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Literature summary extracted from

  • Hult, K.; Veide, A.; Gatenbeck, S.
    The distribution of the NADPH regenerating mannitol cycle among fungal species (1980), Arch. Microbiol., 128, 253-255.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.67 D-mannitol + NAD+ Fomes pinicola
-
 D-fructose + NADH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Neurospora crassa involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Thermomyces lanuginosus involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Fusarium graminearum involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Ceratocystis multiannulata involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Botrytis cinerea involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Talaromyces islandicus involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Alternaria alternata involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Cladosporium cladosporioides involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ Penicillium glabrum involved in the mannitol cycle, important for NADPH regeneration D-fructose + NADPH + H+
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Cyberlindnera jadinii pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Neurospora crassa pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Aspergillus niger pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Pyricularia oryzae pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Thermomyces lanuginosus pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Fusarium graminearum pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Ceratocystis multiannulata pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Botrytis cinerea pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Talaromyces islandicus pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Penicillus frequentans pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Trichothecium roseum pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Alternaria alternata pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O Cladosporium cladosporioides pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism D-mannitol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.67 Fomes pinicola
-
-
-
1.1.1.138 Alternaria alternata
-
-
-
1.1.1.138 Botrytis cinerea
-
-
-
1.1.1.138 Ceratocystis multiannulata
-
-
-
1.1.1.138 Cladosporium cladosporioides
-
-
-
1.1.1.138 Fusarium graminearum
-
-
-
1.1.1.138 Neurospora crassa
-
-
-
1.1.1.138 Penicillium glabrum
-
-
-
1.1.1.138 Talaromyces islandicus
-
-
-
1.1.1.138 Thermomyces lanuginosus
-
-
-
3.1.3.22 Alternaria alternata
-
-
-
3.1.3.22 Aspergillus niger
-
-
-
3.1.3.22 Botrytis cinerea
-
-
-
3.1.3.22 Ceratocystis multiannulata
-
-
-
3.1.3.22 Cladosporium cladosporioides
-
-
-
3.1.3.22 Cyberlindnera jadinii
-
-
-
3.1.3.22 Fusarium graminearum
-
-
-
3.1.3.22 Neurospora crassa
-
-
-
3.1.3.22 no activity in Agaricus bisporus
-
-
-
3.1.3.22 no activity in Fomes pinicola
-
-
-
3.1.3.22 no activity in Mucor lusitanicus
-
-
-
3.1.3.22 no activity in Phycomyces blakesleeanus
-
-
-
3.1.3.22 no activity in Polyporus versicolor
-
-
-
3.1.3.22 no activity in Rhizopus arrhizus
-
-
-
3.1.3.22 Penicillus frequentans
-
-
-
3.1.3.22 Pyricularia oryzae
-
-
-
3.1.3.22 Talaromyces islandicus
-
-
-
3.1.3.22 Thermomyces lanuginosus
-
-
-
3.1.3.22 Trichothecium roseum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.138 cell culture
-
 Neurospora crassa
-
1.1.1.138 cell culture
-
 Thermomyces lanuginosus
-
1.1.1.138 cell culture
-
 Fusarium graminearum
-
1.1.1.138 cell culture
-
 Ceratocystis multiannulata
-
1.1.1.138 cell culture
-
 Botrytis cinerea
-
1.1.1.138 cell culture
-
 Talaromyces islandicus
-
1.1.1.138 cell culture
-
 Alternaria alternata
-
1.1.1.138 cell culture
-
 Cladosporium cladosporioides
-
1.1.1.138 cell culture
-
 Penicillium glabrum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.22 0.006
-
-
 Cyberlindnera jadinii
3.1.3.22 0.027
-
-
 Aspergillus niger
3.1.3.22 0.045
-
-
 Thermomyces lanuginosus
3.1.3.22 0.048
-
-
 Botrytis cinerea
3.1.3.22 0.06
-
-
 Talaromyces islandicus
3.1.3.22 0.062
-
-
 Fusarium graminearum
3.1.3.22 0.087
-
-
 Pyricularia oryzae
3.1.3.22 0.1
-
-
 Trichothecium roseum
3.1.3.22 0.16
-
-
 Neurospora crassa
3.1.3.22 0.23
-
-
 Ceratocystis multiannulata
3.1.3.22 0.28
-
-
 Penicillus frequentans
3.1.3.22 0.31
-
-
 Cladosporium cladosporioides
3.1.3.22 0.44
-
-
 Alternaria alternata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.67 D-mannitol + NAD+
-
 Fomes pinicola D-fructose + NADH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Neurospora crassa D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Thermomyces lanuginosus D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Fusarium graminearum D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Ceratocystis multiannulata D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Botrytis cinerea D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Talaromyces islandicus D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Alternaria alternata D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Cladosporium cladosporioides D-fructose + NADPH + H+
-
 ?
1.1.1.138 D-mannitol + NADP+ involved in the mannitol cycle, important for NADPH regeneration Penicillium glabrum D-fructose + NADPH + H+
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Cyberlindnera jadinii D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Neurospora crassa D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Aspergillus niger D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Pyricularia oryzae D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Thermomyces lanuginosus D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Fusarium graminearum D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Ceratocystis multiannulata D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Botrytis cinerea D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Talaromyces islandicus D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Penicillus frequentans D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Trichothecium roseum D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Alternaria alternata D-mannitol + phosphate
-
 ?
3.1.3.22 D-mannitol 1-phosphate + H2O pathway for NADPH regeneration and NADH oxidation, regulatory function in carbohydrate metabolism Cladosporium cladosporioides D-mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Cyberlindnera jadinii mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Neurospora crassa mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Aspergillus niger mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Pyricularia oryzae mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Thermomyces lanuginosus mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Fusarium graminearum mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Ceratocystis multiannulata mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Botrytis cinerea mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Talaromyces islandicus mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Penicillus frequentans mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Trichothecium roseum mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Alternaria alternata mannitol + phosphate
-
 ?
3.1.3.22 mannitol 1-phosphate + H2O
-
 Cladosporium cladosporioides mannitol + phosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.67 NAD+
-
 Fomes pinicola
1.1.1.67 NADH
-
 Fomes pinicola
1.1.1.138 NADP+ specific for NADP+ Neurospora crassa
1.1.1.138 NADP+ specific for NADP+ Thermomyces lanuginosus
1.1.1.138 NADP+ specific for NADP+ Fusarium graminearum
1.1.1.138 NADP+ specific for NADP+ Ceratocystis multiannulata
1.1.1.138 NADP+ specific for NADP+ Botrytis cinerea
1.1.1.138 NADP+ specific for NADP+ Talaromyces islandicus
1.1.1.138 NADP+ specific for NADP+ Alternaria alternata
1.1.1.138 NADP+ specific for NADP+ Cladosporium cladosporioides
1.1.1.138 NADP+ specific for NADP+ Penicillium glabrum