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Literature summary extracted from

  • O'Connor, B.; O'Cuinn, G.
    Localization of a narrow-specificity thyroliberin hydrolyzing pyroglutamate aminopeptidase in synaptosomal membranes of guinea-pig brain (1984), Eur. J. Biochem., 144, 271-278.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.3 8-hydroxyquinoline
-
 Cavia porcellus
3.4.19.3 bacitracin weak Cavia porcellus
3.4.19.3 DTT weak Cavia porcellus
3.4.19.3 EDTA
-
 Cavia porcellus
3.4.19.3 iodoacetamide weak Cavia porcellus
3.4.19.3 NEM weak Cavia porcellus
3.4.19.3 PCMB weak Cavia porcellus
3.4.19.3 PMSF
-
 Cavia porcellus
3.4.19.3 puromycin
-
 Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.19.3 membrane synaptosomal Cavia porcellus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.19.3 230000
-
-
 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.3 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.3 brain
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.3 acid-thyroliberin + H2O
-
 Cavia porcellus pyroglutamate + His-Pro
-
 ?
3.4.19.3 pyroglutamyl-His-Gly + H2O
-
 Cavia porcellus pyroglutamate + His-Gly
-
 ?
3.4.19.3 pyroglutamyl-His-Gly-NH2 + H2O
-
 Cavia porcellus pyroglutamate + His-Gly-NH2
-
 ?
3.4.19.3 thyroliberin + H2O removes the N-terminal pyroglutamic acid Cavia porcellus pyroglutamate + His-Pro-NH2
-
 ?