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Literature summary extracted from
- Acetyl-CoA hydrolase; activity, regulation and physiological significance of the enzyme in brown adipose tissue from hamster (1976), Eur. J. Biochem., 67, 403-410.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.2.1 | ADP | 0.0001 mM activates | Mesocricetus auratus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.2.1 | CoA | - |
Mesocricetus auratus | |
| 3.1.2.1 | CoA | - |
Rattus norvegicus | |
| 3.1.2.1 | NADH | 0.001 mM inhibits | Mesocricetus auratus | |
| 3.1.2.1 | palmitoyl-CoA | 0.0001 mM strongly inhibits | Mesocricetus auratus | |
| 3.1.2.1 | palmitoyl-CoA | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.2.1 | 0.051 | - |
acetyl-CoA | - |
Mesocricetus auratus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.2.1 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
| 3.1.2.1 | mitochondrion | - |
Mesocricetus auratus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.2.1 | CaCl2 | more pronounced stimulation | Mesocricetus auratus | |
| 3.1.2.1 | MgCl2 | slight stimulation | Mesocricetus auratus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.2.1 | Mesocricetus auratus | - |
- |
- |
| 3.1.2.1 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.2.1 | - |
Mesocricetus auratus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.2.1 | brown adipose tissue | - |
Mesocricetus auratus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.2.1 | additional information | - |
- |
Rattus norvegicus |
| 3.1.2.1 | additional information | - |
- |
Mesocricetus auratus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.2.1 | acetyl-CoA + H2O | - |
Mesocricetus auratus | CoA + acetate | - |
? | |
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