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Gene ontology
Version 2014-12-22
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Details for vascular endothelial growth factor receptor signaling pathway
Gene ontology ID
GO:0048010
Definition
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription
Comment
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
Synonyms
1. VEGF receptor signaling pathway
2. VEGF receptor signalling pathway
3. VEGFR signaling pathway
References
1. GOC: ceb
2. GOC: signaling
3. PR: 000001971
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