Any feedback?
Literature summary extracted from
- Characterization of a pyroglutamate aminopeptidase from rat serum that degrades thyrotropin-releasing hormone (1978), J. Biol. Chem., 253, 6934-6940.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.19.3 | 1,10-phenanthroline | - |
Rattus norvegicus |  |
| 3.4.19.3 | Cu2+ | CuCl2 | Rattus norvegicus | |
| 3.4.19.3 | EDTA | - |
Rattus norvegicus | |
| 3.4.19.3 | EGTA | - |
Rattus norvegicus | |
| 3.4.19.3 | Hg2+ | HgCl2 | Rattus norvegicus | |
| 3.4.19.3 | Luteinizing hormone-releasing hormone | inhibits hydrolysis of thyrotropin-releasing hormone | Rattus norvegicus | |
| 3.4.19.3 | pyroglutamyl-His methyl ester | inhibits hydrolysis of thyrotropin-releasing hormone | Rattus norvegicus | |
| 3.4.19.3 | pyroglutamyl-L-dopa-Pro-NH2 | inhibits hydrolysis of thyrotropin-releasing hormone | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.19.3 | 0.05 | - |
thyrotrophic hormone releasing hormone | - |
Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.3 | 260000 | - |
gel filtration | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.19.3 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.19.3 | partial | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.19.3 | serum | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.3 | additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.19.3 | thyroliberin + H2O | - |
Rattus norvegicus | pyroglutamate + His-Pro-NH2 | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.19.3 | 6.5 | 8 | hydrolysis of thyrotrophic hormone releasing hormone | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
