Literature summary extracted from

Beatty, S.M.; Hamilton, G.A.
Inhibition of pyruvate dehydrogenase and pyruvate dehydrogenase phosphate phosphatase by glyoxylate (1985), Bioorg. Chem., 13, 14-23.

No PubMed abstract available

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.3.43	cysteine	reverses glyoxylate inhibition	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.3.43	glyoxylate	at concentrations greater than 0.05 mM	Rattus norvegicus

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.1.3.43	Ca2+	-	Rattus norvegicus
3.1.3.43	Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.1.3.43	[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O	Rattus norvegicus	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.43	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.43	adipose	-	Rattus norvegicus	-
3.1.3.43	epididymis	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.43	[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O	-	Rattus norvegicus	[pyruvate dehydrogenase (lipoamide)] + phosphate	-	ir
3.1.3.43	[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O	-	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)