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Literature summary extracted from

  • Skladanowski, A.C.; Newby, A.C.
    Partial purification and properties of an AMP-specific 5'-nucleotidase from pigeon heart (1990), Biochem. J., 268, 117-122.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.5 ADP activation of cytosolic enzyme Columba livia
3.1.3.5 ATP activation Columba livia

Application

EC Number Application Comment Organism
3.1.3.5 pharmacology potential site for pharmacological intervention to protect organs against nucleotide depletion Columba livia

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.5 4-nitrophenyl phosphate
-
Columba livia
3.1.3.5 adenosine 5'-(alpha,beta-methylene)diphosphate not inhibitory Columba livia

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.5 4.7
-
5'-AMP
-
Columba livia
3.1.3.5 7.7
-
5'-IMP
-
Columba livia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.5 cytoplasm
-
Columba livia 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.5 Mg2+ activation Columba livia

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.3.5 150000
-
gel filtration Columba livia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.5 5'-IMP + H2O Columba livia the enzyme is principally responsible for dephosphorylation of 5'-IMP but may have some role in adenosine formation ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.5 Columba livia
-
pigeon
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.5 heart
-
Columba livia
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.5 35.8
-
-
Columba livia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.5 5'-AMP + H2O
-
Columba livia adenosine + phosphate
-
?
3.1.3.5 5'-CMP + H2O 61.7% of the activity with 5'-AMP Columba livia cytidine + phosphate
-
?
3.1.3.5 5'-dAMP + H2O i.e. 2'-deoxyadenosine 5'-phosphate Columba livia deoxyadenosine + phosphate
-
?
3.1.3.5 5'-dAMP + H2O 66% of the activity with 5'-AMP Columba livia deoxyadenosine + phosphate
-
?
3.1.3.5 5'-dGMP + H2O i.e. 2'-deoxyguanosine 5'-phosphate Columba livia deoxyguanosine + phosphate
-
?
3.1.3.5 5'-dGMP + H2O 49.9% of the activity with 5'-AMP Columba livia deoxyguanosine + phosphate
-
?
3.1.3.5 5'-dIMP + H2O i.e. 2'-deoxyinosine 5'-phosphate Columba livia deoxyinosine + phosphate
-
?
3.1.3.5 5'-dIMP + H2O 60.9% of the activity with 5'-AMP Columba livia deoxyinosine + phosphate
-
?
3.1.3.5 5'-GMP + H2O 33.5% of the activity with 5'-AMP Columba livia guanosine + phosphate
-
?
3.1.3.5 5'-IMP + H2O 33.1% of the activity with 5'-AMP Columba livia inosine + phosphate
-
?
3.1.3.5 5'-IMP + H2O the enzyme is principally responsible for dephosphorylation of 5'-IMP but may have some role in adenosine formation Columba livia ?
-
?
3.1.3.5 5'-TMP + H2O 15.2% of the activity with 5'-AMP Columba livia thymidine + phosphate
-
?
3.1.3.5 5'-UMP + H2O 49.5% of the activity with 5'-AMP Columba livia uridine + phosphate
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.5 7
-
-
Columba livia