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Gene ontology
Version 2014-12-22
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Details for hypoxia-inducible factor-1alpha signaling pathway
Gene ontology ID
GO:0097411
Definition
A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia
Synonyms
1. HIF1alpha pathway
2. hypoxia-inducible factor signaling
3. hypoxia-inducible factor-1alpha signalling pathway
References
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