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Literature summary extracted from

  • Simmons, W.H.; Walter, R.
    Carboxamidopeptidase: purification and characterization of a neurohypophyseal hormone inactivating peptidase from toad skin (1980), Biochemistry, 19, 39-48.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.2 4-methylumbelliferyl p-guanidinobenzoate
-
toad
3.4.19.2 antipain
-
toad
3.4.19.2 chymostatin
-
toad
3.4.19.2 concanavalin A
-
toad
3.4.19.2 diisopropyl phosphofluoridate
-
toad
3.4.19.2 Elastatinal
-
toad
3.4.19.2 leupeptin
-
toad
3.4.19.2 Lima bean trypsin inhibitor
-
toad
3.4.19.2 ovoinhibitor
-
toad
3.4.19.2 ovomucoid
-
toad
3.4.19.2 p-Nitrophenyl p-guanidinobenzoate
-
toad
3.4.19.2 PCMB reversed by Cys toad
3.4.19.2 tosyllysine chloromethyl ketone
-
toad
3.4.19.2 tosylphenylalanine chloromethyl ketone
-
toad
3.4.19.2 Trasylol
-
toad

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.19.2 48000
-
2 * 48000, each subunit consists of a heavy chain, 28000 da, and a light chain, 19000 Da joined by a disulfide bond, SDS-PAGE toad
3.4.19.2 100000
-
gel filtration toad

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.19.2 additional information toad enzyme inactivates neurophyseal hormones ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.2 toad
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.19.2
-
toad

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.2 skin
-
toad
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.19.2 acetyl-L-Trp ethyl ester + H2O
-
toad ?
-
?
3.4.19.2 benzoyl-L-Arg ethyl ester + H2O
-
toad ?
-
?
3.4.19.2 additional information enzyme inactivates neurophyseal hormones toad ?
-
?
3.4.19.2 oxytocin + H2O hydrolysis of the Leu8-Gly9-NH2 bond toad glycinamide + ?
-
?
3.4.19.2 [Arg8]-vasopressin + H2O hydrolysis of the Arg8-Gly9-NH2 bond toad ?
-
?

Subunits

EC Number Subunits Comment Organism
3.4.19.2 dimer 2 * 48000, each subunit consists of a heavy chain, 28000 da, and a light chain, 19000 Da joined by a disulfide bond, SDS-PAGE toad

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.19.2 7
-
oxytocin toad
3.4.19.2 7.5 8.5 hydrolysis of 8-arginine-vasopressin or benzoyl-L-Arg ethyl ester toad