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Literature summary extracted from
- Some properties of purified 3-hydroxy-3-methylglutaryl Coenzyme A reductase phosphatase from rat liver (1982), Arch. Biochem. Biophys., 214, 192-198.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.47 | citrate | - |
Rattus norvegicus |  |
| 3.1.3.47 | CoA | - |
Rattus norvegicus | |
| 3.1.3.47 | EDTA | does not inhibit all reductase phosphatase isoenzymes | Rattus norvegicus | |
| 3.1.3.47 | fluoride | - |
Rattus norvegicus | |
| 3.1.3.47 | hydroxymethylglutaryl-CoA | does not inhibit the reductase phosphatase itself but interacts with the reductase and prevents its activation | Rattus norvegicus | |
| 3.1.3.47 | NADPH | does not inhibit the reductase phosphatase itself but interacts with the reductase and prevents its activation | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.47 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.1.3.47 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.47 | [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.47 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.3.47 | liver | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.47 | brain | - |
Rattus norvegicus | - |
| 3.1.3.47 | fetus | - |
Rattus norvegicus | - |
| 3.1.3.47 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.47 | [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate | - |
? | |
| 3.1.3.47 | [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
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Release 2023.1 (January 2023)
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