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Literature summary extracted from
- Alkaline phosphatase and its function as a protein phosphatase (1987), Adv. Protein Phosphatases, 4, 127-151.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.1 | Ca2+ | 10 mM, glycogen synthase phosphatase activity | Homo sapiens |  |
| 3.1.3.1 | F- | 50 mM KF, 13% inhibition of p-nitrophenyl phosphate hydrolysis, 50% inhibition of dephosphorylation of P-labelled histones | Homo sapiens | |
| 3.1.3.1 | heparin | histone phosphatase activity | Homo sapiens | |
| 3.1.3.1 | levamisole | - |
Bos taurus | |
| 3.1.3.1 | levamisole | 10 mM, 94% inhibition of p-nitrophenyl phosphate hydrolysis, 82% inhibition of dephosphorylation of P-labelled histones | Homo sapiens | |
| 3.1.3.1 | phenylphosphonate | 10 mM, 47% inhibition of p-nitrophenyl phosphate hydrolysis, 80% inhibition of dephosphorylation of P-labelled histones | Homo sapiens | |
| 3.1.3.1 | polylysine | histone phosphatase activity | Homo sapiens | |
| 3.1.3.1 | protamine | histone phosphatase activity | Homo sapiens | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.1 | Mg2+ | - |
Bos taurus | |
| 3.1.3.1 | Mg2+ | stimulates glycogen synthase phosphatase activity | Homo sapiens | |
| 3.1.3.1 | Mn2+ | stimulates glycogen synthase phosphatase activity | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.1 | Bos taurus | - |
calf | - |
| 3.1.3.1 | Escherichia coli | - |
- |
- |
| 3.1.3.1 | Homo sapiens | - |
- |
- |
| 3.1.3.1 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.1 | intestine | - |
Homo sapiens | - |
| 3.1.3.1 | intestine | - |
Sus scrofa | - |
| 3.1.3.1 | intestine | - |
Bos taurus | - |
| 3.1.3.1 | liver | - |
Homo sapiens | - |
| 3.1.3.1 | liver | - |
Sus scrofa | - |
| 3.1.3.1 | liver | - |
Bos taurus | - |
| 3.1.3.1 | placenta | - |
Homo sapiens | - |
| 3.1.3.1 | placenta | - |
Sus scrofa | - |
| 3.1.3.1 | placenta | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.1 | acyl-CoA:cholesterol acyltransferase + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | dentine phosphoprotein + H2O | - |
Bos taurus | ? | - |
? | |
| 3.1.3.1 | glycogen synthase + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | glycogen synthase + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.3.1 | glycogen synthase + H2O | - |
Bos taurus | ? | - |
? | |
| 3.1.3.1 | histone + H2O | 32P-labelled | Homo sapiens | ? | - |
? | |
| 3.1.3.1 | HMG-CoA reductase + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | NADPH-cytochrome reductase + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | p-nitrophenyl phosphate + H2O | - |
Escherichia coli | p-nitrophenol + phosphate | - |
? | |
| 3.1.3.1 | p-nitrophenyl phosphate + H2O | - |
Homo sapiens | p-nitrophenol + phosphate | - |
? | |
| 3.1.3.1 | p-nitrophenyl phosphate + H2O | - |
Bos taurus | p-nitrophenol + phosphate | - |
? | |
| 3.1.3.1 | phospho-Ser histone + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | phospho-Ser histone + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.3.1 | phospho-Ser histone + H2O | - |
Bos taurus | ? | - |
? | |
| 3.1.3.1 | phospho-Ser-casein + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | phospho-Ser-casein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.3.1 | phospho-Ser-casein + H2O | - |
Bos taurus | ? | - |
? | |
| 3.1.3.1 | phospho-Tyr angiotensin + H2O | - |
Bos taurus | angiotensin + phosphate | - |
? | |
| 3.1.3.1 | phospho-Tyr-casein + H2O | - |
Bos taurus | ? | - |
? | |
| 3.1.3.1 | phospho-Tyr-histone + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | phospho-Tyr-histone + H2O | - |
Bos taurus | ? | - |
? | |
| 3.1.3.1 | phosphorylase kinase + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.1.3.1 | phosphorylase kinase + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.3.1 | phosphorylated acetyl-CoA carboxylase + H2O | - |
Homo sapiens | acetyl-CoA carboxylase + phosphate | - |
? | |
| 3.1.3.1 | phosphorylated acetyl-CoA carboxylase + H2O | - |
Bos taurus | acetyl-CoA carboxylase + phosphate | - |
? | |
| 3.1.3.1 | phosvitin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.3.1 | phosvitin + H2O | - |
Bos taurus | ? | - |
? | |
| 3.1.3.1 | protamine + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.1.3.1 | spermidine N'-acetyltransferase + H2O | - |
Bos taurus | ? | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.1 | 56 | - |
- |
Sus scrofa |
| 3.1.3.1 | 56 | - |
- |
Bos taurus |
| 3.1.3.1 | 56 | - |
pH 10.6, 20 min, the isoenzymes from intestine, liver/bone/kidney and from term-placenta are unstable | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.1 | 7.5 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.3.1 | 6 | 9 | pH 6.0: about 30% of maximal activity, pH 9.0: about 15% of maximal activity | Homo sapiens |
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