Ontology explorer

GO:0007186

A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane

1. dimeric G-protein coupled receptor signaling pathway
2. dimeric G-protein coupled receptor signalling pathway
3. G protein coupled receptor protein signaling pathway
4. G protein coupled receptor protein signalling pathway
5. G-protein coupled receptor protein signal transduction
6. G-protein coupled receptor protein signaling pathway
7. G-protein coupled receptor signaling pathway via GPCR dimer
8. G-protein coupled receptor signalling pathway
9. G-protein-coupled receptor protein signalling pathway
10. GPCR signaling pathway
11. GPCR signalling pathway

1. GOC: bf
2. GOC: mah
3. PMID 16902576
4. PMID 24568158
5. Wikipedia: G protein-coupled receptor

is an element of the parent element

is a part of the parent element

is related to the parent element

derives from the parent element

// at least 1 tissue/ enzyme/ localization link in this branch

// tissue/ enzyme/ localization link to BRENDA