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BRENDA support

Ontology explorer

Gene ontology
Version 2014-12-22
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Details for vascular endothelial growth factor signaling pathway
Gene ontology ID
GO:0038084
Definition
A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription
Comment
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'.
Synonyms
1. vascular endothelial growth factor signalling pathway
2. VEGF signaling
3. VEGF-activated signaling pathway
References
1. GOC: signaling
2. PMID 17470632
3. PR: 000003096
4. PR: 000007520
5. PR: 000017284
6. PR: 000017285
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