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Literature summary extracted from

  • Cao, S.G.; Hatch, G.M.
    Stimulation of phosphatidylglycerophosphate phosphatase activity by unsaturated fatty acids in rat heart (1994), Lipids, 29, 475-480.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.27 arachidonic acid
-
 Rattus sp.
3.1.3.27 oleic acid 1.9 fold stimulation at 0.5 mM Rattus sp.

General Stability

EC Number General Stability Organism
3.1.3.27 heat labile Rattus sp.
3.1.3.27 PGP-C more sensitive to increasing temperature Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.27 oleic acid higher than 1.5 mM Rattus sp.
3.1.3.27 phosphatidylglycerophosphate more than 100 æM Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.5 0.02
-
 glycerol 3-phosphate 30°C, pH 7.0 Rattus norvegicus
2.7.8.5 0.046
-
 CDP-diacylglycerol pH 7.0, 30°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.5 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.3.27 mitochondrial membrane
-
 Rattus sp. 31966
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.5 CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate Rattus norvegicus involved in synthesis of phosphatidylglycerol ?
-
 ?
3.1.3.27 phosphatidylglycerophosphate + H2O Rattus sp.
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.5 Rattus norvegicus
-
-
-
3.1.3.27 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.5 heart
-
 Rattus norvegicus
-
3.1.3.27 heart
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.5 CDP-1,2-diacyl-sn-glycerol + glycerol 3-phosphate involved in synthesis of phosphatidylglycerol Rattus norvegicus ?
-
 ?
2.7.8.5 CDP-diacylglycerol + sn-glycero-3-phosphate
-
 Rattus norvegicus CMP + phosphatidylglycerophosphate
-
 ?
3.1.3.27 phosphatidylglycerophosphate + H2O
-
 Rattus sp. phosphatidylglycerol + phosphate
-
 ?
3.1.3.27 phosphatidylglycerophosphate + H2O
-
 Rattus sp. ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.7.8.5 55
-
 mitochondrial fraction, 26% loss of activity after 1 min, 70% loss of activity after 5 min Rattus norvegicus