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Literature summary extracted from

  • Ryle, A.P.
    Pepsinogen B: the zymogen of pepsin B (1965), Biochem. J., 95, 6-16.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.23.2 additional information activation of pepsinogen B to pepsin B rapidly at pH 2, more slowly at pH 4, pepsinogen B contains 1 mol phosphate per mol enzyme, function unclear Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.2 57200
-
 pepsinogen B, gel filtration, 57200 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.23.2 Proteins + H2O Sus scrofa enzyme formed from pepsinogen B, more restricted specificity than pepsin A ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.2 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.2 proteolytic modification
-
 Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.2 pepsinogen B Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.2 gastric mucosa
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.23.2 additional information
-
 with pepsinogen B Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.2 acetyl-Phe-L-diiodotyrosine + H2O
-
 Sus scrofa acetyl-L-phenylalanine + L-diiodotyrosine
-
 ir
3.4.23.2 gelatin + H2O
-
 Sus scrofa ? + ?
-
 ir
3.4.23.2 additional information little if any activity with hemoglobin Sus scrofa ?
-
 ?
3.4.23.2 proteins + H2O gelatin Sus scrofa acetyl-L-phenylalanyl-L-diiodotyrosine + H2O
-
 ir
3.4.23.2 proteins + H2O more restricted specificity than pepsin A Sus scrofa acetyl-L-phenylalanyl-L-diiodotyrosine + H2O
-
 ir
3.4.23.2 proteins + H2O little activity with hemoglobin Sus scrofa acetyl-L-phenylalanyl-L-diiodotyrosine + H2O
-
 ir
3.4.23.2 Proteins + H2O enzyme formed from pepsinogen B, more restricted specificity than pepsin A Sus scrofa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.23.2 ? N-terminal amino acid sequence reported Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.23.2 35.5
-
 assay at Sus scrofa