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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for receptor signaling pathway via STAT
Gene ontology ID
GO:0097696
Definition
An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins
Comment
In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins.
Synonyms
1. kinase activated-STAT cascade
2. kinase-STAT cascade
3. STAT signalling pathway
References
1. GOC: rjd
2. PMID 21534947
3. PMID 24587195
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
biological regulation is a
regulation of biological process is a
negative regulation of natural killer cell differentiation is a
negative regulation of natural killer cell differentiation involved in immune response is a
regulation of cellular process is a
protein kinase C deactivation is a
signal transduction is a
cell surface receptor signaling pathway is a
excitatory chemical synaptic transmission
non-canonical Wnt signaling pathway involved in heart development is a
planar cell polarity pathway involved in pericardium morphogenesis is a
planar cell polarity pathway involved in ventricular septum morphogenesis is a
Wnt signaling pathway involved in forebrain neuroblast division is a
Wnt-activated signaling pathway involved in forebrain neuron fate commitment is a
receptor signaling pathway via STAT is a
vitellogenesis is a
tRNA-containing ribonucleoprotein complex export from nucleus is a
glycyrrhetinate biosynthetic process is a
glycogen metabolic process is a
starch metabolic process is a
leukotriene B4 catabolic process is a
peg and socket contact is a
inner dense plaque of desmosome part of
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
negative regulation of 3'-UTR-mediated mRNA stabilization is a
negative regulation of action potential is a
negative regulation of asexual reproduction is a
negative regulation of biomineralization is a
negative regulation of cellular process is a
negative regulation of natural killer cell differentiation involved in immune response is a
negative regulation of circadian rhythm is a
negative regulation of coflocculation is a
negative regulation of developmental pigmentation is a
negative regulation of developmental process is a
negative regulation of DNA-binding transcription factor activity is a
negative regulation of dosage compensation by inactivation of X chromosome is a
negative regulation of entry of bacterium into host cell is a
negative regulation of establishment of protein localization is a
negative regulation of establishment of RNA localization to telomere is a
negative regulation of fibrinolysis is a
negative regulation of growth is a
negative regulation of GTPase activity is a
negative regulation of guanyl-nucleotide exchange factor activity is a
negative regulation of hemostasis is a
negative regulation of immune system process is a
negative regulation of lipid localization is a
negative regulation of locomotion is a
negative regulation of long-term synaptic potentiation is a
negative regulation of membrane depolarization is a
negative regulation of membrane hyperpolarization is a
negative regulation of metabolic process is a
negative regulation of multi-organism process is a
negative regulation of multicellular organismal process is a
negative regulation of nitrogen utilization is a
negative regulation of nuclear receptor transcription coactivator activity is a
negative regulation of phosphorus utilization is a
negative regulation of posttranscriptional gene silencing is a
negative regulation of proteasome-activating ATPase activity is a
negative regulation of protein localization to cell-cell junction is a
negative regulation of protein localization to presynapse is a
negative regulation of receptor localization to synapse is a
negative regulation of reproductive process is a
negative regulation of response to stimulus is a
negative regulation of defense response is a
negative regulation of cellular defense response is a
negative regulation of CRISPR-cas system is a
negative regulation of defense response to bacterium is a
negative regulation of defense response to insect is a
negative regulation of defense response to oomycetes is a
negative regulation of inflammatory response is a
suppression of host defenses by symbiont is a
effector-mediated defense to host-produced reactive oxygen species is a
suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway is a
suppression by symbiont of host ethylene-mediated defense response is a
suppression by symbiont of host inflammatory response is a
suppression by symbiont of host innate immune response is a
suppression by symbiont of host cytokine secretion is a
suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response is a
suppression by virus of host innate immune response is a
suppression by virus of host IKBKE activity is a
suppression by virus of host ISG15 activity is a
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway is a
viral mRNA cap methylation is a
suppression by symbiont of host resistance gene-dependent defense response is a
negative regulation of detection of glucose is a
negative regulation of response to acetate is a
negative regulation of response to alcohol is a
negative regulation of response to amylopectin is a
negative regulation of response to benzene is a
negative regulation of response to biotic stimulus is a
negative regulation of response to calcium ion is a
negative regulation of response to cycloalkane is a
negative regulation of response to cytokine stimulus is a
negative regulation of response to drug is a
negative regulation of response to external stimulus is a
negative regulation of response to furfural is a
negative regulation of response to gamma radiation is a
negative regulation of response to oxidative stress is a
negative regulation of response to pullulan is a
negative regulation of response to salt stress is a
negative regulation of response to water deprivation is a
negative regulation of response to wounding is a
negative regulation of shade avoidance is a
negative regulation of stress response to copper ion is a
negative regulation of vernalization response is a
negative regulation of short-term synaptic potentiation is a
negative regulation of signaling is a
negative regulation of sulfur utilization is a
negative regulation of telomerase RNA localization to Cajal body is a
negative regulation of transport is a
negative regulation of viral process is a
positive regulation of biological process is a
regulation of action potential is a
regulation of asexual reproduction is a
regulation of biomineralization is a
regulation of carbohydrate utilization is a
regulation of carbon utilization is a
regulation of cellular process is a
cell redox homeostasis is a
modulation by symbiont of host cellular process is a
regulation of actin filament-based process is a
regulation of binding of sperm to zona pellucida is a
regulation of cartilage condensation is a
regulation of cell activation is a
regulation of cell adhesion molecule production is a
regulation of cell aging is a
regulation of cell communication is a
regulation of cell cycle is a
regulation of cell death is a
regulation of cell differentiation is a
regulation of cell division is a
regulation of cell killing is a
regulation of cell population proliferation is a
regulation of cell wall organization or biogenesis is a
regulation of cellular component biogenesis is a
regulation of cellular component movement is a
regulation of cellular component organization is a
regulation of cellular localization is a
regulation of cellular metabolic process is a
regulation of cellular pH reduction is a
regulation of cellular response to alcohol is a
regulation of cellular response to alkaline pH is a
regulation of cellular response to drug is a
regulation of cellular response to gamma radiation is a
regulation of cellular response to growth factor stimulus is a
regulation of cellular response to insulin stimulus is a
regulation of cellular response to macrophage colony-stimulating factor stimulus is a
regulation of cellular response to manganese ion is a
regulation of cellular response to oxidopamine is a
regulation of cellular response to stress is a
regulation of cellular response to testosterone stimulus is a
regulation of cellular response to thapsigargin is a
regulation of cellular response to tunicamycin is a
regulation of cellular response to very-low-density lipoprotein particle stimulus is a
regulation of cellular response to X-ray is a
regulation of chromosome segregation is a
regulation of conjugation is a
regulation of cytolysis is a
regulation of establishment or maintenance of cell polarity is a
regulation of horizontal cell localization is a
regulation of membrane depolarization is a
regulation of microtubule-based process is a
regulation of myelination is a
regulation of peroxidase activity is a
regulation of phenotypic switching is a
regulation of protein folding is a
regulation of response to cell cycle checkpoint signaling is a
regulation of secretion by cell is a
regulation of single-species biofilm formation is a
regulation of stomatal movement is a
regulation of transmembrane transport is a
regulation of transposition is a
regulation of vacuolar transport is a
regulation of vesicle-mediated transport is a
signal transduction is a
apoptotic signaling pathway is a
bile acid signaling pathway is a
calmodulin dependent kinase signaling pathway is a
carbohydrate mediated signaling is a
cell surface receptor signaling pathway is a
anti-Mullerian hormone signaling pathway is a
apolipoprotein A-I-mediated signaling pathway is a
CD40 signaling pathway is a
cell surface receptor signaling pathway involved in cell-cell signaling is a
chemical synaptic transmission, postsynaptic is a
excitatory postsynaptic potential part of
inhibitory postsynaptic potential part of
postsynaptic neurotransmitter receptor activity part of
acetylcholine receptor activity is a
dopamine neurotransmitter receptor activity is a
neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration is a
neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential is a
G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential is a
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential is a
epidermal growth factor receptor signaling pathway involved in lung development is a
mesenchymal smoothened signaling pathway involved in prostate gland development is a
Norrin signaling pathway is a
smoothened signaling pathway involved in lung development is a
Wnt signaling pathway is a
planar cell polarity pathway involved in cardiac muscle cell fate commitment is a
planar cell polarity pathway involved in heart morphogenesis is a
cell surface receptor signaling pathway involved in heart development is a
collagen-activated signaling pathway is a
cytokine-mediated signaling pathway is a
enzyme linked receptor protein signaling pathway is a
Fas signaling pathway is a
glutamate receptor signaling pathway is a
immune response-regulating cell surface receptor signaling pathway is a
integrin-mediated signaling pathway is a
lipopolysaccharide-mediated signaling pathway is a
netrin-activated signaling pathway is a
neuropilin signaling pathway is a
neurotrophin signaling pathway is a
Notch signaling pathway is a
purinergic nucleotide receptor signaling pathway is a
receptor signaling pathway via STAT is a
reelin-mediated signaling pathway is a
Roundabout signaling pathway is a
semaphorin-plexin signaling pathway is a
smoothened signaling pathway is a
Toll signaling pathway is a
urokinase plasminogen activator signaling pathway is a
chloroplast-nucleus signaling pathway is a
dopamine receptor signaling pathway is a
endoplasmic reticulum unfolded protein response is a
ER-nucleus signaling pathway is a
extracellular ATP signaling is a
G protein-coupled receptor signaling pathway is a
hormone-mediated signaling pathway is a
hydrogen peroxide mediated signaling pathway is a
hypoxia-inducible factor-1alpha signaling pathway is a
immune response-regulating signaling pathway is a
intracellular receptor signaling pathway is a
intracellular signal transduction is a
ligand-gated ion channel signaling pathway is a
lipoprotein particle mediated signaling is a
mitochondria-nucleus signaling pathway is a
necroptotic signaling pathway is a
neuronal signal transduction is a
osmosensory signaling pathway is a
pattern recognition receptor signaling pathway is a
peptidoglycan recognition protein signaling pathway is a
phototransduction is a
postsynaptic signal transduction is a
presynaptic signal transduction is a
receptor ligand activity part of
red or far-red light signaling pathway is a
regulation of blood pressure by chemoreceptor signaling pathway is a
regulation of floral organ abscission by signal transduction is a
salicylic acid mediated signaling pathway is a
serotonin receptor signaling pathway is a
signal transduction by conformational transition is a
signal transduction by protein phosphorylation is a
signal transduction in absence of ligand is a
signal transduction involved in cellular response to ammonium ion is a
signal transduction involved in filamentous growth is a
signal transduction involved in regulation of gene expression is a
sphingolipid mediated signaling pathway is a
regulation of circadian rhythm is a
regulation of developmental pigmentation is a
regulation of developmental process is a
regulation of estrogen receptor binding is a
regulation of growth is a
regulation of guanyl-nucleotide exchange factor activity is a
regulation of hemostasis is a
regulation of immune system process is a
regulation of interspecies interactions between organisms is a
regulation of localization is a
regulation of locomotion is a
regulation of membrane hyperpolarization is a
regulation of metabolic process is a
regulation of multi-organism process is a
regulation of multicellular organismal process is a
regulation of nitrogen utilization is a
regulation of phosphorus utilization is a
regulation of plasma lipoprotein particle levels is a
regulation of reproductive process is a
regulation of response to stimulus is a
regulation of signaling is a
regulation of sulfur utilization is a
regulation of biological quality is a
regulation of molecular function is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
actin filament-based process is a
cell activation is a
cell adhesion molecule production is a
cell aggregation is a
cell communication is a
cell cycle is a
cell death is a
cell division is a
cell growth is a
cell killing is a
cell population proliferation is a
cell recognition is a
cell wall organization or biogenesis is a
cell-cell fusion is a
cellular component organization or biogenesis is a
clathrin-dependent endocytosis involved in vitellogenesis part of
cellular detoxification is a
cellular developmental process is a
cellular localization is a
tRNA export from nucleus part of
cellular metabolic process is a
bioluminescence is a
cellular alcohol metabolic process is a
cellular aldehyde metabolic process is a
cellular alkane metabolic process is a
cellular alkene metabolic process is a
cellular alkyne metabolic process is a
cellular aromatic compound metabolic process is a
cellular biosynthetic process is a
cellular carbohydrate metabolic process is a
glycogen debranching enzyme activity part of
cellular catabolic process is a
amyloid-beta clearance by cellular catabolic process is a
antibiotic catabolic process is a
autophagy is a
cellular lipid catabolic process is a
leukotriene-B4 20-monooxygenase activity part of
cellular macromolecule catabolic process is a
cellular nitrogen compound catabolic process is a
cofactor catabolic process is a
drug catabolic process is a
glycerol ether catabolic process is a
heterocycle catabolic process is a
ketone catabolic process is a
organic acid catabolic process is a
6-sulfoquinovose(1-) catabolic process is a
alkanesulfonate catabolic process is a
carboxylic acid catabolic process is a
cellular amino acid catabolic process is a
cellular modified histidine catabolic process is a
dicarboxylic acid catabolic process is a
aldaric acid catabolic process is a
malonate catabolic process is a
oxalate catabolic process is a
prephenate(2-) catabolic process is a
fumonisin catabolic process is a
hyaluronan catabolic process is a
icosanoid catabolic process is a
monocarboxylic acid catabolic process is a
N-acetylmuramic acid catabolic process is a
tricarboxylic acid catabolic process is a
organomercury catabolic process is a
peptide catabolic process is a
peptidyl-diphthamide catabolic process is a
peptidyl-diphthine catabolic process is a
polyphosphate catabolic process is a
receptor catabolic process is a
sulfur compound catabolic process is a
toxin catabolic process is a
vitamin catabolic process is a
xenobiotic catabolic process is a
cellular ketone body metabolic process is a
cellular ketone metabolic process is a
cellular lipid metabolic process is a
cellular macromolecule metabolic process is a
cellular metabolic compound salvage is a
cellular modified amino acid metabolic process is a
cellular nitrogen compound metabolic process is a
cellular organohalogen metabolic process is a
chemosynthesis is a
cofactor metabolic process is a
drug metabolic process is a
generation of precursor metabolites and energy is a
heterocycle metabolic process is a
hydroperoxide metabolic process is a
metabolite repair is a
mucilage metabolic process is a
one-carbon metabolic process is a
organic acid metabolic process is a
organometal metabolic process is a
phosphorus metabolic process is a
photosynthesis is a
prenylation is a
reactive oxygen species metabolic process is a
selenium compound metabolic process is a
sulfur compound metabolic process is a
toxin metabolic process is a
xenobiotic metabolic process is a
cellular pigmentation is a
cellular process involved in reproduction in multicellular organism is a
cellular response to stimulus is a
chromosome segregation is a
cytolysis is a
DNA clamp unloading is a
ensheathment of neurons is a
establishment or maintenance of cell polarity is a
establishment or maintenance of cell type involved in phenotypic switching is a
export from cell is a
intercellular transport is a
intermediate filament-based process is a
light absorption is a
localization of cell is a
membrane docking is a
microtubule organizing center localization is a
microtubule-based process is a
movement of cell or subcellular component is a
multi-organism cellular process is a
phenotypic switching is a
plasmid maintenance is a
process utilizing autophagic mechanism is a
protein folding is a
protein unfolding is a
RNA folding is a
signaling receptor ligand precursor processing is a
stomatal movement is a
syncytium formation is a
transmembrane transport is a
transposition is a
vacuolar transport is a
vesicle-mediated transport is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
cell is a
cellular anatomical entity is a
A band is a727 BRENDA localization in branch, click for list of all
acroblast is a
acrosomal matrix is a724 BRENDA localization in branch, click for list of all
actin body is a
actin cap is a723 BRENDA localization in branch, click for list of all
actin filament branch point is a
actin filament bundle is a
actin fusion focus is a
actin wave is a
actomyosin is a717 BRENDA localization in branch, click for list of all
actomyosin contractile ring, distal actin filament layer is a
actomyosin contractile ring, intermediate layer is a
actomyosin contractile ring, proximal layer is a
alae of collagen and cuticulin-based cuticle extracellular matrix is a
annular furrow extracellular matrix is a
annuli extracellular matrix is a
apical complex is a716 BRENDA localization in branch, click for list of all
apical cytoplasm is a
apical lamina of hyaline layer is a
apical part of cell is a711 BRENDA localization in branch, click for list of all
ascus epiplasm is a
assemblon is a
axon collateral is a709 BRENDA localization in branch, click for list of all
axon hillock is a708 BRENDA localization in branch, click for list of all
axon initial segment is a707 BRENDA localization in branch, click for list of all
axonemal basal plate is a
axonemal central apparatus is a
axonemal outer doublet is a702 BRENDA localization in branch, click for list of all
axoneme is a701 BRENDA localization in branch, click for list of all
bacterial biofilm matrix surface is a
bacterial-type flagellum basal body is a
bacterial-type flagellum filament is a
bacterial-type flagellum hook is a
bacterial-type flagellum hook-filament junction is a
basal labyrinth is a
basal layer of collagen and cuticulin-based cuticle extracellular matrix is a
basal part of cell is a
basolateral cytoplasm is a
bilobe structure is a
blood microparticle is a
Casparian strip is a
cell body is a696 BRENDA localization in branch, click for list of all
cell division site is a693 BRENDA localization in branch, click for list of all
cell junction is a688 BRENDA localization in branch, click for list of all
cell leading edge is a
cell periphery is a651 BRENDA localization in branch, click for list of all
cell plate is a476 BRENDA localization in branch, click for list of all
cell pole is a475 BRENDA localization in branch, click for list of all
cell projection is a
cell septum is a468 BRENDA localization in branch, click for list of all
cell surface is a467 BRENDA localization in branch, click for list of all
cell tip is a
cell trailing edge is a
cellular bud is a
central element is a465 BRENDA localization in branch, click for list of all
central plaque of spindle pole body is a
centriolar satellite is a
centrosomal corona is a
chiasma is a464 BRENDA localization in branch, click for list of all
chromatin is a463 BRENDA localization in branch, click for list of all
chromosomal region is a446 BRENDA localization in branch, click for list of all
cnida is a
compact myelin is a440 BRENDA localization in branch, click for list of all
concave side of sperm head is a
cone matrix sheath is a
contractile ring is a439 BRENDA localization in branch, click for list of all
cortical layer of collagen and cuticulin-based cuticle extracellular matrix is a
costamere is a
cytoophidium is a438 BRENDA localization in branch, click for list of all
cytoplasm is a437 BRENDA localization in branch, click for list of all
deep fiber is a
dense fibrillar component is a250 BRENDA localization in branch, click for list of all
dense nuclear body is a
dinoflagellate antapex is a
dinoflagellate apex is a
dinoflagellate epicone is a
dinoflagellate hypocone is a
DNA replication termination region is a
eisosome is a249 BRENDA localization in branch, click for list of all
endonuclear canal is a248 BRENDA localization in branch, click for list of all
endospore core is a
ensheathing process is a
envelope is a247 BRENDA localization in branch, click for list of all
epicuticle of collagen and cuticulin-based cuticle extracellular matrix is a
extracellular matrix is a246 BRENDA localization in branch, click for list of all
extracellular region is a230 BRENDA localization in branch, click for list of all
extrachromosomal circular DNA is a212 BRENDA localization in branch, click for list of all
extrachromosomal DNA is a211 BRENDA localization in branch, click for list of all
extrinsic component of membrane is a
fibrillar center is a
Flemming body is a
gas vesicle shell is a
germ tube is a209 BRENDA localization in branch, click for list of all
granular component is a208 BRENDA localization in branch, click for list of all
half bridge of spindle pole body is a
host cellular component is a
incipient cellular bud site is a
inclusion body is a193 BRENDA localization in branch, click for list of all
inner membrane pellicle complex is a
inner plaque of spindle pole body is a
intermediate layer of spindle pole body is a
intracellular immature spore is a
intrinsic component of membrane is a
investment cone is a
lateral element is a
lateral loop is a
lateral part of cell is a
leaflet of membrane bilayer is a
manchette is a183 BRENDA localization in branch, click for list of all
median body is a
membrane is a182 BRENDA localization in branch, click for list of all
membrane-enclosed lumen is a
metaphase plate is a119 BRENDA localization in branch, click for list of all
microtubule bundle is a
microtubule end is a118 BRENDA localization in branch, click for list of all
microtubule organizing center is a116 BRENDA localization in branch, click for list of all
midbody is a107 BRENDA localization in branch, click for list of all
myelin sheath is a106 BRENDA localization in branch, click for list of all
neck portion of tanycyte is a
nucleoid is a105 BRENDA localization in branch, click for list of all
nucleus lagging edge is a
nucleus leading edge is a
oral apparatus is a103 BRENDA localization in branch, click for list of all
organelle is a102 BRENDA localization in branch, click for list of all
pellicle is a10 BRENDA localization in branch, click for list of all
periplasmic space is a9 BRENDA localization in branch, click for list of all
photoreceptor inner segment is a8 BRENDA localization in branch, click for list of all
polar tube is a7 BRENDA localization in branch, click for list of all
site of polarized growth is a6 BRENDA localization in branch, click for list of all
somatodendritic compartment is a
sperm head is a5 BRENDA localization in branch, click for list of all
sperm head-tail coupling apparatus is a
sporoplasm is a
subapical part of cell is a
supramolecular complex is a4 BRENDA localization in branch, click for list of all
symplast is a3 BRENDA localization in branch, click for list of all
tail portion of tanycyte is a
thylakoid is a2 BRENDA localization in branch, click for list of all
Yb body is a
intracellular is a81 BRENDA localization in branch, click for list of all
other organism part is a
protein-containing complex is a55 BRENDA localization in branch, click for list of all
virion is a9 BRENDA localization in branch, click for list of all
molecular_function is a