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Literature summary extracted from

  • Mantle, D.; Lauffart, B.; Gibson, A.
    Purification and characterization of leucyl aminopeptidase and pyroglutamyl aminopeptidase from human skeletal muscle (1991), Clin. Chim. Acta, 197, 35-46.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.19.3 dithiothreitol absolute requirement for maintenance of activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.3 amastatin
-
 Homo sapiens
3.4.19.3 Arphamenine B
-
 Homo sapiens
3.4.19.3 chymostatin
-
 Homo sapiens
3.4.19.3 Elastinal
-
 Homo sapiens
3.4.19.3 leupeptin
-
 Homo sapiens
3.4.19.3 NEM
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.19.3 0.08
-
 pyroglutamate-4-methylcoumarin 7-amide
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.19.3 additional information maximal activity in absence of divalent cations Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.19.3 22000
-
 gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.19.3
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.3 skeletal muscle quadriceps muscle Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.19.3 1.093
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.3 luliberin + H2O
-
 Homo sapiens pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
-
 ?
3.4.19.3 neurotensin + H2O
-
 Homo sapiens pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
 ?
3.4.19.3 pyroglutamyl-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens pyroglutamate + 7-amino-4-methylcoumarin
-
 ?
3.4.19.3 thyroliberin + H2O
-
 Homo sapiens pyroglutamate + His-Pro-NH2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.19.3 8.5
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.19.3 7 9.5 50% of maximal activity at pH 7 and at pH 9.5 Homo sapiens