Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nagase, H.; Barrett, A.J.
    Human plasma kallikrein (1981), Biochem. J., 193, 187-192.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.34 Aprotinin
-
Homo sapiens
3.4.21.34 leupeptin
-
Homo sapiens
3.4.21.34 Pro-Phe-Arg-CH2Cl
-
Homo sapiens
3.4.21.34 Soybean trypsin inhibitor
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.34 22000
-
1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains Homo sapiens
3.4.21.34 28000
-
1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains Homo sapiens
3.4.21.34 36000
-
1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains Homo sapiens
3.4.21.34 86000
-
? * 86000, SDS-PAGE, kallikrein II Homo sapiens
3.4.21.34 88000
-
? * 88000, SDS-PAGE, kallikrein I Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.34 kininogen + H2O Homo sapiens cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Homo sapiens
-
kallikrein I, kallikrein II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.34
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 plasma
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.34 additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 kininogen + H2O cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation Homo sapiens ?
-
?
3.4.21.34 Nalpha-Benzoyl-L-Arg ethyl ester + H2O
-
Homo sapiens Nalpha-Benzoyl-L-Arg + ethanol
-
?

Subunits

EC Number Subunits Comment Organism
3.4.21.34 More ? * 86000, SDS-PAGE, kallikrein II Homo sapiens
3.4.21.34 More ? * 88000, SDS-PAGE, kallikrein I Homo sapiens
3.4.21.34 trimer 1 * 36000, 1 * 28000, 1 * 22000, SDS-PAGE with reduction, 3 chains Homo sapiens