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Version 2014-12-22
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Details for Bre1-Rad6 ubiquitin ligase complex
Gene ontology ID
GO:1990302
Definition
A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis
Comment
This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay).
References
1. GOC: bhm
2. IntAct: EBI-9102228
3. PMID 19531475
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