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Gene ontology
Version 2014-12-22
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Details for NLRP3 inflammasome complex
Gene ontology ID
GO:0072559
Definition
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus
References
1. GOC: add
2. GOC: BHF
3. GOC: vp
4. PMID 20303873
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