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Literature summary extracted from

  • Prass, R.L.; Isohashi, F.; Utter, M.F.
    Purification and characterization of an extramitochondrial acetyl coenzyme A hydrolase from rat liver (1980), J. Biol. Chem., 255, 5215-5223.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.1 ATP 2 mM increases the hydrolytic rate Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.1 ADP complete inhibition by 2 mM Rattus norvegicus
3.1.2.1 ATP 0.5 mM nucleoside phosphate inhibits 49% in Trypanosoma brucei brucei 427 Rattus norvegicus
3.1.2.1 palmitoyl-CoA
-
 Mesocricetus auratus
3.1.2.1 palmitoyl-CoA
-
 Rattus norvegicus
3.1.2.1 Triton X-100
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.1 additional information extramitochondrial Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.1 64000
-
 4 * 64000, SDS-PAGE Rattus norvegicus
3.1.2.1 240000
-
 gel filtration Rattus norvegicus
3.1.2.1 340000
-
 equilibrium centrifugation Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.1 acetyl-CoA + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.1 Bos taurus
-
-
-
3.1.2.1 Cavia porcellus
-
-
-
3.1.2.1 Gallus gallus
-
-
-
3.1.2.1 Mesocricetus auratus
-
-
-
3.1.2.1 Mus musculus
-
-
-
3.1.2.1 Platyrrhini
-
 rhesus
-
3.1.2.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.1
-
 Rattus norvegicus
3.1.2.1 14000fold Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.1 liver
-
 Gallus gallus
-
3.1.2.1 liver
-
 Cavia porcellus
-
3.1.2.1 liver
-
 Mus musculus
-
3.1.2.1 liver
-
 Rattus norvegicus
-
3.1.2.1 liver
-
 Bos taurus
-
3.1.2.1 liver
-
 Mesocricetus auratus
-
3.1.2.1 liver
-
 Platyrrhini
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.2.1 additional information
-
-
 Rattus norvegicus
3.1.2.1 additional information
-
-
 Mesocricetus auratus

Storage Stability

EC Number Storage Stability Organism
3.1.2.1 -90°C Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.1 acetoacetyl-CoA
-
 Rattus norvegicus acetoacetate + CoA
-
 ?
3.1.2.1 acetyl-CoA + H2O
-
 Rattus norvegicus CoA + acetate
-
 ?
3.1.2.1 acetyl-CoA + H2O
-
 Rattus norvegicus ?
-
 ?
3.1.2.1 butyryl-CoA + H2O
-
 Rattus norvegicus butanoate + CoA
-
 ?
3.1.2.1 propionyl-CoA + H2O
-
 Rattus norvegicus CoA + propionate
-
 ?
3.1.2.1 valeryl-CoA
-
 Rattus norvegicus pentanoate + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.1 tetramer 4 * 64000, SDS-PAGE Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.2.1 4
-
-
 Rattus norvegicus
3.1.2.1 25 37
-
 Rattus norvegicus