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Gene ontology
Version 2014-12-22
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Details for catechol O-methyltransferase activity
2.1.1.6
Gene ontology ID
GO:0016206
Definition
Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol
Synonyms
1. catechol methyltransferase activity
2. catecholamine O-methyltransferase activity
3. COMT I
4. COMT II
5. MB-COMT (membrane-bound form of catechol-O-methyltransferase)
6. S-adenosyl-L-methionine:catechol O-methyltransferase activity
7. S-COMT (soluble form of catechol-O-methyltransferase)
References
1. EC 2.1.1.6
2. MetaCyc CATECHOL-O-METHYLTRANSFERASE-RXN
3. Reactome: R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ"
4. Reactome: R-HSA-8955010 "LRTOMT transfers methyl group from AdoMet to DA, forming 3MT"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
molecular_function is a
catalytic activity is a
transferase activity is a
transferase activity, transferring one-carbon groups is a
methyltransferase activity is a
O-methyltransferase activity is a
catechol O-methyltransferase activity is a
Tree view
Gene ontology
biological_process is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
Atg8 ligase activity is a
CDP-alcohol phosphotransferase activity is a
glucanosyltransferase activity is a
Kdo transferase activity is a
mannosylphosphate transferase activity is a
molybdopterin molybdotransferase activity is a
transferase activity, transferring acyl groups is a
transferase activity, transferring aldehyde or ketonic groups is a
transferase activity, transferring alkyl or aryl (other than methyl) groups is a
transferase activity, transferring glycosyl groups is a
transferase activity, transferring nitrogenous groups is a
transferase activity, transferring one-carbon groups is a
carboxyl- or carbamoyltransferase activity is a
hydroxymethyl-, formyl- and related transferase activity is a
methyltransferase activity is a
(R)-reticuline 7-O-methyltransferase activity is a
(S)-reticuline 7-O-methyltransferase activity is a
1-hydroxy-6-methoxypyrene methyltransferase activity is a
1-hydroxypyrene methyltransferase activity is a
1-phenanthrol methyltransferase activity is a
12-demethyl-elloramycin C12a O-methyltransferase activity is a
2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity is a
2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity is a
2-polyprenyl-6-hydroxyphenol methylase activity is a
3',4',5'-trimethylmyricetin 3-O-methyltransferase activity is a
3',4',5'-trimethylmyricetin 7-O-methyltransferase activity is a
3'-O-methyltricetin O methyl transferase activity is a
3,5-dihydroxyanisole O-methyltransferase activity is a
3,5-dimethoxyphenol O-methyltransferase activity is a
3-aminomethylindole N-methyltransferase activity is a
3-methoxy-5-hydroxytoluene O-methyltransferase activity is a
3-methylquercetin 3'-O-methyltransferase activity is a
4,5-dihydroxybenzo(a)pyrene methyltransferase activity is a
4-hydroxytryptamine 4-phosphate methyltransferase activity is a
5,10-methylenetetrahydrofolate-dependent methyltransferase activity is a
5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity is a
5-methyl-phenazine-1-carboxylate N-methyltransferase activity is a
5-methyltetrahydrofolate-dependent methyltransferase activity is a
5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity is a
5-n-alk(en)ylresorcinol O-methyltransferase activity is a
6a-hydroxymaackiain-3-O-methyltransferase activity is a
7,8,4'-trihydroxyflavone methyltransferase activity is a
7-methylmyricetin 4'-O-methyltransferase activity is a
8-demethylnovobiocic acid C8-methyltransferase activity is a
adrenaline O-methyltransferase activity is a
aminomethyltransferase activity is a
apigenin 7-O-methyltransferase activity is a
bixin methyltransferase activity is a
C-methyltransferase activity is a
C4-demethylase activity is a
C4-methyltransferase activity is a
caffeoylglucose 3-O-methyltransferase activity is a
cirsimaritin 4'-O-methyltransferase activity is a
cobalt-factor II C20-methyltransferase activity is a
cobalt-precorrin-3 C17-methyltransferase activity is a
cobalt-precorrin-5B C1-methyltransferase activity is a
cobalt-precorrin-6B C5-methyltransferase activity is a
cobalt-precorrin-7 C15-methyltransferase activity is a
corydaline synthase activity is a
daphnetin-8-O-methyltransferase activity is a
demethylmenaquinone methyltransferase activity is a
demethylrebeccamycin--D-glucose O-methyltransferase activity is a
dimethyl selenide methyltransferase activity is a
dimethylamine methyltransferase activity is a
dimethylarsinite methyltransferase activity is a
dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity is a
dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity is a
dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity is a
eriodictyol 3'-O-methyltransferase activity is a
eriodictyol 4'-O-methyltransferase activity is a
erythromycin C 3''-o-methyltransferase activity is a
erythromycin D 3''-o-methyltransferase activity is a
flavanone 4'-O-methyltransferase activity is a
genkwanin 4'-O-methyltransferase activity is a
gibberellin A20 carboxyl methyltransferase activity is a
gibberellin A34 carboxyl methyltransferase activity is a
gibberellin A4 carboxyl methyltransferase activity is a
gibberellin A9 carboxyl methyltransferase activity is a
gossypetin 8-methyl ester 3'-O-methyltransferase activity is a
hydrogen selenide methyltransferase activity is a
hydroxyneurosporene-O-methyltransferase activity is a
indole acetic acid carboxyl methyltransferase activity is a
indole-3-acetate carboxyl methyltransferase activity is a
isorhamnetin 3-O-methyltransferase activity is a
isoscopoletin-O-methyltransferase activity is a
juvenile hormone acid methyltransferase activity is a
kaempferide 3-O-methyltransferase activity is a
kaempferide 7-O-methyltransferase activity is a
kaempferol 3-O-methyltransferase activity is a
L-dopa O-methyltransferase activity is a
ladanein 6-O-methyltransferase activity is a
laricitrin 4'-O-methyltransferase activity is a
malonyl-CoA methyltransferase activity is a
methaneselenol methyltransferase activity is a
methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity is a
methanol-specific methylcobalamin:coenzyme M methyltransferase activity is a
methyl jasmonate methylesterase activity is a
methylamine-specific methylcobalamin:coenzyme M methyltransferase activity is a
methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity is a
methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity is a
methylthiol:coenzyme M methyltransferase activity is a
monomethylamine methyltransferase activity is a
mycinamicin VI 2''-O-methyltransferase activity is a
myricetin 7-O-methyltransferase activity is a
N-methyl-3-aminomethylindole N-methyltransferase activity is a
N-methyltransferase activity is a
naringenin 7-O-methyltransferase activity is a
norbixin methyltransferase activity is a
O-methyltransferase activity is a
(iso)eugenol O-methyltransferase activity is a
2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity is a
2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity is a
2-polyprenyl-6-hydroxyphenol O-methyltransferase activity is a
3-demethylubiquinol-n 3-O-methyltransferase activity is a
acetylserotonin O-methyltransferase activity is a
caffeate O-methyltransferase activity is a
caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity is a
caffeoyl-CoA O-methyltransferase activity is a
carboxyl-O-methyltransferase activity is a
catechol O-methyltransferase activity is a
demethylsterigmatocystin 6-O-methyltransferase activity is a
farnesoic acid O-methyltransferase activity is a
isoflavone 7-O-methyltransferase activity is a
isoliquiritigenin 2'-O-methyltransferase activity is a
kaempferol 4'-O-methyltransferase activity is a
laricitrin 5'-O-methyltransferase activity is a
magnesium protoporphyrin IX methyltransferase activity is a
myricetin 3'-O-methyltransferase activity is a
S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity is a
sterigmatocystin 7-O-methyltransferase activity is a
tocopherol O-methyltransferase activity is a
tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity is a
trihydroxyferuloyl spermidine O-methyltransferase activity is a
trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity is a
vitexin 2''-O-rhamnoside 7-O-methyltransferase activity is a
orcinol O-methyltransferase activity is a
P-methyltransferase activity is a
paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity is a
patuletin 3'-O-methyltransferase activity is a
phloroglucinol O-methyltransferase activity is a
precorrin-6A synthase (deacetylating) activity is a
protein-(glutamine-N5) methyltransferase activity is a
quercetin 3'-O-methyltransferase activity is a
quercetin 7-O-methyltransferase activity is a
resveratrol 3,5-O-dimethyltransferase activity is a
rhamnetin 3'-O-methyltransferase activity is a
rhamnetin 3-O-methyltransferase activity is a
rhamnetin 4'-O-methyltransferase activity is a
S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity is a
S-adenosyl-L-methionine:eugenol-O-methyltransferase activity is a
S-adenosylmethionine-dependent methyltransferase activity is a
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity is a
(RS)-norcoclaurine 6-O-methyltransferase activity is a
(S)-coclaurine-N-methyltransferase activity is a
(S)-scoulerine 9-O-methyltransferase activity is a
(S)-tetrahydroprotoberberine N-methyltransferase activity is a
10-hydroxydihydrosanguinarine 10-O-methyltransferase activity is a
11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity is a
12-hydroxydihydrochelirubine 12-O-methyltransferase activity is a
16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity is a
2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity is a
2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity is a
24-methylenesterol C-methyltransferase activity is a
3'-demethylstaurosporine O-methyltransferase activity is a
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity is a
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity is a
3,7-dimethylquercitin 4'-O-methyltransferase activity is a
3-hydroxyanthranilate 4-C-methyltransferase activity is a
3-methylquercitin 7-O-methyltransferase activity is a
5-hydroxyfuranocoumarin 5-O-methyltransferase activity is a
6-hydroxymellein O-methyltransferase activity is a
6-O-methylnorlaudanosoline 5'-O-methyltransferase activity is a
8-hydroxyfuranocoumarin 8-O-methyltransferase activity is a
8-hydroxyquercitin 8-O-methyltransferase activity is a
amine N-methyltransferase activity is a
anthranilate N-methyltransferase activity is a
apigenin 4'-O-methyltransferase activity is a
arsenite methyltransferase activity is a
carnosine N-methyltransferase activity is a
chlorophenol O-methyltransferase activity is a
columbamine O-methyltransferase activity is a
cycloartenol 24-C-methyltransferase activity is a
cyclopropane-fatty-acyl-phospholipid synthase activity is a
demethylmacrocin O-methyltransferase activity is a
dimethylhistidine N-methyltransferase activity is a
diphthine synthase activity is a
fatty acid O-methyltransferase activity is a
glucuronoxylan 4-O-methyltransferase activity is a
guanidinoacetate N-methyltransferase activity is a
histidine N-methyltransferase activity is a
indolepyruvate C-methyltransferase activity is a
inositol 1-methyltransferase activity is a
inositol 3-methyltransferase activity is a
inositol 4-methyltransferase activity is a
iodophenol O-methyltransferase activity is a
isobutyraldoxime O-methyltransferase activity is a
isoflavone 4'-O-methyltransferase activity is a
isoorientin 3'-O-methyltransferase activity is a
jasmonate O-methyltransferase activity is a
licodione 2'-O-methyltransferase activity is a
lipid A phosphate methyltransferase activity is a
loganate O-methyltransferase activity is a
luteolin O-methyltransferase activity is a
macrocin O-methyltransferase activity is a
methionine S-methyltransferase activity is a
methylarsonite methyltransferase activity is a
methylene-fatty-acyl-phospholipid synthase activity is a
methylhistidine N-methyltransferase activity is a
methylquercetagetin 6-O-methyltransferase activity is a
N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity is a
O-demethylpuromycin O-methyltransferase activity is a
phenol O-methyltransferase activity is a
polysaccharide O-methyltransferase activity is a
precorrin-2 C20-methyltransferase activity is a
precorrin-3B C17-methyltransferase activity is a
precorrin-4 C11-methyltransferase activity is a
precorrin-6Y C5,15-methyltransferase (decarboxylating) activity is a
putrescine N-methyltransferase activity is a
pyridine N-methyltransferase activity is a
quercetin 3-O-methyltransferase activity is a
S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity is a
S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity is a
S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity is a
S-adenosylmethionine-homocysteine S-methyltransferase activity is a
tellurite methyltransferase activity is a
tetrahydrocolumbamine 2-O-methyltransferase activity is a
thioether S-methyltransferase activity is a
thiol S-methyltransferase activity is a
thiopurine S-methyltransferase activity is a
trans-aconitate 2-methyltransferase activity is a
trans-aconitate 3-methyltransferase activity is a
tryptophan 2-C-methyltransferase activity is a
tyramine N-methyltransferase activity is a
[cytochrome c]-methionine S-methyltransferase activity is a
[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity is a
S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity is a
S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity is a
S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity is a
S-methyltransferase activity is a
scutellarein 7-methyl ether 4'-O-methyltransferase activity is a
scutellarein 7-methyl ether 6-O-methyltransferase activity is a
Se-methyltransferase activity is a
selenol Se-methyltransferase activity is a
sterol 24C methyltransferase activity is a
syringetin 3-O-methyltransferase activity is a
syringetin 7-O-methyltransferase activity is a
tetracenomycin B3 8-O-methyl transferase activity is a
theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity is a
thiocyanate methyltransferase activity is a
TRIBOA-glucoside methyltransferase activity is a
tricaffeoyl spermidine O-methyltransferase activity is a
tricetin O-methytransferase activity is a
trimethylamine methyltransferase activity is a
[methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase activity is a
transferase activity, transferring phosphorus-containing groups is a
transferase activity, transferring selenium-containing groups is a
transferase activity, transferring sulfur-containing groups is a
UDP-L-rhamnose synthase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a