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Gene ontology
Version 2014-12-22
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Details for glyoxalase III activity
4.2.1.130
Gene ontology ID
GO:0019172
Definition
Catalysis of the reaction: methylglyoxal + H2O = D-lactate
Comment
Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase).
Synonyms
1. (R)-lactate hydro-lyase
2. D-lactate dehydratase
3. glutathione-independent glyoxalase activity
References
1. EC 4.2.1.130
2. GOC: mcc
3. http www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130
4. MetaCyc GLYOXIII-RXN
5. PMID 21696459
6. PMID 7848303
7. RHEA: 27754
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
cellular process is a
cellular metabolic process is a
cellular aldehyde metabolic process is a
aldehyde catabolic process is a
methylglyoxal catabolic process is a
methylglyoxal catabolic process to lactate is a
glyoxalase III activity part of
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
actin filament-based process is a
cell activation is a
cell adhesion molecule production is a
cell aggregation is a
cell communication is a
cell cycle is a
cell death is a
cell division is a
cell growth is a
cell killing is a
cell population proliferation is a
cell recognition is a
cell wall organization or biogenesis is a
cell-cell fusion is a
cellular component organization or biogenesis is a
cellular detoxification is a
cellular developmental process is a
cellular localization is a
cellular metabolic process is a
bioluminescence is a
cellular alcohol metabolic process is a
cellular aldehyde metabolic process is a
(-)-secologanin metabolic process is a
6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde is a
acetaldehyde metabolic process is a
aldehyde biosynthetic process is a
aldehyde catabolic process is a
chanoclavine-I aldehyde catabolic process is a
glyceraldehyde-3-phosphate catabolic process is a
glyoxal catabolic process is a
glyoxylate catabolic process is a
methylglyoxal catabolic process is a
methylglyoxal catabolic process to lactate is a
D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde is a
glyoxalase III activity part of
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione is a
pyridoxal phosphate catabolic process is a
vanillin catabolic process is a
chanoclavine-I aldehyde metabolic process is a
formaldehyde metabolic process is a
furaldehyde metabolic process is a
glyceraldehyde-3-phosphate metabolic process is a
glyoxal metabolic process is a
glyoxylate metabolic process is a
hexadecanal metabolic process is a
methylglyoxal metabolic process is a
pyridoxal metabolic process is a
pyridoxal phosphate metabolic process is a
retinal metabolic process is a
vanillin metabolic process is a
cellular alkane metabolic process is a
cellular alkene metabolic process is a
cellular alkyne metabolic process is a
cellular aromatic compound metabolic process is a
cellular biosynthetic process is a
cellular carbohydrate metabolic process is a
cellular catabolic process is a
cellular ketone body metabolic process is a
cellular ketone metabolic process is a
cellular lipid metabolic process is a
cellular macromolecule metabolic process is a
cellular metabolic compound salvage is a
cellular modified amino acid metabolic process is a
cellular nitrogen compound metabolic process is a
cellular organohalogen metabolic process is a
chemosynthesis is a
cofactor metabolic process is a
drug metabolic process is a
generation of precursor metabolites and energy is a
heterocycle metabolic process is a
hydroperoxide metabolic process is a
metabolite repair is a
mucilage metabolic process is a
one-carbon metabolic process is a
organic acid metabolic process is a
organometal metabolic process is a
phosphorus metabolic process is a
photosynthesis is a
prenylation is a
reactive oxygen species metabolic process is a
selenium compound metabolic process is a
sulfur compound metabolic process is a
toxin metabolic process is a
xenobiotic metabolic process is a
cellular pigmentation is a
cellular process involved in reproduction in multicellular organism is a
cellular response to stimulus is a
chromosome segregation is a
cytolysis is a
DNA clamp unloading is a
ensheathment of neurons is a
establishment or maintenance of cell polarity is a
establishment or maintenance of cell type involved in phenotypic switching is a
export from cell is a
intercellular transport is a
intermediate filament-based process is a
light absorption is a
localization of cell is a
membrane docking is a
microtubule organizing center localization is a
microtubule-based process is a
movement of cell or subcellular component is a
multi-organism cellular process is a
phenotypic switching is a
plasmid maintenance is a
process utilizing autophagic mechanism is a
protein folding is a
protein unfolding is a
RNA folding is a
signaling receptor ligand precursor processing is a
stomatal movement is a
syncytium formation is a
transmembrane transport is a
transposition is a
vacuolar transport is a
vesicle-mediated transport is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a
binding is a
catalytic activity is a
catalytic activity, acting on a protein is a
catalytic activity, acting on DNA is a
catalytic activity, acting on RNA is a
cyclase activity is a
hydrolase activity is a
isomerase activity is a
ligase activity is a
lyase activity is a
2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity is a
alkylmercury lyase activity is a
carbon phosphorus lyase activity is a
carbon-carbon lyase activity is a
carbon-halide lyase activity is a
carbon-nitrogen lyase activity is a
carbon-oxygen lyase activity is a
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity is a
carbon-oxygen lyase activity, acting on phosphates is a
carbon-oxygen lyase activity, acting on polysaccharides is a
carboxymethyloxysuccinate lyase activity is a
hydro-lyase activity is a
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity is a
(R)-2-methylmalate dehydratase activity is a
(S)-2-methylmalate dehydratase activity is a
(S)-norcoclaurine synthase activity is a
1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity is a
1,5-anhydro-D-fructose dehydratase activity is a
14betaH-scalarane-17alpha-19-diol synthase activity is a
16-alpha-hydroxyprogesterone dehydratase activity is a
17(E)-cheilanthenediol synthase activity is a
2,4,4-trimethylpent-2-enoyl-CoA hydratase activity is a
2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity is a
2-dehydro-3-deoxy-L-arabinonate dehydratase activity is a
2-hydroxydec-2,4-diene-1,10-dioate hydratase activity is a
2-hydroxyeriodictyol 6C-glucoside dehydratase activity is a
2-hydroxyglutaryl-CoA dehydratase activity is a
2-hydroxyhexa-2,4-dienoate hydratase activity is a
2-hydroxyisobutyrate dehydratase activity is a
2-hydroxyisoflavanone dehydratase activity is a
2-hydroxynaringenin-6C-glucoside dehydratase activity is a
2-keto-3-deoxygalactonate aldolase activity is a
2-methylcitrate dehydratase activity is a
2-methylhex-2-enoyl-CoA hydratase activity is a
2-methylisocitrate dehydratase activity is a
2-oxo-hept-3-ene-1,7-dioate hydratase activity is a
2-oxopent-4-enoate hydratase activity is a
3-cyanoalanine hydratase activity is a
3-dehydroquinate dehydratase activity is a
3-dehydroshikimate dehydratase activity is a
3-hydroxy-arachidoyl-CoA dehydratase activity is a
3-hydroxy-behenoyl-CoA dehydratase activity is a
3-hydroxy-cerotoyl-CoA dehydratase activity is a
3-hydroxy-lignoceroyl-CoA dehydratase activity is a
3-hydroxyacyl-CoA dehydratase activity is a
3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity is a
3-hydroxybutyryl-CoA dehydratase activity is a
3-hydroxypropionyl-CoA dehydratase activity is a
3-isopropylmalate dehydratase activity is a
3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity is a
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity is a
3R-hydroxyacyl-CoA dehydratase activity is a
4-alpha-hydroxytetrahydrobiopterin dehydratase activity is a
4-hydroxy-tetrahydrodipicolinate synthase activity is a
4-hydroxybutanoyl-CoA dehydratase activity is a
4-methyloct-2-enoyl-CoA hydratase activity is a
4-oxalmesaconate hydratase activity is a
5-alpha-hydroxysteroid dehydratase activity is a
5-chloro-2-oxopent-4-enoate hydratase activity is a
5-dehydro-4-deoxyglucarate dehydratase activity is a
6-carboxy-5,6,7,8-tetrahydropterin synthase activity is a
acetylene hydratase activity is a
acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate is a
acetylenecarboxylate hydratase activity, producing 3-oxopropanoate is a
aconitate hydratase activity is a
ADP-dependent NAD(P)H-hydrate dehydratase activity is a
aldos-2-ulose dehydratase activity is a
allene oxide synthase activity is a
altronate dehydratase activity is a
arabinonate dehydratase activity is a
arogenate dehydratase activity is a
ATP-dependent NAD(P)H-hydrate dehydratase activity is a
bile-acid 7alpha-dehydratase activity is a
carbonate dehydratase activity is a
carnitine dehydratase activity is a
CDP-glucose 4,6-dehydratase activity is a
colneleate synthase activity is a
colnelenate synthase activity is a
copal-8-ol diphosphate synthase activity is a
crotonyl-CoA hydratase activity is a
cyanamide hydratase activity is a
cyanide hydratase activity is a
cyclohex-1-ene-1-carboxyl-CoA hydratase activity is a
cyclohexa-1,5-dienecarbonyl-CoA hydratase activity is a
cyclohexyl-isocyanide hydratase activity is a
cystathionine beta-synthase activity is a
D(-)-tartrate dehydratase activity is a
D-fuconate dehydratase activity is a
dihydroxy-acid dehydratase activity is a
dimethylmaleate hydratase activity is a
dTDP-glucose 4,6-dehydratase activity is a
E-phenylitaconyl-CoA hydratase activity is a
ectoine synthase activity is a
endosulfan diol hydrolyase (cyclizing) activity is a
enoyl-CoA hydratase activity is a
fumarate hydratase activity is a
galactarate dehydratase activity is a
galactonate dehydratase activity is a
GDP-mannose 4,6-dehydratase activity is a
glucarate dehydratase activity is a
gluconate dehydratase activity is a
glycerol dehydratase activity is a
homoaconitate hydratase activity is a
hydroperoxide dehydratase activity is a
hydroperoxy icosatetraenoate dehydratase activity is a
imidazoleglycerol-phosphate dehydratase activity is a
isohexenylglutaconyl-CoA hydratase activity is a
itaconyl-CoA hydratase activity is a
kievitone hydratase activity is a
L(+)-tartrate dehydratase activity is a
L-altrarate dehydratase activity is a
L-arabinonate dehydratase activity is a
L-erythro-3-methylmalyl-CoA dehydratase activity is a
L-fuconate dehydratase activity is a
L-rhamnonate dehydratase activity is a
L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity is a
lactoyl-CoA dehydratase activity is a
limonene 8-hydratase activity is a
long-chain-enoyl-CoA hydratase activity is a
lupan-3beta,20-diol synthase activity is a
maleate hydratase activity is a
mannonate dehydratase activity is a
menth-2-enone hydratase activity is a
mesaconyl-CoA hydratase activity is a
methylglutaconyl-CoA hydratase activity is a
methylthioribulose 1-phosphate dehydratase activity is a
monocyclic sesterterpenediol synthase activity is a
myo-inosose-2 dehydratase activity is a
naphthyl-2-methylene-succinyl-CoA lyase activity is a
nitrile hydratase activity is a
O-succinylbenzoate synthase activity is a
octopamine dehydratase activity is a
oleate hydratase activity is a
OPC4-trans-2-enoyl-CoA hydratase activity is a
OPC6-trans-2-enoyl-CoA hydratase activity is a
OPC8-trans-2-enoyl-CoA hydratase activity is a
peregrinol diphosphate synthase activity is a
perillyl-CoA hydratase activity is a
phaseollidin hydratase activity is a
phosphogluconate dehydratase activity is a
phosphopyruvate hydratase activity is a
porphobilinogen synthase activity is a
prephenate dehydratase activity is a
propanediol dehydratase activity is a
protoaphin-aglucone dehydratase (cyclizing) activity is a
pterin-4alpha-carbinolamine dehydratase activity is a
pyrazolylalanine synthase activity is a
retinol dehydratase activity is a
scalarane-17alpha-19-diol synthase activity is a
scytalone dehydratase activity is a
selenocystathionine beta-synthase activity is a
synephrine dehydratase activity is a
trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity is a
trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity is a
trans-feruloyl-CoA hydratase activity is a
trans-L-3-hydroxyproline dehydratase activity is a
trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity is a
UDP-glucose 4,6-dehydratase activity is a
urocanate hydratase activity is a
uroporphyrinogen-III synthase activity is a
very-long-chain 3-hydroxyacyl-CoA dehydratase activity is a
xylonate dehydratase activity is a
isochorismate pyruvate lyase activity is a
O-acetylhomoserine sulfhydrylase activity is a
versicolorin B synthase activity is a
carbon-sulfur lyase activity is a
cobalt-precorrin-5A acetaldehyde-lyase activity is a
ferrochelatase activity is a
indoleacetaldoxime dehydratase activity is a
phosphorus-oxygen lyase activity is a
sirohydrochlorin cobaltochelatase activity is a
peptidoglycan muralytic activity is a
transferase activity is a
molecular transducer activity is a
nutrient reservoir activity is a
protein tag is a
small molecule sensor activity is a
structural molecule activity is a
transcription regulator activity is a
transporter activity is a