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Gene ontology
Version 2014-12-22
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Details for oxysterol 7-alpha-hydroxylase activity
Gene ontology ID
GO:0008396
Definition
Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O
Synonyms
1. cytochrome P450 CYP7B1
References
1. PMID 10882791
2. Reactome: R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated"
3. Reactome: R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL"
4. Reactome: R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL"
5. Reactome: R-HSA-5602885 "Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
metabolic process is a
oxidation-reduction process is a
oxidoreductase activity part of
monooxygenase activity is a
steroid hydroxylase activity is a
oxysterol 7-alpha-hydroxylase activity is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
adaptive thermogenesis is a
ATP metabolic process is a
biosynthetic process is a
catabolic process is a
collagen metabolic process is a
demethylation is a
glycosylation is a
hydrogen metabolic process is a
methylation is a
multi-organism metabolic process is a
NAD metabolic process is a
NADH metabolic process is a
NADP metabolic process is a
nitrogen compound metabolic process is a
organic substance metabolic process is a
oxidation-reduction process is a
iodide oxidation is a
oxidative deethylation is a
oxidoreductase activity part of
1,1,1-trichloroethane reductive dehalogenase activity is a
1,1,2-trichloroethene reductive dehalogenase activity is a
1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity is a
1,1-dichloroethane reductive dehalogenase activity is a
1,2-dichloroethene reductive dehalogenase activity is a
2,4-dichloroaniline reductive dehalogenase activity is a
2,4-dichlorophenoxyacetate dehalogenase activity is a
2,5-dichlorohydroquinone reductive dehalogenase activity is a
2-chloro-N-isopropylacetanilide reductive dehalogenase activity is a
2-octaprenylphenol hydroxylase activity is a
2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity is a
3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity is a
3,3',5-tribromobisphenol A reductive dehalogenase activity is a
3,3'-dibromobisphenol A reductive dehalogenase activity is a
3,8-divinyl protochlorophyllide a 8-vinyl reductase activity is a
3-monobromobisphenol A reductive dehalogenase activity is a
alpha-ketoacid dehydrogenase activity is a
arsenate reductase activity is a
chlorate reductase activity is a
chromate reductase activity is a
crotonyl-CoA reductase activity is a
delta1-piperideine-6-carboxylate dehydrogenase activity is a
dihydronicotinamide riboside quinone reductase activity is a
dihydropterin oxidase activity is a
dimethylarsinate reductase activity is a
dioxygenase activity is a
epoxyqueuosine reductase activity is a
fatty acid alpha-hydroxylase activity is a
geranylgeranyl reductase activity is a
glycyl-radical enzyme activating activity is a
heme-copper terminal oxidase activity is a
hydroxymethylbutenyl pyrophosphate reductase activity is a
malolactic enzyme activity is a
monooxygenase activity is a
2-hydroxyisobutyrate 3-monooxygenase activity is a
2-hydroxypyridine 5-monooxygenase activity is a
20-aldehyde-leukotriene B4 20-monooxygenase activity is a
3-hydroxybenzoate 2-monooxygenase activity is a
4-chlorophenoxyacetate monooxygenase activity is a
4-ketotorulene 3-hydroxylase activity is a
4-methoxybenzoate monooxygenase (O-demethylating) activity is a
4-nitrocatechol 4-monooxygenase activity is a
adonirubin 3-hydroxylase activity is a
all-trans retinoic acid 18-hydroxylase activity is a
alpha-pinene monooxygenase activity is a
ammonia monooxygenase activity is a
androst-4-ene-3,17-dione monooxygenase activity is a
arachidonic acid monooxygenase activity is a
beta-carotene 3-hydroxylase activity is a
beta-cryptoxanthin hydroxylase activity is a
canthaxanthin 3-hydroxylase activity is a
carotene beta-ring hydroxylase activity is a
carotene epsilon hydroxylase activity is a
coumarin 7-hydroxylase activity is a
deoxyhypusine monooxygenase activity is a
dibenzothiophene-5,5-dioxide monooxygenase activity is a
echinenone 3-hydroxylase activity is a
estradiol 6-beta-monooxygenase activity is a
eupatolide synthase activity is a
fatty acid in-chain hydroxylase activity is a
ferulate 5-hydroxylase activity is a
germacrene A hydroxylase activity is a
jasmonoyl-isoleucine-12-hydroxylase activity is a
linalool 8-monooxygenase activity is a
linoleic acid epoxygenase activity is a
luciferin monooxygenase activity is a
methyl tertiary butyl ether 3-monooxygenase activity is a
naphthalene hydroxylase activity is a
nitrilotriacetate monooxygenase activity is a
ornithine N5-monooxygenase activity is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) is a
p-coumarate 3-hydroxylase activity is a
phylloquinone monooxygenase (2,3-epoxidizing) activity is a
progesterone 11-alpha-monooxygenase activity is a
progesterone monooxygenase activity is a
retinoic acid 4-hydroxylase activity is a
secalciferol 1-monooxygenase activity is a
steroid 9-alpha-monooxygenase activity is a
steroid hydroxylase activity is a
cholesterol 25-hydroxylase activity is a
cholesterol 26-hydroxylase activity is a
ecdysone 20-monooxygenase activity is a
ecdysteroid 2-hydroxylase activity is a
ecdysteroid 22-hydroxylase activity is a
ecdysteroid 25-hydroxylase activity is a
estrogen 16-alpha-hydroxylase activity is a
estrogen 2-hydroxylase activity is a
oxysterol 7-alpha-hydroxylase activity is a
steroid 17-alpha-monooxygenase activity is a
steroid 21-monooxygenase activity is a
steroid 22-alpha hydroxylase activity is a
steroid 7-alpha-hydroxylase activity is a
sterol 12-alpha-hydroxylase activity is a
testosterone 15-alpha-hydroxylase activity is a
testosterone 16-alpha-hydroxylase activity is a
testosterone 6-beta-hydroxylase activity is a
tert-butanol 2-monooxygenase activity is a
testosterone 16-beta-hydroxylase activity is a
thalianol hydroxylase activity is a
thiophene-2-carbonyl-CoA monooxygenase activity is a
tryptamine 4-monooxygenase activity is a
vitamin D 23-hydroxylase activity is a
vitamin D 24-hydroxylase activity is a
vitamin D 25-hydroxylase activity is a
NADPH-adrenodoxin reductase activity is a
NADPH:sulfur oxidoreductase activity is a
ortho-trichlorophenol reductive dehalogenase activity is a
oxidoreductase activity, acting on a heme group of donors is a
oxidoreductase activity, acting on a sulfur group of donors is a
oxidoreductase activity, acting on CH or CH2 groups is a
oxidoreductase activity, acting on CH-OH group of donors is a
oxidoreductase activity, acting on diphenols and related substances as donors is a
oxidoreductase activity, acting on halogen in donors is a
oxidoreductase activity, acting on hydrogen as donor is a
oxidoreductase activity, acting on iron-sulfur proteins as donors is a
oxidoreductase activity, acting on NAD(P)H is a
oxidoreductase activity, acting on other nitrogenous compounds as donors is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is a
1-hydroxypyrene 6,7-monooxygenase activity is a
1-hydroxypyrene 7,8-monooxygenase activity is a
1-methoxypyrene 6,7-monooxygenase activity is a
11-cis-retinal 3,4-desaturase activity is a
11alpha-30-dihydroxy beta-amyrin dehydrogenase activity is a
2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity is a
2,6-dihydroxybenzothiazole monooxygenase activity is a
2-(methylthio)benzothiazole monooxygenase activity is a
2-hydroxybenzothiazole monooxygenase activity is a
2-octaprenyl-6-methoxyphenol hydroxylase activity is a
3-methylthiopropyl glucosinolate S-oxygenase activity is a
4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity is a
4-chloro-allylglycine synthase activity is a
4-methylthiopropyl glucosinolate S-oxygenase activity is a
5-methylthiopropyl glucosinolate S-oxygenase activity is a
6-deoxocathasterone hydroxylase activity is a
6-deoxotyphasterol C-23 hydroxylase activity is a
6-methylthiopropyl glucosinolate S-oxygenase activity is a
7-methylthiopropyl glucosinolate S-oxygenase activity is a
8-methylthiopropyl glucosinolate S-oxygenase activity is a
9-fluorenone-3,4-dioxygenase activity is a
all-trans retinal 3,4-desaturase activity is a
all-trans retinoic acid 3,4-desaturase activity is a
all-trans retinol 3,4-desaturase activity is a
alpha-pinene dehydrogenase activity is a
amorpha-4,11-diene 12-monooxygenase activity is a
anthracene 9,10-dioxygenase activity is a
benzo(a)pyrene 11,12-epoxidase activity is a
benzothiazole monooxygenase activity is a
betulin dehydrogenase activity is a
bisphenol A hydroxylase B activity is a
carotene 7,8-desaturase activity is a
cathasterone hydroxylase activity is a
delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity is a
delta12-fatty acid dehydrogenase activity is a
di-n-butyltin dioxygenase activity is a
dimethylsilanediol hydroxylase activity is a
endosulfan ether monooxygenase activity is a
endosulfan monooxygenase I activity is a
fatty acid omega-hydroxylase activity is a
fluorene oxygenase activity is a
gamma-glutamyl hercynylcysteine sulfoxide synthase is a
gibberellin A12 16alpha,17 epoxidase activity is a
gibberellin A4 16alpha,17 epoxidase activity is a
gibberellin A9 16alpha,17 epoxidase activity is a
heme oxygenase (decyclizing) activity is a
hercynylselenocysteine synthase is a
hydroxymethylsilanetriol oxidase activity is a
juglone 3-monooxygenase activity is a
kynurenine 7,8-hydroxylase activity is a
labd-13Z-ene-9,15,16-triol synthase activity is a
methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity is a
methylsilanetriol hydroxylase activity is a
mono-butyltin dioxygenase activity is a
monoprenyl isoflavone epoxidase activity is a
myristoyl-CoA 11-(E) desaturase activity is a
myristoyl-CoA 11-(Z) desaturase activity is a
N-nitrodimethylamine hydroxylase activity is a
naphthalene disulfonate 1,2-dioxygenase activity is a
omega-3 fatty acid desaturase activity is a
omega-6 fatty acid desaturase activity is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated is a
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated is a
oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is a
phenylboronic acid monooxygenase activity is a
pinacolone 5-monooxygenase activity is a
plasmanylethanolamine desaturase activity is a
prostaglandin-endoperoxide synthase activity is a
pyrene 1,2-monooxygenase activity is a
pyrene 4,5-monooxygenase activity is a
spheroidene monooxygenase activity is a
sphingolipid delta-4 desaturase activity is a
sphingolipid delta-8 desaturase activity is a
sterol desaturase activity is a
taxadiene 5-alpha-hydroxylase activity is a
thioacetamide S-oxide S-oxygenase activity is a
thioacetamide S-oxygenase activity is a
tri-n-butyltin dioxygenase activity is a
typhasterol C-23 hydroxylase activity is a
uvaol dehydrogenase activity is a
oxidoreductase activity, acting on peroxide as acceptor is a
oxidoreductase activity, acting on phosphorus or arsenic in donors is a
oxidoreductase activity, acting on reduced flavodoxin as donor is a
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is a
oxidoreductase activity, acting on superoxide radicals as acceptor is a
oxidoreductase activity, acting on the aldehyde or oxo group of donors is a
oxidoreductase activity, acting on the CH-CH group of donors is a
oxidoreductase activity, acting on the CH-NH group of donors is a
oxidoreductase activity, acting on the CH-NH2 group of donors is a
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond is a
oxidoreductase activity, oxidizing metal ions is a
oxygen evolving activity is a
perchlorate reductase activity is a
phthalate dioxygenase reductase activity is a
pyrogallol hydroxytransferase activity is a
reduced coenzyme F420 dehydrogenase activity is a
reduced coenzyme F420 oxidase activity is a
reduced coenzyme F420:quinone oxidoreductase activity is a
selenate reductase activity is a
sphingosine hydroxylase activity is a
steroid dehydrogenase activity is a
sulfur oxygenase reductase activity is a
sulfur reductase activity is a
tetrachloroethene reductive dehalogenase activity is a
tetrahydrothiophene 1-oxide reductase activity is a
thyroxine 5'-deiodinase activity is a
thyroxine 5-deiodinase activity is a
trimethylarsine oxidase activity is a
tyramine-beta hydroxylase activity is a
uracil oxygenase activity is a
vinyl chloride reductive dehalogenase activity is a
violaxanthin de-epoxidase activity is a
thioredoxin reduction is a
pigment metabolic process is a
primary metabolic process is a
respiratory burst is a
secondary metabolic process is a
small molecule metabolic process is a
tartrate metabolic process is a
tyrocidine metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a