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Ontology explorer

Gene ontology
Version 2014-12-22
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Details for ER-associated misfolded protein catabolic process
Gene ontology ID
GO:0071712
Definition
The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation
Comment
See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
Synonyms
1. endoplasmic reticulum-associated misfolded protein catabolic process
2. endoplasmic reticulum-associated misfolded protein catabolism
3. ER-associated misfolded protein breakdown
4. ER-associated misfolded protein catabolism
5. ER-associated misfolded protein degradation
6. proteasomal protein catabolism of misfolded ER proteins
References
1. GOC: mah
2. GOC: vw
3. PMID 14607247
4. PMID 19520858
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
cellular process is a
vitellogenesis is a
tRNA-containing ribonucleoprotein complex export from nucleus is a
cellular metabolic process is a
cellular catabolic process is a
cellular macromolecule catabolic process is a
cellular protein catabolic process is a
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
proteolysis involved in cellular protein catabolic process part of
proteasomal protein catabolic process is a
ERAD pathway is a
ER-associated misfolded protein catabolic process is a
protein localization to cytosolic proteasome complex involved in ERAD pathway part of
peg and socket contact is a
inner dense plaque of desmosome part of
osmiophilic body is a
synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex is a
senescence-associated vacuole is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
actin filament-based process is a
cell activation is a
cell adhesion molecule production is a
cell aggregation is a
cell communication is a
axon target recognition is a
cell communication by chemical coupling is a
cell communication by electrical coupling is a
cell-cell signaling is a
autocrine signaling is a
c-di-GMP signaling is a
cell-cell signaling by wnt is a
cell-cell signaling involved in amphid sensory organ development is a
cell-cell signaling involved in cell fate commitment is a
cell-cell signaling involved in kidney development is a
cell-cell signaling involved in lung development is a
cell-cell signaling involved in mammary gland development is a
cell-cell signaling involved in placenta development is a
cell-cell signaling via exosome is a
determination of muscle attachment site is a
ectoderm and mesoderm interaction is a
endocrine signaling is a
endodermal-mesodermal cell signaling is a
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification is a
epithelial-mesenchymal cell signaling is a
glial cell-neuron signaling is a
mesenchymal-epithelial cell signaling is a
mesodermal-endodermal cell signaling is a
neuron-glial cell signaling is a
paracrine signaling is a
polyphosphate-mediated signaling is a
quorum sensing is a
signal release part of
stromal-epithelial cell signaling involved in prostate gland development is a
synaptic signaling is a
synaptic signaling by nitric oxide is a
synaptic signaling via neuropeptide is a
trans-synaptic signaling is a
anterograde trans-synaptic signaling is a
retrograde trans-synaptic signaling is a
trans-synaptic signaling by BDNF is a
trans-synaptic signaling by lipid is a
trans-synaptic signaling by soluble gas is a
trans-synaptic signaling by trans-synaptic complex is a
visceral mesoderm-endoderm interaction involved in midgut development is a
cellular response to extracellular stimulus is a
extracellular matrix-cell signaling is a
motogenic signaling initiating cell movement in cerebral cortex is a
motogenic signaling involved in interneuron migration from the subpallium to the cortex is a
motogenic signaling involved in postnatal olfactory bulb interneuron migration is a
pollen-pistil interaction is a
sex determination, somatic-gonadal interaction is a
cell cycle is a
cell death is a
cell division is a
cell growth is a
cell killing is a
cell population proliferation is a
cell recognition is a
cell wall organization or biogenesis is a
cell-cell fusion is a
cellular component organization or biogenesis is a
clathrin-dependent endocytosis involved in vitellogenesis part of
cellular detoxification is a
cellular developmental process is a
cellular localization is a
tRNA export from nucleus part of
cellular metabolic process is a
bioluminescence is a
cellular alcohol metabolic process is a
cellular aldehyde metabolic process is a
cellular alkane metabolic process is a
cellular alkene metabolic process is a
cellular alkyne metabolic process is a
cellular aromatic compound metabolic process is a
cellular biosynthetic process is a
cellular carbohydrate metabolic process is a
cellular catabolic process is a
amyloid-beta clearance by cellular catabolic process is a
antibiotic catabolic process is a
autophagy is a
cellular lipid catabolic process is a
cellular macromolecule catabolic process is a
cellular protein catabolic process is a
histone catabolic process is a
low-density lipoprotein particle receptor catabolic process is a
prosthetic group catabolic process part of
protein catabolic process in the vacuole is a
protein denaturation is a
proteolysis involved in cellular protein catabolic process part of
acrosome matrix dispersal is a
mannoprotein catabolic process is a
modification-dependent protein catabolic process is a
proteasomal protein catabolic process is a
ERAD pathway is a
ER-associated misfolded protein catabolic process is a
protein localization to cytosolic proteasome complex involved in ERAD pathway part of
proteasomal ubiquitin-independent protein catabolic process is a
protein quality control for misfolded or incompletely synthesized proteins is a
proteolysis associated with antigen processing and presentation is a
PSII associated light-harvesting complex II catabolic process is a
rhodopsin catabolic process is a
glycoprotein catabolic process is a
hemoglobin catabolic process is a
modification-dependent macromolecule catabolic process is a
cellular nitrogen compound catabolic process is a
cofactor catabolic process is a
drug catabolic process is a
glycerol ether catabolic process is a
heterocycle catabolic process is a
ketone catabolic process is a
organic acid catabolic process is a
organomercury catabolic process is a
peptide catabolic process is a
peptidyl-diphthamide catabolic process is a
peptidyl-diphthine catabolic process is a
polyphosphate catabolic process is a
receptor catabolic process is a
sulfur compound catabolic process is a
toxin catabolic process is a
vitamin catabolic process is a
xenobiotic catabolic process is a
cellular ketone body metabolic process is a
cellular ketone metabolic process is a
cellular lipid metabolic process is a
cellular lipid biosynthetic process is a
ether lipid metabolic process is a
fatty acid metabolic process is a
fatty acid oxidation is a
lipoate metabolic process is a
lipoxygenase pathway is a
long-chain fatty acid metabolic process is a
medium-chain fatty acid metabolic process is a
methyl-branched fatty acid metabolic process is a
mycolic acid metabolic process is a
oxylipin metabolic process is a
poly(hydroxyalkanoate) biosynthetic process from fatty acid is a
short-chain fatty acid metabolic process is a
2-oxobutyrate metabolic process is a
acetoacetic acid metabolic process is a
butyrate metabolic process is a
propionate metabolic process is a
unsaturated fatty acid metabolic process is a
very long-chain fatty acid metabolic process is a
glycerolipid metabolic process is a
isoprenoid metabolic process is a
lipid modification is a
membrane lipid metabolic process is a
neutral lipid metabolic process is a
oligosaccharide-lipid intermediate biosynthetic process is a
phospholipid metabolic process is a
sulfolipid metabolic process is a
cellular macromolecule metabolic process is a
cellular metabolic compound salvage is a
cellular modified amino acid metabolic process is a
cellular nitrogen compound metabolic process is a
cellular organohalogen metabolic process is a
chemosynthesis is a
cofactor metabolic process is a
drug metabolic process is a
generation of precursor metabolites and energy is a
heterocycle metabolic process is a
hydroperoxide metabolic process is a
metabolite repair is a
mucilage metabolic process is a
one-carbon metabolic process is a
organic acid metabolic process is a
organometal metabolic process is a
phosphorus metabolic process is a
photosynthesis is a
prenylation is a
reactive oxygen species metabolic process is a
selenium compound metabolic process is a
sulfur compound metabolic process is a
toxin metabolic process is a
xenobiotic metabolic process is a
cellular pigmentation is a
cellular process involved in reproduction in multicellular organism is a
cellular response to stimulus is a
chromosome segregation is a
cytolysis is a
DNA clamp unloading is a
ensheathment of neurons is a
establishment or maintenance of cell polarity is a
establishment or maintenance of cell type involved in phenotypic switching is a
export from cell is a
intercellular transport is a
intermediate filament-based process is a
light absorption is a
localization of cell is a
membrane docking is a
microtubule organizing center localization is a
microtubule-based process is a
movement of cell or subcellular component is a
multi-organism cellular process is a
phenotypic switching is a
plasmid maintenance is a
process utilizing autophagic mechanism is a
protein folding is a
protein unfolding is a
RNA folding is a
signaling receptor ligand precursor processing is a
stomatal movement is a
syncytium formation is a
transmembrane transport is a
transposition is a
vacuolar transport is a
vesicle-mediated transport is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
cell is a
cellular anatomical entity is a
A band is a727 BRENDA localization in branch, click for list of all
acroblast is a
acrosomal matrix is a724 BRENDA localization in branch, click for list of all
actin body is a
actin cap is a723 BRENDA localization in branch, click for list of all
actin filament branch point is a
actin filament bundle is a
actin fusion focus is a
actin wave is a
actomyosin is a717 BRENDA localization in branch, click for list of all
actomyosin contractile ring, distal actin filament layer is a
actomyosin contractile ring, intermediate layer is a
actomyosin contractile ring, proximal layer is a
alae of collagen and cuticulin-based cuticle extracellular matrix is a
annular furrow extracellular matrix is a
annuli extracellular matrix is a
apical complex is a716 BRENDA localization in branch, click for list of all
apical cytoplasm is a
apical lamina of hyaline layer is a
apical part of cell is a711 BRENDA localization in branch, click for list of all
ascus epiplasm is a
assemblon is a
axon collateral is a709 BRENDA localization in branch, click for list of all
axon hillock is a708 BRENDA localization in branch, click for list of all
axon initial segment is a707 BRENDA localization in branch, click for list of all
axonemal basal plate is a
axonemal central apparatus is a
axonemal outer doublet is a702 BRENDA localization in branch, click for list of all
axoneme is a701 BRENDA localization in branch, click for list of all
bacterial biofilm matrix surface is a
bacterial-type flagellum basal body is a
bacterial-type flagellum filament is a
bacterial-type flagellum hook is a
bacterial-type flagellum hook-filament junction is a
basal labyrinth is a
basal layer of collagen and cuticulin-based cuticle extracellular matrix is a
basal part of cell is a
basolateral cytoplasm is a
bilobe structure is a
blood microparticle is a
Casparian strip is a
cell body is a696 BRENDA localization in branch, click for list of all
cell division site is a693 BRENDA localization in branch, click for list of all
cell junction is a688 BRENDA localization in branch, click for list of all
cell leading edge is a
cell periphery is a651 BRENDA localization in branch, click for list of all
cell plate is a476 BRENDA localization in branch, click for list of all
cell pole is a475 BRENDA localization in branch, click for list of all
cell projection is a
cell septum is a468 BRENDA localization in branch, click for list of all
cell surface is a467 BRENDA localization in branch, click for list of all
cell tip is a
cell trailing edge is a
cellular bud is a
central element is a465 BRENDA localization in branch, click for list of all
central plaque of spindle pole body is a
centriolar satellite is a
centrosomal corona is a
chiasma is a464 BRENDA localization in branch, click for list of all
chromatin is a463 BRENDA localization in branch, click for list of all
chromosomal region is a446 BRENDA localization in branch, click for list of all
cnida is a
compact myelin is a440 BRENDA localization in branch, click for list of all
concave side of sperm head is a
cone matrix sheath is a
contractile ring is a439 BRENDA localization in branch, click for list of all
cortical layer of collagen and cuticulin-based cuticle extracellular matrix is a
costamere is a
cytoophidium is a438 BRENDA localization in branch, click for list of all
cytoplasm is a437 BRENDA localization in branch, click for list of all
acetolactate synthase complex part of183 BRENDA localization in branch, click for list of all
acetyl-CoA carboxylase complex part of
acidocalcisome part of182 BRENDA localization in branch, click for list of all
ADPG pyrophosphorylase complex part of
alkyl hydroperoxide reductase complex part of181 BRENDA localization in branch, click for list of all
alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) part of
anaerobic ribonucleoside-triphosphate reductase complex part of
anammoxosome part of180 BRENDA localization in branch, click for list of all
anthranilate synthase complex part of179 BRENDA localization in branch, click for list of all
APC-tubulin-IQGAP1 complex part of
Atg1/ULK1 kinase complex part of
Atg12-Atg5-Atg16 complex part of
beta-catenin destruction complex part of
calpain complex part of
carbamoyl-phosphate synthase complex part of
CBM complex part of
Cdc42 GTPase complex part of
citrate lyase complex part of178 BRENDA localization in branch, click for list of all
contractile fiber part of
CRD-mediated mRNA stability complex part of
crystalloid part of169 BRENDA localization in branch, click for list of all
CUGBP1-eIF2 complex part of
Cvt complex part of
cysteine synthase complex part of168 BRENDA localization in branch, click for list of all
cytoplasmic chromosome part of
cytoplasmic cyclin-dependent protein kinase holoenzyme complex part of
cytoplasmic exosome (RNase complex) part of
cytoplasmic microtubule part of162 BRENDA localization in branch, click for list of all
cytoplasmic microtubule bundle part of
cytoplasmic region is a160 BRENDA localization in branch, click for list of all
cytoplasmic ribonucleoprotein granule part of
cytoplasmic U snRNP body part of
cytoplasmic ubiquitin ligase complex part of
cytoplasmic vesicle part of155 BRENDA localization in branch, click for list of all
cytosol part of133 BRENDA localization in branch, click for list of all
dense body part of
DNA gyrase complex part of
DNA topoisomerase IV complex part of
ectoplasm part of124 BRENDA localization in branch, click for list of all
electron transfer flavoprotein complex part of
endoplasmic reticulum-Golgi intermediate compartment part of
eukaryotic translation elongation factor 1 complex part of
eukaryotic translation initiation factor 2 complex part of
eukaryotic translation initiation factor 2B complex part of
eukaryotic translation initiation factor 3 complex part of
eukaryotic translation initiation factor 4F complex part of122 BRENDA localization in branch, click for list of all
FHF complex part of
fusome part of121 BRENDA localization in branch, click for list of all
G-protein beta/gamma-Btk complex part of
G-protein beta/gamma-Raf-1 complex part of
G-protein beta/gamma-subunit complex part of
glutamate-cysteine ligase complex part of
glutamate-tRNA ligase complex part of
glycerol-3-phosphate dehydrogenase complex part of120 BRENDA localization in branch, click for list of all
glycine cleavage complex part of119 BRENDA localization in branch, click for list of all
glycine reductase complex part of118 BRENDA localization in branch, click for list of all
glycine-tRNA ligase complex part of
glycogen granule part of117 BRENDA localization in branch, click for list of all
glycolate oxidase complex part of
goblet cell theca part of
histone mRNA stem-loop binding complex part of
homodimeric decaprenyl diphosphate synthase complex part of
homomeric SMAD protein complex part of
HSP90-CDC37 chaperone complex part of
hydrogenosome part of116 BRENDA localization in branch, click for list of all
hydroxyisourate hydrolase complex part of
imidazoleglycerol-phosphate synthase complex part of
keratohyalin granule part of
membrane coat part of
methane-oxidizing organelle part of
methionyl glutamyl tRNA synthetase complex part of
methylosome part of
microbody part of111 BRENDA localization in branch, click for list of all
mitochondrial cloud part of102 BRENDA localization in branch, click for list of all
mitochondrion part of101 BRENDA localization in branch, click for list of all
mitosome part of84 BRENDA localization in branch, click for list of all
mitotic spindle assembly checkpoint MAD1-MAD2 complex part of
monolayer-surrounded lipid storage body outer lipid monolayer part of
multi-eIF complex part of
Myo2p-Vac17p-Vac8p transport complex part of
N-terminal protein acetyltransferase complex part of
nascent polypeptide-associated complex part of82 BRENDA localization in branch, click for list of all
neurofilament part of81 BRENDA localization in branch, click for list of all
ooplasm is a80 BRENDA localization in branch, click for list of all
ornithine carbamoyltransferase complex part of
PAN complex part of
Par3-APC-KIF3A complex part of
paraferritin complex part of
perinuclear region of cytoplasm part of
periphagosomal region of cytoplasm part of
PHA granule part of79 BRENDA localization in branch, click for list of all
phagophore part of78 BRENDA localization in branch, click for list of all
phagophore assembly site part of
phenylalanine-tRNA ligase complex part of
phosphoenolpyruvate-dependent sugar phosphotransferase complex part of
phosphopantothenoylcysteine decarboxylase complex part of
phosphoribosylaminoimidazole carboxylase complex part of
phosphorylase kinase complex part of77 BRENDA localization in branch, click for list of all
phragmoplast part of76 BRENDA localization in branch, click for list of all
phragmosome part of75 BRENDA localization in branch, click for list of all
pICln-Sm protein complex part of
pirellulosome part of
plasma membrane-derived chromatophore part of
plastid part of73 BRENDA localization in branch, click for list of all
amyloplast is a40 BRENDA localization in branch, click for list of all
apicoplast is a38 BRENDA localization in branch, click for list of all
chloroplast is a37 BRENDA localization in branch, click for list of all
chromoplast is a19 BRENDA localization in branch, click for list of all
cyanelle is a17 BRENDA localization in branch, click for list of all
etioplast is a15 BRENDA localization in branch, click for list of all
etioplast envelope part of
etioplast prolamellar body part of
etioplast stroma part of
prothylakoid part of12 BRENDA localization in branch, click for list of all
gerontoplast is a11 BRENDA localization in branch, click for list of all
leucoplast is a9 BRENDA localization in branch, click for list of all
nucleomorph part of8 BRENDA localization in branch, click for list of all
phenyloplast is a7 BRENDA localization in branch, click for list of all
plastid envelope part of6 BRENDA localization in branch, click for list of all
plastid mRNA editing complex part of
plastid pyruvate dehydrogenase complex part of4 BRENDA localization in branch, click for list of all
plastid stroma part of3 BRENDA localization in branch, click for list of all
plastid thylakoid part of
plastid-encoded plastid RNA polymerase complex part of
proplastid is a1 BRENDA localization in branch, click for list of all
pyrenoid part of
starch grain part of31 BRENDA localization in branch, click for list of all
pole plasm is a30 BRENDA localization in branch, click for list of all
polkadots part of
polyketide synthase complex part of
preprophase band part of28 BRENDA localization in branch, click for list of all
procentriole part of
procentriole replication complex part of
protein body part of27 BRENDA localization in branch, click for list of all
protein farnesyltransferase complex part of
protein phosphatase type 1 complex part of
protein-N(PI)-phosphohistidine-sugar phosphotransferase complex part of
pyruvate dehydrogenase (lipoamide) phosphatase complex part of
pyruvate dehydrogenase complex part of26 BRENDA localization in branch, click for list of all
Rab-protein geranylgeranyltransferase complex part of
RasGAP-Fyn-Lyn-Yes complex part of
RAVE complex part of25 BRENDA localization in branch, click for list of all
ribulose bisphosphate carboxylase complex part of
sarcoplasm is a24 BRENDA localization in branch, click for list of all
sarcosine oxidase complex part of
SCAR complex part of
scintillon part of23 BRENDA localization in branch, click for list of all
Scrib-APC complex part of
Scrib-APC-beta-catenin complex part of
serine-pyruvate aminotransferase complex part of
Sid2-Mob1 complex part of
signal recognition particle part of22 BRENDA localization in branch, click for list of all
Ski complex part of21 BRENDA localization in branch, click for list of all
SMN-Sm protein complex part of
SNARE complex part of20 BRENDA localization in branch, click for list of all
spectrosome part of
sulfate adenylyltransferase complex (ATP) part of
thioglucosidase complex part of
translation initiation complex part of19 BRENDA localization in branch, click for list of all
translation initiation ternary complex part of
translation preinitiation complex part of
translation release factor complex part of
transnitrosylase complex part of
tricarboxylic acid cycle enzyme complex part of
type I site-specific deoxyribonuclease complex part of
type II site-specific deoxyribonuclease complex part of
type III site-specific deoxyribonuclease complex part of
type IV site-specific deoxyribonuclease complex part of
UFD1-NPL4 complex part of
urease complex part of17 BRENDA localization in branch, click for list of all
vacuolar transporter chaperone complex part of
vacuole part of16 BRENDA localization in branch, click for list of all
VCP-NSFL1C complex part of
viral assembly compartment part of
viral assembly intermediate part of
WASH complex part of
yolk part of
deep fiber is a
dense fibrillar component is a250 BRENDA localization in branch, click for list of all
dense nuclear body is a
dinoflagellate antapex is a
dinoflagellate apex is a
dinoflagellate epicone is a
dinoflagellate hypocone is a
DNA replication termination region is a
eisosome is a249 BRENDA localization in branch, click for list of all
endonuclear canal is a248 BRENDA localization in branch, click for list of all
endospore core is a
ensheathing process is a
envelope is a247 BRENDA localization in branch, click for list of all
epicuticle of collagen and cuticulin-based cuticle extracellular matrix is a
extracellular matrix is a246 BRENDA localization in branch, click for list of all
extracellular region is a230 BRENDA localization in branch, click for list of all
extrachromosomal circular DNA is a212 BRENDA localization in branch, click for list of all
extrachromosomal DNA is a211 BRENDA localization in branch, click for list of all
extrinsic component of membrane is a
fibrillar center is a
Flemming body is a
gas vesicle shell is a
germ tube is a209 BRENDA localization in branch, click for list of all
granular component is a208 BRENDA localization in branch, click for list of all
half bridge of spindle pole body is a
host cellular component is a
incipient cellular bud site is a
inclusion body is a193 BRENDA localization in branch, click for list of all
inner membrane pellicle complex is a
inner plaque of spindle pole body is a
intermediate layer of spindle pole body is a
intracellular immature spore is a
intrinsic component of membrane is a
investment cone is a
lateral element is a
lateral loop is a
lateral part of cell is a
leaflet of membrane bilayer is a
manchette is a183 BRENDA localization in branch, click for list of all
median body is a
membrane is a182 BRENDA localization in branch, click for list of all
membrane-enclosed lumen is a
metaphase plate is a119 BRENDA localization in branch, click for list of all
microtubule bundle is a
microtubule end is a118 BRENDA localization in branch, click for list of all
microtubule organizing center is a116 BRENDA localization in branch, click for list of all
midbody is a107 BRENDA localization in branch, click for list of all
myelin sheath is a106 BRENDA localization in branch, click for list of all
neck portion of tanycyte is a
nucleoid is a105 BRENDA localization in branch, click for list of all
nucleus lagging edge is a
nucleus leading edge is a
oral apparatus is a103 BRENDA localization in branch, click for list of all
organelle is a102 BRENDA localization in branch, click for list of all
pellicle is a10 BRENDA localization in branch, click for list of all
periplasmic space is a9 BRENDA localization in branch, click for list of all
photoreceptor inner segment is a8 BRENDA localization in branch, click for list of all
polar tube is a7 BRENDA localization in branch, click for list of all
site of polarized growth is a6 BRENDA localization in branch, click for list of all
somatodendritic compartment is a
sperm head is a5 BRENDA localization in branch, click for list of all
sperm head-tail coupling apparatus is a
sporoplasm is a
subapical part of cell is a
supramolecular complex is a4 BRENDA localization in branch, click for list of all
symplast is a3 BRENDA localization in branch, click for list of all
tail portion of tanycyte is a
thylakoid is a2 BRENDA localization in branch, click for list of all
Yb body is a
intracellular is a81 BRENDA localization in branch, click for list of all
other organism part is a
protein-containing complex is a55 BRENDA localization in branch, click for list of all
virion is a9 BRENDA localization in branch, click for list of all
molecular_function is a