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Literature summary extracted from
- Effects of nucleotides on a cold labile acetyl-CoA hydrolase from the supernatant fraction of rat liver (1983), Biochemistry, 22, 584-590.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.2.1 | ATP | 2 mM increases the hydrolytic rate | Rattus norvegicus |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.2.1 | 0.00006 | - |
acetyl-CoA | tetrameric enzyme, in presence of 2mM ATP | Rattus norvegicus | |
| 3.1.2.1 | 0.00017 | - |
acetyl-CoA | dimeric enzyme, in presence of 2mM ATP | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.2.1 | additional information | extramitochondrial | Rattus norvegicus | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.1 | 63000 | - |
2 * 63000, SDS-PAGE | Rattus norvegicus |
| 3.1.2.1 | 135000 | - |
gel filtration, dialysis of the enzyme, dimeric form | Rattus norvegicus |
| 3.1.2.1 | 240000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.2.1 | acetyl-CoA + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.2.1 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.2.1 | - |
Rattus norvegicus |
| 3.1.2.1 | 4600fold | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.2.1 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.1 | additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.2.1 | acetyl-CoA + H2O | - |
Rattus norvegicus | CoA + acetate | - |
? | |
| 3.1.2.1 | acetyl-CoA + H2O | - |
Rattus norvegicus | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.2.1 | dimer | 2 * 63000, SDS-PAGE | Rattus norvegicus |
| 3.1.2.1 | tetramer | - |
Rattus norvegicus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.1 | 4 | - |
unstable | Rattus norvegicus |
| 3.1.2.1 | 25 | - |
- |
Rattus norvegicus |
| 3.1.2.1 | 25 | 37 | - |
Rattus norvegicus |
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