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Version 2014-12-22
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Details for ubiquitin activating enzyme complex
Gene ontology ID
GO:0120123
Definition
A protein complex responsible for the catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate
Synonyms
1. E1 complex
2. E1 ubiquitin-activating enzyme
References
1. GOC: lnp
2. PMID 9545234
3. IntAct: EBI-16629455
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