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Version 2014-12-22
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Details for apoptotic signaling pathway
Gene ontology ID
GO:0097190
Definition
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered
Comment
This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
Synonyms
1. apoptotic signalling pathway
2. induction of apoptosis by extracellular signals
References
1. GOC: mtg apoptosis
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