: isopenicillin N acyltransferase activity is a
acyl-phosphate glycerol-3-phosphate acyltransferase activity is a
agmatine N4-coumaroyltransferase activity is a
alcohol O-cinnamoyltransferase activity is a
anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity is a
anthocyanin 5-aromatic acyltransferase activity is a
anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity is a
anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity is a
anthocyanin 6''-O-malonyltransferase activity is a
anthranilate N-benzoyltransferase activity is a
arachidoyl-CoA:1-dodecanol O-acyltransferase activity is a
benzoyl acetate-CoA thiolase activity is a
beta-glucogallin O-galloyltransferase activity is a
beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity is a
beta-ketoacyl-acyl-carrier-protein synthase II activity is a
beta-ketoacyl-acyl-carrier-protein synthase III activity is a
biphenyl synthase activity is a
bisdemethoxycurcumin synthase activity is a
butanoyltransferase activity is a
butyryl-CoA 2-C-propionyltransferase activity is a
C-acyltransferase activity is a
caffeoyl-CoA: alcohol caffeoyl transferase activity is a
caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity is a
caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity is a
caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity is a
caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity is a
chalcone synthase activity is a
CO-methylating acetyl-CoA synthase activity is a
curcumin synthase activity is a
cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity is a
cyanidin 3-O-glucoside 6''-O-malonyltransferase activity is a
cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity is a
cyanidin 3-O-glucoside-p-coumaroyltransferase activity is a
cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity is a
cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity is a
cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity is a
cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity is a
cysteine-S-conjugate N-malonyl transferase activity is a
decanoyltransferase activity is a
delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity is a
delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity is a
demethoxycurcumin synthase is a
demethoxycurcumin synthase activity is a
demethoxycurcumin synthase activity from feruloylacetyl-CoA is a
diacylglycerol transacylase activity is a
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity is a
erythronolide synthase activity is a
fatty acid synthase activity is a
fatty-acyl-[acp] elongase/decarboxylase activity is a
flavonol-3-O-triglucoside O-coumaroyltransferase activity is a
gamma-linolenate elongase activity is a
glutamine N-phenylacetyltransferase activity is a
glycero-3-phosphocholine acyltransferase activity is a
glycerophospholipid acyltransferase (CoA-dependent) activity is a
glycerophospholipid arachidonoyl-transferase (CoA-independent) activity is a
glycine N-benzoyltransferase activity is a
glycine N-choloyltransferase activity is a
heptadecanoyl-[acp] elongase/decarboxylase activity is a
hexanoyltransferase activity is a
hydroxycinnamoyltransferase activity is a
icosanoyl-CoA synthase activity is a
isocitrate O-dihydroxycinnamoyltransferase activity is a
keto acid formate lyase activity is a
lauroyltransferase activity is a
lecithin:11-cis retinol acyltransferase activity is a
lipoyl(octanoyl) transferase activity is a
lipoyltransferase activity is a
lovastatin nonaketide synthase activity is a
lysophospholipid acyltransferase activity is a
malonyl-malonyl acyl carrier protein-condensing enzyme activity is a
malonyltransferase activity is a
methione N-acyltransferase activity is a
mycocerosate synthase activity is a
mycothiol synthase activity is a
myristoyltransferase activity is a
N(6)-L-threonylcarbamoyladenine synthase activity is a
N-acyltransferase activity is a
naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity is a
naringenin-chalcone synthase activity is a
norsolorinate anthrone synthase activity is a
O-acyltransferase activity is a
octanoyltransferase activity is a
omega-hydroxypalmitate O-sinapoyl transferase activity is a
ornithine N-benzoyltransferase activity is a
ornithine N-delta-acetyltransferase activity is a
p-coumaroyltriacetic acid lactone synthase activity is a
p-coumaroyltriacetic acid synthase activity is a
palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity is a
palmitoleoyltransferase activity is a
palmitoyl-[acp] elongase/decarboxylase activity is a
palmitoyltransferase activity is a
phenylacetyl-coenzyme A:glycine N-acyltransferase activity is a
phenylpropanoyltransferase activity is a
phloroisovalerophenone synthase activity is a
phosphate butyryltransferase activity is a
phosphate:acyl-[acyl carrier protein] acyltransferase activity is a
phosphinothricin N-acetyltransferase activity is a
pinosylvin synthase activity is a
piperidine N-piperoyltransferase activity is a
plasmalogen synthase activity is a
propionyl-CoA C2-trimethyltridecanoyltransferase activity is a
pyruvyltransferase activity is a
rosmarinate synthase activity is a
S-acyltransferase activity is a
sinapoyltransferase activity is a
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity is a
sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity is a
stearoyl-[acp] elongase/decarboxylase activity is a
succinyltransferase activity is a
tetrahydroxybenzophenone synthase activity is a
tetraketide alpha-pyrone synthase activity is a
trehalose O-mycolyltransferase activity is a
trihydroxybenzophenone synthase activity is a
trihydroxystilbene synthase activity is a
tyramine N-feruloyltransferase activity is a
UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity is a
very-long-chain 3-ketoacyl-CoA synthase activity is a
vinorine synthase activity is a
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer is a
transferase activity, transferring aldehyde or ketonic groups is a
transferase activity, transferring alkyl or aryl (other than methyl) groups is a
transferase activity, transferring glycosyl groups is a
transferase activity, transferring nitrogenous groups is a
transferase activity, transferring one-carbon groups is a
transferase activity, transferring phosphorus-containing groups is a
transferase activity, transferring selenium-containing groups is a
transferase activity, transferring sulfur-containing groups is a
UDP-L-rhamnose synthase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a